TECR_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TECR_RAT
• UniProt AC: Q64232
• Protein Name: Very-long-chain enoyl-CoA reductase {ECO:0000305}
• Gene Name: Tecr
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 308
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators..
• Protein Sequence: MKHYEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MKHYEVEIR ------CCCEEEEEE	55.69	22902405
22	Acetylation	EKLCFLDKVEPQATI HHEECCCCCCCCCCH	51.12	22902405
38	Acetylation	EIKTLFTKTHPQWYP HHHHHHHCCCCCCCC	37.19	22902405
58	Phosphorylation	RLDPKGKSLKDEDVL CCCCCCCCCCCHHHH	49.69	29779826
60	Acetylation	DPKGKSLKDEDVLQK CCCCCCCCCHHHHHH	67.19	22902405
60	Succinylation	DPKGKSLKDEDVLQK CCCCCCCCCHHHHHH	67.19	26843850
164	N-linked_Glycosylation	PLRNIFKNCTYYWGF CHHHHHCCCCHHHHH	16.77	-
247	N-linked_Glycosylation	FLLVSCPNYTYEVGS EEEECCCCCCCCCCH	46.21	-
291	Acetylation	GKHRSYLKEFRDYPP CCCHHHHHHHCCCCC	46.72	22902405
291	Ubiquitination	GKHRSYLKEFRDYPP CCCHHHHHHHCCCCC	46.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TECR_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TECR_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TECR_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TECR_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.