| UniProt ID | TDRD5_HUMAN | |
|---|---|---|
| UniProt AC | Q8NAT2 | |
| Protein Name | Tudor domain-containing protein 5 | |
| Gene Name | TDRD5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 981 | |
| Subcellular Localization | Cytoplasm. Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis.. | |
| Protein Description | Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity).. | |
| Protein Sequence | MSEQERIQECLRKEIRSLLISTKDGLSPQELEKEYLLMVGNHLPLRILGYRSTMELVLDMPDVVRVCPGAGGTVILKAIPDESTKGIASLVAKQRSSHKLRNSMHKGRPSIYSGPRSHRRVPYRGRVAPILPAVVKSELKDLLALSPVLLSDFEKAFAKRFGRSFQYMQYGFLSMFEVLNAASDVISVEQTRAGSLLMLKKSVTEEKPRGCPAGKIFTQPFRMKQGSYSTGFPVAKPCFSQPTSNMEPPKQIMSMEKTSKLNVVETSRLNHTEKLNQLENTFKSVIAQIGPGGTISSELKHKIKFVVSKFPEGLFISKLLGEYEVIFKEQLSPKKLGFLNVTELVGALSDILHVEFRKGHQDLLVFDADKKPLPPVQSDKKIEAKACVSSPPRNSLSTAAVKETVWNCPSKKQKEPQQKICKKPNLVVKPLQLQVETNKSELNLAMANHDIPPDAVPNKKLCRLPPLDTSSLIGVFVEYIISPSQFYIRIYSRDSSELLEDMMIEMRRCYSNQLVSDRYVMPECFIQPGHLCCVRISEDKWWYRVIIHRVLEKQEVEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPVEEHWTSKAILQFQKLCGLKPLVGVVDEYVDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENISSKGFSELNPLALYTTSSGGPEDIVLTELGYPSQQHYFNEDRKISPQSKESELRILDEIPTGMPCLESVTIGDDIWDENWLPLQAKMGKGGDAASHLFTASLGGKNQYSSCKEMPQKDWCFSTPKDTWDDSWQPSGLVNGTKVEVHKPEVLGAQEKNTGTNRTQKQLDINGSSDSSTLPKLEEFCTSLTQSEQSADGSQSEPNNSQTQPKQIQLSTAAPCSTTAVDDSAEKPSGSVESSPEILKNEDFSSSRAITLYKDKRQESVDQLSLILSYECQISQKLYIPRSTATAALGAAARLATSRSLLHWYPSVKRMEA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 21 | Phosphorylation | EIRSLLISTKDGLSP HHHHHHHHCCCCCCH | 29.40 | 24719451 | |
| 110 | Phosphorylation | SMHKGRPSIYSGPRS CHHCCCCCCCCCCCC | 32.56 | 22210691 | |
| 112 | Phosphorylation | HKGRPSIYSGPRSHR HCCCCCCCCCCCCCC | 16.35 | 22210691 | |
| 117 | Phosphorylation | SIYSGPRSHRRVPYR CCCCCCCCCCCCCCC | 25.20 | 22210691 | |
| 195 | Phosphorylation | VEQTRAGSLLMLKKS EEHHHCCCEEEEEEC | 19.83 | 17081983 | |
| 440 | Phosphorylation | LQVETNKSELNLAMA EEEECCHHHHHHHHH | 49.76 | 22210691 | |
| 469 | Phosphorylation | CRLPPLDTSSLIGVF CCCCCCCHHHHHHHH | 28.09 | 24043423 | |
| 470 | Phosphorylation | RLPPLDTSSLIGVFV CCCCCCHHHHHHHHH | 23.86 | 24043423 | |
| 471 | Phosphorylation | LPPLDTSSLIGVFVE CCCCCHHHHHHHHHH | 26.54 | 24043423 | |
| 479 | Phosphorylation | LIGVFVEYIISPSQF HHHHHHHHCCCHHHE | 9.76 | 24043423 | |
| 482 | Phosphorylation | VFVEYIISPSQFYIR HHHHHCCCHHHEEEE | 14.67 | 24043423 | |
| 484 | Phosphorylation | VEYIISPSQFYIRIY HHHCCCHHHEEEEEE | 26.57 | 24043423 | |
| 487 | Phosphorylation | IISPSQFYIRIYSRD CCCHHHEEEEEEECC | 5.01 | 24043423 | |
| 492 | Phosphorylation | QFYIRIYSRDSSELL HEEEEEEECCHHHHH | 27.52 | 24719451 | |
| 495 | Phosphorylation | IRIYSRDSSELLEDM EEEEECCHHHHHHHH | 25.30 | - | |
| 510 | Phosphorylation | MIEMRRCYSNQLVSD HHHHHHHHCCCCCCC | 14.62 | - | |
| 511 | Phosphorylation | IEMRRCYSNQLVSDR HHHHHHHCCCCCCCC | 23.02 | - | |
| 516 | Phosphorylation | CYSNQLVSDRYVMPE HHCCCCCCCCCCCCH | 25.59 | - | |
| 709 | Phosphorylation | FNEDRKISPQSKESE CCCCCCCCCCCHHHH | 21.66 | 24719451 | |
| 734 (in isoform 1) | Phosphorylation | - | 28.64 | - | |
| 736 (in isoform 1) | Phosphorylation | - | 19.71 | - | |
| 747 (in isoform 1) | Phosphorylation | - | 7.87 | - | |
| 754 (in isoform 1) | Phosphorylation | - | 33.22 | - | |
| 822 | Phosphorylation | LGAQEKNTGTNRTQK CCCEECCCCCCCCEE | 57.35 | 29116813 | |
| 824 | Phosphorylation | AQEKNTGTNRTQKQL CEECCCCCCCCEEEE | 21.35 | 29116813 | |
| 827 | Phosphorylation | KNTGTNRTQKQLDIN CCCCCCCCEEEEECC | 42.03 | - | |
| 892 | Phosphorylation | STTAVDDSAEKPSGS CCCCCCCCCCCCCCC | 33.59 | - | |
| 913 | Phosphorylation | ILKNEDFSSSRAITL HHHCCCCCCCCCEEE | 39.46 | 24719451 | |
| 919 | Phosphorylation | FSSSRAITLYKDKRQ CCCCCCEEEECCCCC | 24.05 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TDRD5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TDRD5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TDRD5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TDRD5_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-195, AND MASSSPECTROMETRY. | |
