TGM2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TGM2_MOUSE
• UniProt AC: P21981
• Protein Name: Protein-glutamine gamma-glutamyltransferase 2
• Gene Name: Tgm2
• Organism: Mus musculus (Mouse).
• Sequence Length: 686
• Protein Description: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins..
• Protein Sequence: MAEELLLERCDLEIQANGRDHHTADLCQEKLVLRRGQRFRLTLYFEGRGYEASVDSLTFGAVTGPDPSEEAGTKARFSLSDNVEEGSWSASVLDQQDNVLSLQLCTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLYNAWCPADDVYLDSEEERREYVLTQQGFIYQGSVKFIKSVPWNFGQFEDGILDTCLMLLDMNPKFLKNRSRDCSRRSSPIYVGRVVSAMVNCNDDQGVLLGRWDNNYGDGISPMAWIGSVDILRRWKEHGCQQVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGELESNKSEMIWNFHCWVESWMTRPDLQPGYEGWQAIDPTPQEKSEGTYCCGPVSVRAIKEGDLSTKYDAPFVFAEVNADVVDWIRQEDGSVLKSINRSLVVGQKISTKSVGRDDREDITHTYKYPEGSPEEREVFTKANHLNKLAEKEETGVAMRIRVGDSMSMGNDFDVFAHIGNDTSETRECRLLLCARTVSYNGVLGPECGTEDINLTLDPYSENSIPLRILYEKYSGCLTESNLIKVRGLLIEPAANSYLLAERDLYLENPEIKIRVLGEPKQNRKLVAEVSLKNPLSDPLYDCIFTVEGAGLTKEQKSVEVSDPVPAGDLVKARVDLFPTDIGLHKLVVNFQCDKLKSVKGYRNVIIGPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEELLLER ------CHHHHHHHH	20.97	-
10	S-nitrosylation	EELLLERCDLEIQAN HHHHHHHCCEEEECC	5.24	21278135
10	S-nitrosocysteine	EELLLERCDLEIQAN HHHHHHHCCEEEECC	5.24	-
27	S-nitrosocysteine	DHHTADLCQEKLVLR CCCHHHHHHHEEHHH	5.17	-
27	S-nitrosylation	DHHTADLCQEKLVLR CCCHHHHHHHEEHHH	5.17	21278135
30	Malonylation	TADLCQEKLVLRRGQ HHHHHHHEEHHHCCC	20.30	26320211
215	Phosphorylation	SRDCSRRSSPIYVGR CCCCCCCCCCEEECE	39.08	24719451
216	Phosphorylation	RDCSRRSSPIYVGRV CCCCCCCCCEEECEE	17.32	22759359
219	Phosphorylation	SRRSSPIYVGRVVSA CCCCCCEEECEEEEE	10.55	22345495
230	S-nitrosylation	VVSAMVNCNDDQGVL EEEEEEECCCCCCEE	3.93	21278135
230	S-nitrosocysteine	VVSAMVNCNDDQGVL EEEEEEECCCCCCEE	3.93	-
269	S-nitrosocysteine	RRWKEHGCQQVKYGQ HHHHHCCCCCCEECC	2.49	-
269	S-nitrosylation	RRWKEHGCQQVKYGQ HHHHHCCCCCCEECC	2.49	21278135
325	Phosphorylation	NEFGELESNKSEMIW HHCCCCCCCCCCEEE	63.28	-
365	Phosphorylation	DPTPQEKSEGTYCCG CCCCCCCCCCEEEEC	40.27	30352176
368	Phosphorylation	PQEKSEGTYCCGPVS CCCCCCCEEEECCEE	14.88	29472430
369	Phosphorylation	QEKSEGTYCCGPVSV CCCCCCEEEECCEEE	9.15	26032504
414	Acetylation	QEDGSVLKSINRSLV HCCCCHHHHCCCCEE	47.32	23954790
425	Ubiquitination	RSLVVGQKISTKSVG CCEEECEEEECCCCC	32.47	-
425	Malonylation	RSLVVGQKISTKSVG CCEEECEEEECCCCC	32.47	26320211
449	Phosphorylation	TYKYPEGSPEEREVF EEECCCCCHHHHHHH	27.72	26824392
458	Ubiquitination	EEREVFTKANHLNKL HHHHHHHHHHHHHHH	35.41	22790023
468	Acetylation	HLNKLAEKEETGVAM HHHHHHHHHCCCEEE	56.07	23806337
510	Glutathionylation	RECRLLLCARTVSYN HHHHHHEEEEEEEEC	2.13	24333276
553	S-palmitoylation	LYEKYSGCLTESNLI HHHHHCCCCCCCCCE	3.32	28526873
553	S-nitrosylation	LYEKYSGCLTESNLI HHHHHCCCCCCCCCE	3.32	21278135
553	S-nitrosocysteine	LYEKYSGCLTESNLI HHHHHCCCCCCCCCE	3.32	-
589	Ubiquitination	YLENPEIKIRVLGEP ECCCCCCEEEECCCC	23.85	27667366
589	Malonylation	YLENPEIKIRVLGEP ECCCCCCEEEECCCC	23.85	26320211
589	Acetylation	YLENPEIKIRVLGEP ECCCCCCEEEECCCC	23.85	23954790
597	Malonylation	IRVLGEPKQNRKLVA EEECCCCCCCCEEEE	56.77	26320211
601	Malonylation	GEPKQNRKLVAEVSL CCCCCCCEEEEEEEC	55.66	26320211
613	Phosphorylation	VSLKNPLSDPLYDCI EECCCCCCCCHHHEE	38.14	17242355
617	Phosphorylation	NPLSDPLYDCIFTVE CCCCCCHHHEEEEEC	17.73	17242355
619	S-nitrosylation	LSDPLYDCIFTVEGA CCCCHHHEEEEECCC	1.42	21278135
619	S-palmitoylation	LSDPLYDCIFTVEGA CCCCHHHEEEEECCC	1.42	28526873
619	S-nitrosocysteine	LSDPLYDCIFTVEGA CCCCHHHEEEEECCC	1.42	-
622	Phosphorylation	PLYDCIFTVEGAGLT CHHHEEEEECCCCCC	9.57	29472430
648	Malonylation	VPAGDLVKARVDLFP CCHHHHHEEEEEECC	37.46	25418362
648	Acetylation	VPAGDLVKARVDLFP CCHHHHHEEEEEECC	37.46	23864654
648	Ubiquitination	VPAGDLVKARVDLFP CCHHHHHEEEEEECC	37.46	-
669	S-nitrosylation	KLVVNFQCDKLKSVK EHEEEEECCCCCCCC	4.33	21278135
669	S-palmitoylation	KLVVNFQCDKLKSVK EHEEEEECCCCCCCC	4.33	28526873
669	S-nitrosocysteine	KLVVNFQCDKLKSVK EHEEEEECCCCCCCC	4.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
215	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
216	S	Phosphorylation	Kinase	PKACA	P17612	PSP
216	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TGM2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TGM2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TGM2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.