THAP7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THAP7_MOUSE
• UniProt AC: Q8VCZ3
• Protein Name: THAP domain-containing protein 7
• Gene Name: Thap7
• Organism: Mus musculus (Mouse).
• Sequence Length: 309
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors..
• Protein Sequence: MPRHCSAAGCCTRDTRETRNRGISFHRLPKKDNPRRGLWLANCQRLDPSGQGLWDPTSEYIYFCSKHFEENCFELVGISGYHRLKEGAVPTIFESFSKLRRTAKTKGHGYPPGLPDVSRLRRCRKRCSERQGPTTPFSPPPRADIICFPVEEASAPATLPASPAVRLDPGLNSPFSDLLGPLGAQADEAGCSTQPSPEQHPSPLEPQPASPSAYMLRLPPPAGAYIQNEHSYQVGSALLWKRRAEAALDALDKTQRQLQACKRREQRLRLRLTKLQQERAREKRAQADARQTLKDHVQDFAMQLSSSMA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
138	Phosphorylation	QGPTTPFSPPPRADI CCCCCCCCCCCCCCE	37.39	25159016
158	Phosphorylation	EEASAPATLPASPAV HHCCCCCCCCCCCCC	32.01	20469934
162	Phosphorylation	APATLPASPAVRLDP CCCCCCCCCCCCCCC	16.08	20469934
210	Phosphorylation	PLEPQPASPSAYMLR CCCCCCCCCCEEEEE	26.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THAP7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THAP7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THAP7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of THAP7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.