TGBR3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TGBR3_MOUSE
• UniProt AC: O88393
• Protein Name: Transforming growth factor beta receptor type 3
• Gene Name: Tgfbr3
• Organism: Mus musculus (Mouse).
• Sequence Length: 850
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Secreted. Secreted, extracellular space, extracellular matrix. Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix..
• Protein Description: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors (By similarity)..
• Protein Sequence: MAVTSHHMVPVFVLMSACLATAGPEPSTRCELSPISASHPVQALMESFTVLSGCASRGTTGLPREVHILNLRSTDQGLGQPQREVTLHLNPIASVHTHHKPVVFLLNSPQPLVWHVKTERLAAGVPRLFLVSEGSVVQFSSGNFSLTAETEERSFPQENEHLLHWAQKEYGAVTSFTELKIARNIYIKVGEDQVFPPTCNIGKNFLSLNYLAEYLQPKAAEGCVLASQPHEKEVHIIELISPNSNPYSTFQVDIIIDIRPAREDPEVVKNLVLILKCKKSVNWVIKSFDVKGNLKVIAPDSIGFGKESERSMTVTKLVRNDYPSTQENLMKWALDNGYSPVTSYTIAPVANRFHLRLENNEEMRDEEVHTIPPELRILLGPDHLPALDSPPFQGEIPNGGFPFPFPDIPRRGWKEGEDRIPRPKEPIIPRVQLLPDHREPEEVQGGVNIALSVKCDNEKMVVAVDKDSFQTNGYSGMELTLLDPSCKAKMNGTHFVLESPLNGCGTRHRRSAPDGVVYYNSIVVQAPSPGDSSGWPDGYEDLESGDNGFPGDTDEGETAPLSRAGVVVFNCSLRQLRSPSGFQDQLDGNATFNMELYNTDLFLVPSPGVFSVAENEHVYVEVSVTKADQDLGFAIQTCFISPYSNPDRMSDYTIIENICPKDDSVKFYSSKRVHFPIPHAEVDKKRFSFVFKSVFNTSLLFLHCELTLCSRNKGSQKLPKCVTPDDACTSLDATMIWTMMQNKKTFTKPLAVVLQVDYKENVPNMKESSPVPPPPQIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETARRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
143	N-linked_Glycosylation	VVQFSSGNFSLTAET EEEECCCCEEEEEEE	25.86	-
207	Phosphorylation	NIGKNFLSLNYLAEY CCCCCCCCHHHHHHH	15.49	25293948
210	Phosphorylation	KNFLSLNYLAEYLQP CCCCCHHHHHHHHCH	16.75	25293948
214	Phosphorylation	SLNYLAEYLQPKAAE CHHHHHHHHCHHHHC	12.67	25293948
491	N-linked_Glycosylation	PSCKAKMNGTHFVLE HHHCCEECCCEEEEE	52.05	-
533	O-linked_Glycosylation	APSPGDSSGWPDGYE CCCCCCCCCCCCCCC	50.01	9659379
544	O-linked_Glycosylation	DGYEDLESGDNGFPG CCCCCCCCCCCCCCC	59.76	9659379
570	N-linked_Glycosylation	RAGVVVFNCSLRQLR CCEEEEEECCCHHCC	11.67	-
589	N-linked_Glycosylation	FQDQLDGNATFNMEL CCCCCCCCCEEEEEE	35.16	-
696	N-linked_Glycosylation	FVFKSVFNTSLLFLH EEHHHHCCHHHHHHH	26.97	-
720	Ubiquitination	KGSQKLPKCVTPDDA CCCCCCCCCCCCCHH	52.34	-
830	Phosphorylation	SPPASENSSAAHSIG CCCCCCCCCCCCCCC	19.80	25338131
849	Phosphorylation	TPCSSSSTA------ CCCCCCCCC------	38.03	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TGBR3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TGBR3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TGBR3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TGBR3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

O-linked Glycosylation

"Murine betaglycan primary structure, expression and glycosaminoglycanattachment sites.";
Ponce-Castaneda M.V., Esparza-Lopez J., Vilchis-Landeros M.M.,Mendoza V., Lopez-Casillas F.;
Biochim. Biophys. Acta 1384:189-196(1998).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION AT SER-533 AND SER-544, ANDMUTAGENESIS OF SER-533 AND SER-544.
PubMed: 9659379