TCP4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCP4_RAT
• UniProt AC: Q63396
• Protein Name: Activated RNA polymerase II transcriptional coactivator p15
• Gene Name: Sub1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 127
• Subcellular Localization: Nucleus.
• Protein Description: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA) (By similarity)..
• Protein Sequence: MPKSKELVSSSSSGSDSDSEVEKKLKRKKQVVPEKPVKKQKPGESSRALASSKQSSSSRDDNMFQIGKMRYVSVRDFKGKILIDIREYWMDSEGEMKPGRKGISLNMEQWSQLKEQISDIDDAVRKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPKSKELVSSS ----CCCCHHHHCCC	26.03	-
9	Phosphorylation	PKSKELVSSSSSGSD CCCHHHHCCCCCCCC	36.81	28551015
10	Phosphorylation	KSKELVSSSSSGSDS CCHHHHCCCCCCCCC	27.10	28551015
11	Phosphorylation	SKELVSSSSSGSDSD CHHHHCCCCCCCCCH	22.48	28551015
12	Phosphorylation	KELVSSSSSGSDSDS HHHHCCCCCCCCCHH	40.44	28551015
13	Phosphorylation	ELVSSSSSGSDSDSE HHHCCCCCCCCCHHH	44.24	28551015
15	Phosphorylation	VSSSSSGSDSDSEVE HCCCCCCCCCHHHHH	35.57	28551015
17	Phosphorylation	SSSSGSDSDSEVEKK CCCCCCCCHHHHHHH	44.74	28551015
19	Phosphorylation	SSGSDSDSEVEKKLK CCCCCCHHHHHHHHH	47.71	28551015
35	Acetylation	KKQVVPEKPVKKQKP HCCCCCCCCCCCCCC	49.38	22902405
51	Phosphorylation	ESSRALASSKQSSSS HHHHHHHHHCCCCCC	38.63	25575281
52	Phosphorylation	SSRALASSKQSSSSR HHHHHHHHCCCCCCC	29.16	25575281
53	Acetylation	SRALASSKQSSSSRD HHHHHHHCCCCCCCC	52.26	25786129
55	Phosphorylation	ALASSKQSSSSRDDN HHHHHCCCCCCCCCC	35.60	29779826
56	Phosphorylation	LASSKQSSSSRDDNM HHHHCCCCCCCCCCC	29.82	27097102
57	Phosphorylation	ASSKQSSSSRDDNMF HHHCCCCCCCCCCCE	34.34	23984901
58	Phosphorylation	SSKQSSSSRDDNMFQ HHCCCCCCCCCCCEE	41.50	27097102
68	Acetylation	DNMFQIGKMRYVSVR CCCEEECCEEEEEEE	23.10	22902405
80	Acetylation	SVRDFKGKILIDIRE EEECCCCCEEEEEHH	34.62	22902405
92	Phosphorylation	IREYWMDSEGEMKPG EHHHEECCCCCCCCC	31.25	25575281
118	Phosphorylation	SQLKEQISDIDDAVR HHHHHHHHCHHHHHH	28.36	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCP4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCP4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCP4_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P53_RAT	Tp53	physical	17130840

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.