TDX_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TDX_ARATH
• UniProt AC: Q8VWG7
• Protein Name: TPR repeat-containing thioredoxin TDX
• Gene Name: TDX
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 380
• Protein Description: Thiol-disulfide oxidoreductase that possesses insulin disulfide bonds reducing activity, disulfide reductase, foldase chaperone and holdase chaperone activities. Heat shock causes oligomerization and formation of high molecular weiht (HMW) complexes with concomitant functional switching from a disulfide reductase and foldase chaperone to a holdase chaperone. May interact with HSP70 proteins through the TPR repeats..
• Protein Sequence: MVDAIQVAELRRFVEQLKLNPSILHDPSLVFFKEYLRSLGAQVPKIEKTERDYEDKAETKPSFSPKHDDDDDDIMESDVELDNSDVVEPDNEPPQPMGDPTAEVTDENRDDAQSEKSKAMEAISDGRFDEAIEHLTKAVMLNPTSAILYATRASVFLKVKKPNAAIRDANVALQFNSDSAKGYKSRGMAKAMLGQWEEAAADLHVASKLDYDEEIGTMLKKVEPNAKRIEEHRRKYQRLRKEKELQRAERERRKQQEAQEREAQAALNDGEVISIHSTSELEAKTKAAKKASRLLILYFTATWCGPCRYMSPLYSNLATQHSRVVFLKVDIDKANDVAASWNISSVPTFCFIRDGKEVDKVVGADKGSLEQKIAQHSSSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MVDAIQVAE ------CCCHHHHHH	7.37	22223895
52 (in isoform 2)	Phosphorylation	-	44.96	19880383
53	Phosphorylation	IEKTERDYEDKAETK CCCCCCCCHHHCCCC	32.04	23776212
59	Phosphorylation	DYEDKAETKPSFSPK CCHHHCCCCCCCCCC	53.79	23776212
62	Phosphorylation	DKAETKPSFSPKHDD HHCCCCCCCCCCCCC	39.65	23776212
64	Phosphorylation	AETKPSFSPKHDDDD CCCCCCCCCCCCCCC	37.06	23776212
77	Phosphorylation	DDDDIMESDVELDNS CCCCHHHCCEECCCC	29.58	27531888
322	Phosphorylation	SNLATQHSRVVFLKV HCCCCCCCEEEEEEE	19.56	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TDX_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TDX_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TDX_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of TDX_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.