dbPTM

TEFM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TEFM_MOUSE
UniProt AC	Q5SSK3
Protein Name	Transcription elongation factor, mitochondrial
Gene Name	Tefm
Organism	Mus musculus (Mouse).
Sequence Length	364
Subcellular Localization	Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.
Protein Description	Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery (By similarity)..
Protein Sequence	MAWRTNLACLIKAGGRRWFPVPEYSSLPPVLNNTCSVRKSTAPEKRVASVAACDTDGKEPGNPLDRLFSLEQQASILQVLNTASDKELEAFRLLRGRKSVNIVEHRKKFGPFQRLENLIDVPLIQYKTAVEVCNSILCPENRRRKKSQEKWLLRKFIKPGVEQERLKAVKSIVSIVFGTRRIAWAHLDRRPTVLDWQQTECWKLTNKTYPTSFYLEEISSVISKIPKADLYILEKSGLSIQNTSLLPILLHFLITEAMLYALLNKTFAEDGQHRVLSINRNAVGKHFDLMIGDTRTSGRELVKQFLSESVLKERPRVFFPQDLLVQYRQKVVKSSYRIEELYDSLLQAVAFYELVFGKDSELKC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAWRTNLACLIK ---CCCCCCEEHEEC	24.71	28576409
53	S-nitrosocysteine	RVASVAACDTDGKEP HEEEEEEECCCCCCC	4.11	-
107	Acetylation	VNIVEHRKKFGPFQR EEEHHHHHHHCHHHH	55.12	22902405
108	Acetylation	NIVEHRKKFGPFQRL EEHHHHHHHCHHHHH	56.35	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TEFM_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TEFM_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TEFM_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TEFM_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TEFM_MOUSE

Related Literatures of Post-Translational Modification