TEBP_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TEBP_RAT
• UniProt AC: P83868
• Protein Name: Prostaglandin E synthase 3
• Gene Name: Ptges3 {ECO:0000250|UniProtKB:Q15185}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 160
• Subcellular Localization: Cytoplasm .
• Protein Description: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). [PubMed: 10922363 Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (By similarity]
• Protein Sequence: MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMDHMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Acetylation	-MQPASAKWYDRRDY -CCCCCCCCCCCCCE	43.73	22902405
33	Acetylation	DVNVNFEKSKLTFSC CCEEEEEECCEEEEE	49.07	22902405
33	Ubiquitination	DVNVNFEKSKLTFSC CCEEEEEECCEEEEE	49.07	-
39	Phosphorylation	EKSKLTFSCLGGSDN EECCEEEEECCCCCC	11.82	28432305
40	S-nitrosocysteine	KSKLTFSCLGGSDNF ECCEEEEECCCCCCC	3.41	-
40	S-nitrosylation	KSKLTFSCLGGSDNF ECCEEEEECCCCCCC	3.41	21278135
44	Phosphorylation	TFSCLGGSDNFKHLN EEEECCCCCCCCCCC	27.81	27097102
48	Ubiquitination	LGGSDNFKHLNEIDL CCCCCCCCCCCCEEE	54.13	-
58	S-nitrosocysteine	NEIDLFHCIDPNDSK CCEEEEEEECCCCCC	2.71	-
58	S-nitrosylation	NEIDLFHCIDPNDSK CCEEEEEEECCCCCC	2.71	21278135
64	Phosphorylation	HCIDPNDSKHKRTDR EEECCCCCCCCCCCC	43.21	23984901
69	Phosphorylation	NDSKHKRTDRSILCC CCCCCCCCCCEEEEE	40.34	23984901
72	Phosphorylation	KHKRTDRSILCCLRK CCCCCCCEEEEEEEC	23.79	23984901
79	Succinylation	SILCCLRKGESGQSW EEEEEEECCCCCCCC	54.82	26843850
82	Phosphorylation	CCLRKGESGQSWPRL EEEECCCCCCCCCCC	51.29	23984901
85	Phosphorylation	RKGESGQSWPRLTKE ECCCCCCCCCCCCHH	42.44	27097102
100	Phosphorylation	RAKLNWLSVDFNNWK HHHCCEEEECCCCCC	15.97	27097102
113	Phosphorylation	WKDWEDDSDEDMSNF CCCCCCCCCHHCCCH	56.04	19700791
118	Phosphorylation	DDSDEDMSNFDRFSE CCCCHHCCCHHHHHH	46.82	23298284
124	Phosphorylation	MSNFDRFSEMMDHMG CCCHHHHHHHHHHCC	26.02	28689409
148	Phosphorylation	VDGADDDSQDSDDEK CCCCCCCCCCCCCCC	42.77	29779826
151	Phosphorylation	ADDDSQDSDDEKMPD CCCCCCCCCCCCCCC	39.05	29779826

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TEBP_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TEBP_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TEBP_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TEBP_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.