THIC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THIC_MOUSE
• UniProt AC: Q8CAY6
• Protein Name: Acetyl-CoA acetyltransferase, cytosolic
• Gene Name: Acat2
• Organism: Mus musculus (Mouse).
• Sequence Length: 397
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MNAGSDPVVIVSAARTAIGSFNGALSTVPVHEMGTTVIKEVLQRAKVAPEEVSEVIFGHVLTAGCGQNPTRQASVGAGIPYSVPAWSCQMICGSGLKAVCLAAQSIAMGDSTIVVAGGMENMSKAPHLTHLRTGVRMGEVPLADSILCDGLTDAFHNYHMGITAENVAKKWQVSREAQDKVAVLSQNRAEHAQKAGHFDKEIVPVLVSSRKGLTEVKIDEFPRHGSNLEAMGKLKPYFLTDGTGTVTPANASGMNDGAAAVVLMKKTEAERRMLKPLARIVSWSQAGVEPSVMGVGPIPAIKQAVAKAGWSLEDVDLFEINEAFAAVSAAIAKELGLNPEKVNIDGGAIALGHPLGASGCRILVTLLHTLERVGGTRGVAALCIGGGMGVAMCVQRG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNAGSDPV -------CCCCCCCE	7.57	-
5	Phosphorylation	---MNAGSDPVVIVS ---CCCCCCCEEEEE	36.01	31437559
12	Phosphorylation	SDPVVIVSAARTAIG CCCEEEEECCHHHHH	12.70	20415495
39	Ubiquitination	EMGTTVIKEVLQRAK HCCHHHHHHHHHHCC	37.12	-
46	Ubiquitination	KEVLQRAKVAPEEVS HHHHHHCCCCHHHHH	40.91	-
65	S-palmitoylation	GHVLTAGCGQNPTRQ HCHHCCCCCCCCCCC	4.74	28526873
65	S-nitrosylation	GHVLTAGCGQNPTRQ HCHHCCCCCCCCCCC	4.74	22178444
65	Glutathionylation	GHVLTAGCGQNPTRQ HCHHCCCCCCCCCCC	4.74	24333276
88	S-palmitoylation	YSVPAWSCQMICGSG CCCCHHHCEECCCCC	1.91	28680068
92	S-palmitoylation	AWSCQMICGSGLKAV HHHCEECCCCCHHHH	2.73	28680068
124	Ubiquitination	GGMENMSKAPHLTHL CCCCCCCCCCCCHHC	55.99	-
170	Ubiquitination	TAENVAKKWQVSREA CHHHHHHHHHCCHHH	32.87	27667366
180	Acetylation	VSREAQDKVAVLSQN CCHHHHHHHHHHCHH	21.73	54348627
180	Ubiquitination	VSREAQDKVAVLSQN CCHHHHHHHHHHCHH	21.73	27667366
180	Malonylation	VSREAQDKVAVLSQN CCHHHHHHHHHHCHH	21.73	26073543
200	Ubiquitination	QKAGHFDKEIVPVLV HHCCCCCHHHHHEEC	48.69	-
200	Acetylation	QKAGHFDKEIVPVLV HHCCCCCHHHHHEEC	48.69	22646873
208	Phosphorylation	EIVPVLVSSRKGLTE HHHHEECCCCCCCCE	21.92	30352176
209	Phosphorylation	IVPVLVSSRKGLTEV HHHEECCCCCCCCEE	30.45	29472430
211	Ubiquitination	PVLVSSRKGLTEVKI HEECCCCCCCCEEEE	61.29	-
211	Malonylation	PVLVSSRKGLTEVKI HEECCCCCCCCEEEE	61.29	26073543
217	Acetylation	RKGLTEVKIDEFPRH CCCCCEEEECCCCCC	37.90	66700323
217	Ubiquitination	RKGLTEVKIDEFPRH CCCCCEEEECCCCCC	37.90	-
233	Acetylation	SNLEAMGKLKPYFLT CCHHHHHCCCCEEEC	40.01	22646881
233	Ubiquitination	SNLEAMGKLKPYFLT CCHHHHHCCCCEEEC	40.01	-
233	Malonylation	SNLEAMGKLKPYFLT CCHHHHHCCCCEEEC	40.01	26073543
235	Ubiquitination	LEAMGKLKPYFLTDG HHHHHCCCCEEECCC	40.95	22790023
235	Acetylation	LEAMGKLKPYFLTDG HHHHHCCCCEEECCC	40.95	22646865
237	Phosphorylation	AMGKLKPYFLTDGTG HHHCCCCEEECCCCC	15.05	36819799
265	Ubiquitination	AAAVVLMKKTEAERR EEEEEEECCHHHHHH	53.00	22790023
275	Acetylation	EAERRMLKPLARIVS HHHHHCHHHHHHHHH	28.74	-
275	Ubiquitination	EAERRMLKPLARIVS HHHHHCHHHHHHHHH	28.74	27667366
284	Phosphorylation	LARIVSWSQAGVEPS HHHHHHHHHCCCCCC	11.57	-
291	Phosphorylation	SQAGVEPSVMGVGPI HHCCCCCCCCCCCCH	15.95	-
302	Ubiquitination	VGPIPAIKQAVAKAG CCCHHHHHHHHHHCC	34.02	27667366
358	Phosphorylation	LGHPLGASGCRILVT HCCCCCHHHHHHHHH	36.31	108495847
360	S-nitrosylation	HPLGASGCRILVTLL CCCCHHHHHHHHHHH	1.96	22178444
360	S-palmitoylation	HPLGASGCRILVTLL CCCCHHHHHHHHHHH	1.96	28526873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THIC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THIC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THIC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of THIC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.