TGM3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TGM3_RAT
• UniProt AC: D4A5U3
• Protein Name: Protein-glutamine gamma-glutamyltransferase E
• Gene Name: Tgm3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 693
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath (By similarity)..
• Protein Sequence: MSALEVQNINWQMPMNRRAHHTDKFSSQDFIVRRGQPWEVILLCNRSLESGDNLNFIVSTGPQPSESARTKAVFSISGRNTSGWSAALKASNGNNLFIAIASPVSAPIGLYTLNVEVSSKGRVSSVKLGTFTVLFNPWQQGDDVFMSNHAERQEYVEEDSGIIYVGSTNRIGMVGWNFGQFEEDILSISLSILDRSLNFRRDPATDVARRNDPKYVCRVLSAMINANDDSGVLSGNWSGNYSGGVDPRTWNGSVEILKNWKKSGFRPVQFGQCWVFAGTLNTVLRCLGVPSRVITNFNSAHDTDRNLSVDVYYDAMGNPLEKGSDSVWNFHVWNEGWFVRTDLGPSYNGWQVLDATPQERSQGVFQCGPASVNAIKDGEVDQNFDMIFIFAEVNADRITWIYNNRDGSQKQNSVDTYSIGKYISTKAVGSNSRMDVTIKYKHPEGSKEERQVQQKAMNKLKPNASFGATSSRGPQGEEKEPSISGKFKVTGVLAVGKEVSLALILKNTTSDRKTVTTNMTAWTIVYNGTLVHEVWKDSATISLDPEEEIQYPVKIAYSQYDRYLKADNMIRITAVCKVPDEAEVVVERDVILDNPTLTLEVLDQAQLRKPVVVQMLFSNPLDEPVKNCVLMVEGSGLLRGSLKIDVPALRPKEKSRVRFEIFPTRIGIKQLLADFSCNKFPAIKAMLVIEVSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	Acetylation	PSESARTKAVFSISG CCCCCCEEEEEEEEC	36.68	22902405
111	Phosphorylation	VSAPIGLYTLNVEVS CCCCEEEEEEEEEEC	12.17	-
112	Phosphorylation	SAPIGLYTLNVEVSS CCCEEEEEEEEEECC	19.52	-
421	Acetylation	VDTYSIGKYISTKAV CCEEEHHHEEEECCC	37.43	22902405
486	Acetylation	KEPSISGKFKVTGVL CCCCCCCCEEEEEEE	34.91	22902405
565	Acetylation	SQYDRYLKADNMIRI HHHHHHHCCCCEEEE	44.77	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TGM3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TGM3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TGM3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TGM3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.