TERT_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TERT_ARATH
• UniProt AC: Q9SPU7
• Protein Name: Telomerase reverse transcriptase
• Gene Name: TERT
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1123
• Subcellular Localization: Nucleus . Chromosome, telomere.
• Protein Description: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Required to prevent genome instability induced by breakage-fusion-bridge (BFB) cycles. Can extend completely non-telomeric sequences using RNA template in vitro..
• Protein Sequence: MPRKPRHRVPEILWRLFGNRARNLNDAIVDLIPNRNIQPEQCRCRGQGCLGCSSDKPAFLLRSDDPIHYRKLLHRCFVVLHEQTPPLLDFSPTSWWSQREIVERIIEMMQSGCDCQNVICARYDKYDQSSPILELLTSSSWEFLLKRVGHDVMVYLLQQTSIFLPLLGKKHQQVSGPPLCIKHKRTLSVHENKRKRDDNVQPPTKRQWLSSAVDDCPKDDSATITPIVGEDVDQHREKKTTKRSRIYLKRRRKQRKVNFKKVDCNAPCITPSTNGKVSTGNDEMNLHIGINGSLTDFVKQAKQVKRNKNFKFGLSETYSVIPPNHILKTLRPNCSDSKLLMNHIFGEVNVWSTTPSHGKGNCPSGSICLYHSLLKSLKNLIGKTKSSHLKMLLDKHCPVLLLQEDALKSGTTSQSSRRQKADKLPHGSSSSQTGKPKCPSVEERKLYCTNDQVVSFIWAICRYIVPESLLGTTHQMRVLRKNIAWFVSRRRNEKCTVNQFLHKVKPSDFPFFARKELCCMVNGHELQSESIRSTQQMLCTKWISWLFLEIVKKLVHFNFYATESQGGRLNIYYYRKRSWERLISKEISKALDGYVLVDDAEAESSRKKLSKFRFLPKANGVRMVLDFSSSSRSQSLRDTHAVLKDIQLKEPDVLGSSVFDHDDFYRNLCPYLIHLRSQSGELPPLYFVVADVFKAFDSVDQGKLLHVIQSFLKDEYILNRCRLVCCGKRSNWVNKILVSSDKNSNFSRFTSTVPYNALQSIVVDKGENHRVRKKDLMVWIGNMLKNNMLQLDKSFYVQIAGIPQGHRLSSLLCCFYYGHLERTLIYPFLEEASKDVSSKECSREEELIIPTSYKLLRFIDDYLFVSTSRDQASSFYHRLKHGFKDYNCFMNETKFCINFEDKEEHRCSSNRMFVGDNGVPFVRWTGLLINSRTFEVQVDYTRYLSGHISSTFSVAWQNKPVRNLRQKLCYFLVPKCHPILFDSNINSGEIVRLNIYQIFLLAAMKFHCYVYEVSRFWKLHPQTLFKFITISVRYMFRLINRRVRRINTGSSFRPVLKLYKEEVIWLGLDAYIQVLKKKNSRYRMLLIYLKSALSKHSLSQQLSSELRYATDRSNSSSLWKLNY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
755	Phosphorylation	RFTSTVPYNALQSIV CCCCCCCHHHHCHHE	14.56	19880383
1029	Phosphorylation	QTLFKFITISVRYMF HHHHHHHHHHHHHHH	15.44	19880383
1031	Phosphorylation	LFKFITISVRYMFRL HHHHHHHHHHHHHHH	7.59	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TERT_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TERT_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TERT_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STN1_ARATH	STN1	physical	25329641

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.