TCEA1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCEA1_RAT
• UniProt AC: Q4KLL0
• Protein Name: Transcription elongation factor A protein 1
• Gene Name: Tcea1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 301
• Subcellular Localization: Nucleus .
• Protein Description: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity)..
• Protein Sequence: MEDEVVRIAKKMDKMVQKKNAAGALDLLKELKNIPMTLELLQSTRIGMSVNAIRKQSTDEEVTSLAKSLIKSWKKLLDGPSTDKDSEEKKKEPAISSQNSPEAREESSSSSHVSSRKDETNARDTYVSSFPRAPSTSDSVRLKCREMLAAALRTGDDYVAIGADEEELGSQIEEAIYQEIRNTDMKYKNRVRSRISNLKDAKNPNLRKNVLCGNIPPDLFARMTAEEMASDELKEMRKNLTKEAIREHQMAKTGGTQTDLFTCGKCKKKNCTYTQVQTRSADEPMTTFVVCNECGNRWKFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDEVVRI -------CHHHHHHH	15.35	-
14	Acetylation	RIAKKMDKMVQKKNA HHHHHHHHHHHHCCH	37.16	-
57	Phosphorylation	VNAIRKQSTDEEVTS HHHHHHCCCHHHHHH	40.64	28432305
58	Phosphorylation	NAIRKQSTDEEVTSL HHHHHCCCHHHHHHH	44.96	28432305
67	Acetylation	EEVTSLAKSLIKSWK HHHHHHHHHHHHHHH	51.60	22902405
71	Acetylation	SLAKSLIKSWKKLLD HHHHHHHHHHHHHHC	56.40	22902405
75	Acetylation	SLIKSWKKLLDGPST HHHHHHHHHHCCCCC	48.28	22902405
81	Phosphorylation	KKLLDGPSTDKDSEE HHHHCCCCCCCCCHH	55.56	23984901
82	Phosphorylation	KLLDGPSTDKDSEEK HHHCCCCCCCCCHHH	50.64	23984901
84	Acetylation	LDGPSTDKDSEEKKK HCCCCCCCCCHHHHH	64.34	22902405
86	Phosphorylation	GPSTDKDSEEKKKEP CCCCCCCCHHHHHCC	54.09	23984901
96	Phosphorylation	KKKEPAISSQNSPEA HHHCCCCCCCCCHHH	28.16	23712012
97	Phosphorylation	KKEPAISSQNSPEAR HHCCCCCCCCCHHHH	27.54	23712012
100	Phosphorylation	PAISSQNSPEAREES CCCCCCCCHHHHHHH	19.24	23712012
126	Phosphorylation	ETNARDTYVSSFPRA CCCCHHHCHHCCCCC	11.56	22276854
135	Phosphorylation	SSFPRAPSTSDSVRL HCCCCCCCCCHHHHH	39.29	23984901
136	Phosphorylation	SFPRAPSTSDSVRLK CCCCCCCCCHHHHHH	35.18	23984901
137	Phosphorylation	FPRAPSTSDSVRLKC CCCCCCCCHHHHHHH	32.02	23984901
139	Phosphorylation	RAPSTSDSVRLKCRE CCCCCCHHHHHHHHH	14.65	23984901
186	Acetylation	EIRNTDMKYKNRVRS HHHCCCHHHHHHHHH	56.75	22902405
199	Acetylation	RSRISNLKDAKNPNL HHHHHCCCCCCCCCC	60.95	72629387
224	Phosphorylation	PDLFARMTAEEMASD HHHHHHHCHHHHCHH	25.93	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCEA1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCEA1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCEA1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TCEA1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.