TBC12_HUMAN - dbPTM
TBC12_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TBC12_HUMAN
UniProt AC O60347
Protein Name TBC1 domain family member 12
Gene Name TBC1D12
Organism Homo sapiens (Human).
Sequence Length 775
Subcellular Localization
Protein Description May act as a GTPase-activating protein for Rab family protein(s)..
Protein Sequence MVGPEDAGACSGRNPKLLPVPAPDPVGQDRKVIRATGGFGGGVGAVEPPEEADEEEEADEEEETPPRQLLQRYLAAAGEQLEPGLCYCPLPAGQAGAPPPSAAPRSDACLLGSGSKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLEEARGLARAGGRESRRRRPYGRLRLEGPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQEPEGAGSDSGDSPASSCSSSEDSEQRGVGAGGPEEGAPPATSAERTNGGAEPRLGFSDIHFNSRNTFQVSRGQSARDHLPPAGPPVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKRTKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKDIKEGDKNSSPALKS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MVGPEDAG
-------CCCHHHCC		7.6922814378
113PhosphorylationSDACLLGSGSKHRGA
CCCEECCCCCCCCCC		39.6021815630
115PhosphorylationACLLGSGSKHRGAEV
CEECCCCCCCCCCCC		27.3025159151
153MethylationCRDLEEARGLARAGG
CCCHHHHHHHHHCCC		43.89115918265
187PhosphorylationEDADGAGSPSDWASP
CCCCCCCCHHHHCCC		22.2429978859
189PhosphorylationADGAGSPSDWASPLE
CCCCCCHHHHCCCCC		47.7029978859
193PhosphorylationGSPSDWASPLEDPLR
CCHHHHCCCCCCHHH		26.2621712546
256PhosphorylationPATSAERTNGGAEPR
CCCCCCCCCCCCCCC		29.7124719451
267PhosphorylationAEPRLGFSDIHFNSR
CCCCCCCCCEEECCC		33.58-
284PhosphorylationFQVSRGQSARDHLPP
EEECCCCHHHHCCCC		28.26-
315PhosphorylationASARARRSGGFADFF
CCHHHHHHCCCHHHH		37.4022617229
335MethylationPKRTKELKSVVHSAP
CCCHHHHHHHHHCCC		42.15115980179
345MethylationVHSAPGWKLFGKVPP
HHCCCCCCCCCCCCC		39.59115980185
359PhosphorylationPRENLQKTSKIIQQE
CHHHHHHHHHHHHHH		23.4527174698
360PhosphorylationRENLQKTSKIIQQEY
HHHHHHHHHHHHHHH		28.9727174698
367PhosphorylationSKIIQQEYEARTGRT
HHHHHHHHHHHHCCC		15.5627174698
421PhosphorylationALRHRQEYDEMVAEA
HHHHHHHHHHHHHHH		14.6327642862
430AcetylationEMVAEAKKREIKEAH
HHHHHHHHHHHHHHH		63.417966035
434AcetylationEAKKREIKEAHKRKR
HHHHHHHHHHHHHHH		44.067966045
438AcetylationREIKEAHKRKRIMKE
HHHHHHHHHHHHHHH		67.667966055
524PhosphorylationKERWKSFSETSSEND
HHHHHHHHCCCCCCC		47.2428102081
526PhosphorylationRWKSFSETSSENDTE
HHHHHHCCCCCCCCC		36.0328102081
527PhosphorylationWKSFSETSSENDTEG
HHHHHCCCCCCCCCC		31.4428102081
528PhosphorylationKSFSETSSENDTEGV
HHHHCCCCCCCCCCC		48.0828348404
532PhosphorylationETSSENDTEGVSVAD
CCCCCCCCCCCCHHH		46.3428102081
707PhosphorylationGLGILRLYEDILLQM
CHHHHHHHHHHHHHC		12.72-
747PhosphorylationAAIQMQNSTKKWTQV
HHHHHHCCCHHHHHH		25.3922817900
748PhosphorylationAIQMQNSTKKWTQVF
HHHHHCCCHHHHHHH		44.1622817900
769PhosphorylationIKEGDKNSSPALKS-
HHCCCCCCCCCCCC-		43.3628348404
770PhosphorylationKEGDKNSSPALKS--
HCCCCCCCCCCCC--		24.4828348404
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TBC12_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TBC12_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TBC12_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TBC12_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TBC12_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-747 AND THR-748, ANDMASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, AND MASSSPECTROMETRY.

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