| UniProt ID | TBX18_MOUSE | |
|---|---|---|
| UniProt AC | Q9EPZ6 | |
| Protein Name | T-box transcription factor TBX18 | |
| Gene Name | Tbx18 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 613 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart, the coronary vessels, the ureter, and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area.. | |
| Protein Sequence | MAEKRRGSPCSMLSLKAHAFSVEALIGAEKQQQLQKKRRKLATEEAAGAVEDAGCSRSGGAGEHGCSEADEEAAAPPPAAGAASGPARSCADAERSCGSRGAAGSCEDGFLQGASPLASPGGSPKGSPVPGLARPGTPLPAPQAPRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRMGLEALVESYAFWRPSLRTLTFEDIPGIPKQGNTSSSALLQGTGNAVPATHPHLLSGSSCSSPAFHLGPNTSQLCSLTPADYSACARSGLALNRYSTSLAETYSRLTNQSSETFAPPRTPSYVSVSSNPSVNMSMGGTDGDTFSCPQTSLSMQISGMSPQLQYIMPSPSGNAFAANQTHQSSYNTFRLHSPCALYGYNFSTSPKLAASPEKIVSSQGSFLGSSPSGTMTDRQMLPPVEGVHLLSSGGQQSFFDSRTLGSLTLPSSQVSAHMV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MAEKRRGSPCSMLSL CCCCCCCCCCCHHHH | 22.41 | 22942356 | |
| 115 | Phosphorylation | DGFLQGASPLASPGG CCCCCCCCCCCCCCC | 27.54 | 29550500 | |
| 119 | Phosphorylation | QGASPLASPGGSPKG CCCCCCCCCCCCCCC | 31.59 | 29550500 | |
| 123 | Phosphorylation | PLASPGGSPKGSPVP CCCCCCCCCCCCCCC | 29.38 | 29550500 | |
| 127 | Phosphorylation | PGGSPKGSPVPGLAR CCCCCCCCCCCCCCC | 28.93 | 24899341 | |
| 137 | Phosphorylation | PGLARPGTPLPAPQA CCCCCCCCCCCCCCC | 25.08 | 24899341 | |
| 337 | Phosphorylation | FAKGFRDSGRNRMGL CHHCCCCCCCCCCHH | 35.08 | 29514104 | |
| 531 | Phosphorylation | YNTFRLHSPCALYGY CCEEEEECCEEECCC | 26.68 | 29514104 | |
| 541 | Phosphorylation | ALYGYNFSTSPKLAA EECCCCCCCCHHHCC | 25.08 | 25338131 | |
| 543 | Phosphorylation | YGYNFSTSPKLAASP CCCCCCCCHHHCCCH | 20.88 | 29514104 | |
| 549 | Phosphorylation | TSPKLAASPEKIVSS CCHHHCCCHHHEECC | 28.16 | 22942356 | |
| 563 | Phosphorylation | SQGSFLGSSPSGTMT CCCCCCCCCCCCCCC | 41.02 | 25338131 | |
| 564 | Phosphorylation | QGSFLGSSPSGTMTD CCCCCCCCCCCCCCC | 22.68 | 29514104 | |
| 566 | Phosphorylation | SFLGSSPSGTMTDRQ CCCCCCCCCCCCCCC | 49.17 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TBX18_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TBX18_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TBX18_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TBX18_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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