dbPTM

TF2B_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TF2B_RAT
UniProt AC	P62916
Protein Name	Transcription initiation factor IIB
Gene Name	Gtf2b
Organism	Rattus norvegicus (Rat).
Sequence Length	316
Subcellular Localization	Nucleus.
Protein Description	General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II..
Protein Sequence	MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPSDFKFDTPVDKLPQL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	DPSRVGDSQNPLLSD CHHHCCCCCCCCCCC	26.40	-
76	Phosphorylation	DSQNPLLSDGDLSTM CCCCCCCCCCCHHHH	47.43	30181290
81	Phosphorylation	LLSDGDLSTMIGKGT CCCCCCHHHHCCCCC	22.22	30181290
92	Phosphorylation	GKGTGAASFDEFGNS CCCCCCCCHHHCCCC	32.47	23984901
238	Acetylation	AATHIARKAVELDLV HHHHHHHHHHHCCCC	48.00	-
259	Phosphorylation	SVAAAAIYMASQASA HHHHHHHHHHHHHHH	5.06	22276854
262	Phosphorylation	AAAIYMASQASAEKR HHHHHHHHHHHHHHH	15.11	22276854

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TF2B_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
238	K	Acetylation		-
Autoacetylated; autoacetylation at Lys-238 stimulates transcription activation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TF2B_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TF2B_RAT

Related Literatures of Post-Translational Modification