| UniProt ID | TGM1_RAT | |
|---|---|---|
| UniProt AC | P23606 | |
| Protein Name | Protein-glutamine gamma-glutamyltransferase K | |
| Gene Name | Tgm1 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 824 | |
| Subcellular Localization |
Membrane Peripheral membrane protein. |
|
| Protein Description | Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity).. | |
| Protein Sequence | MEGPRSDVGRWGRSPWQPTTPSPEPEPEPEPDRSSRSRRGGGRSFWARCCGCCSCGNRADDDWGPEPSGSRSRGTSSRGGGSRGGDSRGRDSRGGRRPESRGSGVNAAGDGTIREGMLVVNGVDLLCSRSDQNRREHHTDEFEYDELILRRGQPFHIILFLNREYESSDRIALELLIGNNPEVGKGTHVIIPVGKGGSGGWKAQVTKTNGHNLTLRVHTSPNAIIGKFQFTVRTRSEAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDACLYILDRRGMPYGGRGDPVSVSRVVSAMVNSLDDNGVLIGNWTGDYSRGTNPSAWVGSVEILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESIKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAINSNMREDITHIYKHPEGSEAERKAVEKAAAHGSKPNVYATRDSAEDVAMQVEAQDAVMGQDLTVSVVLTNRGSSRRTVKLHLYLCVTYYTGVSGPTFKETKKEVVLAPGASDTVAMPVAYKEYKPHLVDQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPITLTNVVFRLEGSGLQRPKVLNVGDIGGNETVTLRQTFVPVRPGPRQLIASLDSPQLSQVHGVIQVDVAPSSGGRGFSEAVGDSRSGENIPMAFRGGA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Phosphorylation | DVGRWGRSPWQPTTP CCCCCCCCCCCCCCC | 26.93 | 28689409 | |
| 19 | Phosphorylation | GRSPWQPTTPSPEPE CCCCCCCCCCCCCCC | 35.92 | 22673903 | |
| 20 | Phosphorylation | RSPWQPTTPSPEPEP CCCCCCCCCCCCCCC | 28.58 | 22673903 | |
| 22 | Phosphorylation | PWQPTTPSPEPEPEP CCCCCCCCCCCCCCC | 39.54 | 22673903 | |
| 34 | Phosphorylation | PEPEPDRSSRSRRGG CCCCCCCCCCCCCCC | 37.17 | 22673903 | |
| 35 | Phosphorylation | EPEPDRSSRSRRGGG CCCCCCCCCCCCCCC | 34.86 | 23984901 | |
| 68 | Phosphorylation | DDWGPEPSGSRSRGT CCCCCCCCCCCCCCC | 47.98 | 22673903 | |
| 70 | Phosphorylation | WGPEPSGSRSRGTSS CCCCCCCCCCCCCCC | 31.27 | 22673903 | |
| 92 | Phosphorylation | GDSRGRDSRGGRRPE CCCCCCCCCCCCCCC | 31.31 | - | |
| 100 | Phosphorylation | RGGRRPESRGSGVNA CCCCCCCCCCCCCCC | 44.62 | 22673903 | |
| 103 | Phosphorylation | RRPESRGSGVNAAGD CCCCCCCCCCCCCCC | 38.16 | 22673903 | |
| 112 | Phosphorylation | VNAAGDGTIREGMLV CCCCCCCCCCCCEEE | 22.92 | 28689409 | |
| 810 | Phosphorylation | FSEAVGDSRSGENIP HHHHHCCCCCCCCCC | 23.55 | 28689409 | |
| 812 | Phosphorylation | EAVGDSRSGENIPMA HHHCCCCCCCCCCCC | 55.18 | 22673903 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TGM1_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TGM1_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TGM1_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TGM1_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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