TCAF1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCAF1_MOUSE
• UniProt AC: Q8BNE1
• Protein Name: TRPM8 channel-associated factor 1 {ECO:0000250|UniProtKB:Q9Y4C2}
• Gene Name: Tcaf1 {ECO:0000250|UniProtKB:Q9Y4C2, ECO:0000312|MGI:MGI:1914665}
• Organism: Mus musculus (Mouse).
• Sequence Length: 924
• Subcellular Localization: Cell membrane . Colocalizes with TRPM8 on the plasma membrane.
• Protein Description: Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner..
• Protein Sequence: MATPSAAFEALMNGVTSWDIPEDSVPCELLLIGEASFPIMVNDVGQVLVAASSYGRGRMVVASHEDFLLESQLFVFLVNAVGWLRSSPNSAIGVHSSLAPLVKILESCGIESKIEPEVNDSLGVYCIDAYNETMTDKLVQFVKRGGGLLIGGEAWDWDTQGDDDRVLFAFPGNLVTSVAGVYFTDNKADTSFFKVSKKMPKIPILVRCDDDLSDDRDELLRGIIDLDITNSDCFPSQLLVHGSLAFPLGLDTYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRKGKIVVQTELRTLSGLLAVGGIDTSIEPHLTSDASVYCFEPTSDVGVKELQEFVAEGGGLFVGTQAWWWAFKNPGVSPLARFPGNLLLNAFGISITSQSLNPGPFRTPKIGTRTYHFRSTLAEFQVIMGRKRGNVEKGWLAKLGPDGATFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRENPVINDCCRGAMLSLATGLAHSGSDLSLLIPEIEDVYSSRYLRPSASPITVNVNCTNPGTRYCWMSTGLYIPGRQVIDVSVPESAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLDKPTKSITCLWGGLLYIIVPQNSKLGSVPLTVKGAVRAPFYKLGETSKEEWKRRLLEYPGPWGELATDNIILTVPTANLRTLENPEPLLRLWDEMMQAVAKLGGETFPLRLPQRIVADVQISVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCNLWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPSVKHWNAWTALETYLQLQEAFGWEPFIRLFTEYRNQTTSSSPPSDNVDKMNLWVKMFSQQVQRNLAPFFEAWGWPIQKEVATSLAYLPEWKENIMKLYLLTQMPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
103	Ubiquitination	SSLAPLVKILESCGI HHHHHHHHHHHHCCC		-
143	Ubiquitination	DKLVQFVKRGGGLLI HHHHHHHHCCCCEEE		22790023
300	Ubiquitination	LDGGRKGKIVVQTEL HCCCCCCEEEEECCC		22790023
412	Phosphorylation	PKIGTRTYHFRSTLA CCCCCCEEEHHHHHH		28059163
417	Phosphorylation	RTYHFRSTLAEFQVI CEEEHHHHHHHHHHH		28059163
434	Ubiquitination	RKRGNVEKGWLAKLG CCCCCCCCCHHHHCC		22790023
521	Phosphorylation	EDVYSSRYLRPSASP HHHHCCCCCCCCCCC		28576409
605	Phosphorylation	CLDKPTKSITCLWGG CCCCCCCEEEEEECC		22871156
607	Phosphorylation	DKPTKSITCLWGGLL CCCCCEEEEEECCEE		22871156
630	Phosphorylation	KLGSVPLTVKGAVRA CCCCCCEEECCEEEC		22871156
647	Ubiquitination	YKLGETSKEEWKRRL HHCCCCCHHHHHHHH		22790023
651	Ubiquitination	ETSKEEWKRRLLEYP CCCHHHHHHHHHHCC		-
749	Phosphorylation	INEKLIRTKGLWGPV HHHHHHHCCCCCCCH		28059163
817	Ubiquitination	RVRIYLSKGPSVKHW EEEEEECCCCCCCCH		22790023
857	Phosphorylation	TEYRNQTTSSSPPSD HHHHCCCCCCCCCCC		29550500
858	Phosphorylation	EYRNQTTSSSPPSDN HHHCCCCCCCCCCCC		29550500
859	Phosphorylation	YRNQTTSSSPPSDNV HHCCCCCCCCCCCCH		29550500
860	Phosphorylation	RNQTTSSSPPSDNVD HCCCCCCCCCCCCHH		29550500
863	Phosphorylation	TTSSSPPSDNVDKMN CCCCCCCCCCHHHHH		29550500

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCAF1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCAF1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCAF1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TCAF1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.