| UniProt ID | TCF23_HUMAN | |
|---|---|---|
| UniProt AC | Q7RTU1 | |
| Protein Name | Transcription factor 23 | |
| Gene Name | TCF23 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 214 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity).. | |
| Protein Sequence | MSQRKARGPPAMPGVGHSQTQAKARLLPGADRKRSRLSRTRQDPWEERSWSNQRWSRATPGPRGTRAGGLALGRSEASPENAARERSRVRTLRQAFLALQAALPAVPPDTKLSKLDVLVLAASYIAHLTRTLGHELPGPAWPPFLRGLRYLHPLKKWPMRSRLYAGGLGYSDLDSTTASTPSQRTRDAEVGSQVPGEADALLSTTPLSPALGDK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 38 | Phosphorylation | DRKRSRLSRTRQDPW HHHHHHHHCCCCCCC | 30.42 | 29485707 | |
| 66 | Methylation | TPGPRGTRAGGLALG CCCCCCCCCCCCCCC | 33.78 | 24410645 | |
| 66 | Dimethylation | TPGPRGTRAGGLALG CCCCCCCCCCCCCCC | 33.78 | - | |
| 75 | Phosphorylation | GGLALGRSEASPENA CCCCCCCCCCCHHHH | 35.40 | - | |
| 78 | Phosphorylation | ALGRSEASPENAARE CCCCCCCCHHHHHHH | 28.79 | - | |
| 87 | Phosphorylation | ENAARERSRVRTLRQ HHHHHHHHHHHHHHH | 30.30 | - | |
| 91 | Phosphorylation | RERSRVRTLRQAFLA HHHHHHHHHHHHHHH | 24.36 | - | |
| 161 | Phosphorylation | LKKWPMRSRLYAGGL CCCCCCCCCEECCCC | 22.01 | 29978859 | |
| 164 | Phosphorylation | WPMRSRLYAGGLGYS CCCCCCEECCCCCCC | 11.33 | 29978859 | |
| 170 | Phosphorylation | LYAGGLGYSDLDSTT EECCCCCCCCCCCCC | 12.21 | 29978859 | |
| 171 | Phosphorylation | YAGGLGYSDLDSTTA ECCCCCCCCCCCCCC | 29.87 | 29978859 | |
| 175 | Phosphorylation | LGYSDLDSTTASTPS CCCCCCCCCCCCCCC | 34.65 | 29978859 | |
| 176 | Phosphorylation | GYSDLDSTTASTPSQ CCCCCCCCCCCCCCC | 26.50 | 29978859 | |
| 177 | Phosphorylation | YSDLDSTTASTPSQR CCCCCCCCCCCCCCC | 23.67 | 29978859 | |
| 179 | Phosphorylation | DLDSTTASTPSQRTR CCCCCCCCCCCCCCC | 38.47 | 29978859 | |
| 180 | Phosphorylation | LDSTTASTPSQRTRD CCCCCCCCCCCCCCC | 25.21 | 29978859 | |
| 182 | Phosphorylation | STTASTPSQRTRDAE CCCCCCCCCCCCCCC | 32.17 | 29978859 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TCF23_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TCF23_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TCF23_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TCF23_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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