TFE3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TFE3_MOUSE
• UniProt AC: Q64092
• Protein Name: Transcription factor E3
• Gene Name: Tfe3
• Organism: Mus musculus (Mouse).
• Sequence Length: 572
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site..
• Protein Sequence: MSHAAEPARDAVEASAEGPRAVFLLLEERRPAESAQLLSLNSLLPESGIVADIELENILDPDSFYELKSQPLFLRSSLPISLQATPTTPATLSASSSAGGSRTPAMSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVIGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPSSAQPLPAPETAHATGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTAGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPNPGLLSLTTSSVSDSLKPEQLDIEEEGRPSTTFHVSGGPAQNAPPQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEGMVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSMEEES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSHAAEPAR ------CCCCCCHHH	23.10	25338131
87	Phosphorylation	ISLQATPTTPATLSA EEEEECCCCCCEEEC	40.85	28576409
88	Phosphorylation	SLQATPTTPATLSAS EEEECCCCCCEEECC	16.48	28576409
91	Phosphorylation	ATPTTPATLSASSSA ECCCCCCEEECCCCC	23.58	28576409
140 (in isoform 3)	Phosphorylation	-	36.63	29514104
143	Phosphorylation	AAAAPFPSPAPASPA HHHCCCCCCCCCCCC	33.79	29514104
148	Phosphorylation	FPSPAPASPAISVIG CCCCCCCCCCEEEEE	17.50	25367039
152	Phosphorylation	APASPAISVIGVSAG CCCCCCEEEEEEECC	15.13	22705319
187	Methylation	THLENPTRYHLQQAR HHCCCCCHHHHHHHH	20.38	24129315
187	Asymmetric dimethylarginine	THLENPTRYHLQQAR HHCCCCCHHHHHHHH	20.38	-
201	Phosphorylation	RRQQVKQYLSTTLGP HHHHHHHHHHHCCCH	9.26	29514104
203	Phosphorylation	QQVKQYLSTTLGPKL HHHHHHHHHCCCHHH	17.89	29514104
205	Phosphorylation	VKQYLSTTLGPKLAS HHHHHHHCCCHHHHH	26.75	29514104
212	Phosphorylation	TLGPKLASQALTPPP CCCHHHHHCCCCCCC	26.82	25293948
216	Phosphorylation	KLASQALTPPPGPSS HHHHCCCCCCCCCCC	36.44	25293948
222	Phosphorylation	LTPPPGPSSAQPLPA CCCCCCCCCCCCCCC	44.19	25293948
223	Phosphorylation	TPPPGPSSAQPLPAP CCCCCCCCCCCCCCC	33.77	25293948
232	Phosphorylation	QPLPAPETAHATGPT CCCCCCCCCCCCCCC	23.76	25293948
236	Phosphorylation	APETAHATGPTGSAP CCCCCCCCCCCCCCC	33.55	25293948
239	Phosphorylation	TAHATGPTGSAPNSP CCCCCCCCCCCCCCC	45.15	25293948
241	Phosphorylation	HATGPTGSAPNSPMA CCCCCCCCCCCCCEE	42.93	25293948
245 (in isoform 4)	Phosphorylation	-	18.26	29514104
245	Phosphorylation	PTGSAPNSPMALLTI CCCCCCCCCEEEEEC	18.26	25293948
251	Phosphorylation	NSPMALLTIGSSSEK CCCEEEEECCCCCHH	24.92	25293948
254	Phosphorylation	MALLTIGSSSEKEID EEEEECCCCCHHHHH	27.17	25293948
255	Phosphorylation	ALLTIGSSSEKEIDD EEEECCCCCHHHHHH	36.99	25293948
256	Phosphorylation	LLTIGSSSEKEIDDV EEECCCCCHHHHHHH	55.15	25293948
320	Phosphorylation	PAITVSNSCPAELPN CEEEECCCCCCCCCC	17.61	27913603
333	Phosphorylation	PNIKREISETEAKAL CCHHHHCCHHHHHHH	33.44	30635358
335	Phosphorylation	IKREISETEAKALLK HHHHCCHHHHHHHHH	34.16	30635358
370	Phosphorylation	DRIKELGTLIPKSND HHHHHHHHCCCCCCC	33.85	24719451
375	Phosphorylation	LGTLIPKSNDPEMRW HHHCCCCCCCHHHCC	40.90	24719451
391	Phosphorylation	KGTILKASVDYIRKL CHHHHHHHHHHHHHH	17.59	-
414	Phosphorylation	DLESRQRSLEQANRS HHHHHHHHHHHHHHH	28.11	29899451
421	Phosphorylation	SLEQANRSLQLRIQE HHHHHHHHHHHHHHH	21.92	25338131
539	Phosphorylation	GLSGGALSPLRAASD CCCCCCCHHHHHHCC	22.73	-
545	Phosphorylation	LSPLRAASDPLLSSV CHHHHHHCCCCHHCC	38.48	25521595
550	Phosphorylation	AASDPLLSSVSPAVS HHCCCCHHCCCHHHH	36.05	27566939
551	Phosphorylation	ASDPLLSSVSPAVSK HCCCCHHCCCHHHHH	26.95	27087446
553	Phosphorylation	DPLLSSVSPAVSKAS CCCHHCCCHHHHHHH	14.75	27087446
557	Phosphorylation	SSVSPAVSKASSRRS HCCCHHHHHHHHCCC	25.30	27087446
557	O-linked_Glycosylation	SSVSPAVSKASSRRS HCCCHHHHHHHHCCC	25.30	9465747
560	Phosphorylation	SPAVSKASSRRSSFS CHHHHHHHHCCCCCC	28.28	26643407
561	Phosphorylation	PAVSKASSRRSSFSM HHHHHHHHCCCCCCC	36.25	26643407
564	Phosphorylation	SKASSRRSSFSMEEE HHHHHCCCCCCCCCC	34.33	27742792
565	Phosphorylation	KASSRRSSFSMEEES HHHHCCCCCCCCCCC	21.38	25521595
567	Phosphorylation	SSRRSSFSMEEES-- HHCCCCCCCCCCC--	27.51	26824392
572	Phosphorylation	SFSMEEES------- CCCCCCCC-------	49.12	28833060

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
320	S	Phosphorylation	Kinase	MTOR	P42345	PSP
320	S	Phosphorylation	Kinase	MTOR	Q9JLN9	Uniprot
565	S	Phosphorylation	Kinase	AKT1	P31749	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TFE3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TFE3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TFE3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-565, AND MASSSPECTROMETRY.
PubMed: 17242355