TEFF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TEFF2_HUMAN
• UniProt AC: Q9UIK5
• Protein Name: Tomoregulin-2
• Gene Name: TMEFF2
• Organism: Homo sapiens (Human).
• Sequence Length: 374
• Subcellular Localization: Isoform 1: Membrane ; Single-pass type I membrane protein .; Isoform 2: Membrane ; Single-pass type I membrane protein .; Isoform 3: Secreted.
• Protein Description: May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation..
• Protein Sequence: MVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRSNRIHRQKQNTGHYSSDNTTRASTRLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	N-linked_Glycosylation	CQTPTGWNCSGYDDR CCCCCCCCCCCCCCC	16.06	UniProtKB CARBOHYD
202	Phosphorylation	CASDGKSYDNACQIK ECCCCCCCCCHHHHH	19.39	22817900
204	N-linked_Glycosylation	SDGKSYDNACQIKEA CCCCCCCCHHHHHHH	34.09	19139490
230	N-linked_Glycosylation	SLGRCQDNTTTTTKS EEECCCCCCCCCEEC	17.28	UniProtKB CARBOHYD
231	Phosphorylation	LGRCQDNTTTTTKSE EECCCCCCCCCEECC	33.53	-
309	Phosphorylation	KKDYSVLYVVPGPVR CCCEEEEEECCCCCH	9.39	-
319	Phosphorylation	PGPVRFQYVLIAAVI CCCCHHHHHHHHHHH	8.43	-
358	Phosphorylation	IHRQKQNTGHYSSDN CCCCCCCCCCCCCCC	23.88	-
361	Phosphorylation	QKQNTGHYSSDNTTR CCCCCCCCCCCCCCC	15.94	-
362	Phosphorylation	KQNTGHYSSDNTTRA CCCCCCCCCCCCCCC	26.07	-
363	Phosphorylation	QNTGHYSSDNTTRAS CCCCCCCCCCCCCCE	27.93	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TEFF2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TEFF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TEFF2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TEFF2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.