dbPTM

TEKT2_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TEKT2_RAT
UniProt AC	Q6AYM2
Protein Name	Tektin-2
Gene Name	Tekt2
Organism	Rattus norvegicus (Rat).
Sequence Length	430
Subcellular Localization	Cytoplasm, cytoskeleton, cilium axoneme . Cytoplasm, cytoskeleton, flagellum axoneme . Cytoplasm, cytoskeleton, microtubule organizing center . Colocalized with CCDC172 at the perinuclear region.
Protein Description	Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules..
Protein Sequence	MATLSLKPSQRYRLSDWLTNSYLLSTNAERQRDASHQIRQEARILRNETNNQTVWDEHDNRTRLAERIDTVNRWKEMLDKCLTDLDAEIDSLTQAKESVEQSLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEEELMKEVEVIEATKKVLQEKISQAFQHLCLLQEIRQQLNSDHRDKMETLEIDRGCLSLNLTAPNLSLKVNPTRVPKDSTTLQEWDDFTRFNKNRADTEMKASIELRETIALAIAQTNNELEAQRVATEFTFRKRLREMESLYSELKWQEKNTLEEIAELQADIRRLEEDLRRKMMNLKLAHTRLESRTYRPNVELCRDQTQYGLIDEVHQLEATISIMKQKLAQTQDALDALFKHLARIQADIACKTNTMLLDTKCMDIRRKLTVPAEKFVPQVDTFTRTTNRTLSPLKTCQLELN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
312	Ubiquitination	RRKMMNLKLAHTRLE HHHHHHHHHHHHHHH	38.33	-
420	Phosphorylation	RTTNRTLSPLKTCQL CCCCCCCCCCCEEEE	27.81	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TEKT2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TEKT2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TEKT2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TEKT2_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TEKT2_RAT

Related Literatures of Post-Translational Modification