TBA1C_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBA1C_RAT
• UniProt AC: Q6AYZ1
• Protein Name: Tubulin alpha-1C chain
• Gene Name: Tuba1c
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 449
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain..
• Protein Sequence: MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLARVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGADSAEGDDEGEEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Acetylation	DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC	46.51	3325293
41	Phosphorylation	GQMPSDKTIGGGDDS CCCCCCCCCCCCCCC	29.82	27097102
48	Phosphorylation	TIGGGDDSFNTFFSE CCCCCCCCHHHCCCC	25.74	27097102
51	Phosphorylation	GGDDSFNTFFSETGA CCCCCHHHCCCCCCC	24.85	27097102
54	Phosphorylation	DSFNTFFSETGAGKH CCHHHCCCCCCCCCC	30.02	23984901
56	Phosphorylation	FNTFFSETGAGKHVP HHHCCCCCCCCCCCC	31.00	23984901
60	Acetylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	20679923
60	Ubiquitination	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	-
80	Phosphorylation	TVIDEVRTGTYRQLF EEEHHCCCCCCHHCC	38.77	23984901
82	Phosphorylation	IDEVRTGTYRQLFHP EHHCCCCCCHHCCCH	18.21	23984901
83	Phosphorylation	DEVRTGTYRQLFHPE HHCCCCCCHHCCCHH	9.56	23984901
96	Acetylation	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	30595941
96	Ubiquitination	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	-
103	Phosphorylation	KEDAANNYARGHYTI CHHHHHHCCCCCCCC	9.48	27097102
108	Phosphorylation	NNYARGHYTIGKEII HHCCCCCCCCCHHHH	11.68	27097102
109	Phosphorylation	NYARGHYTIGKEIID HCCCCCCCCCHHHHH	19.99	27097102
140	Phosphorylation	QGFLVFHSFGGGTGS CCEEEEEECCCCCCC	17.70	30240740
158	Phosphorylation	SLLMERLSVDYGKKS HHHHHHHCCCCCCCC	21.11	30240740
163	Ubiquitination	RLSVDYGKKSKLEFS HHCCCCCCCCCEEEE	47.87	-
163	Acetylation	RLSVDYGKKSKLEFS HHCCCCCCCCCEEEE	47.87	3325305
164	Ubiquitination	LSVDYGKKSKLEFSI HCCCCCCCCCEEEEE	48.75	-
210	Phosphorylation	MVDNEAIYDICRRNL EECHHHHHHHHHCCC	13.30	-
223	Phosphorylation	NLDIERPTYTNLNRL CCCCCCCCHHCHHHH	49.55	27097102
224	Phosphorylation	LDIERPTYTNLNRLI CCCCCCCHHCHHHHH	9.05	27097102
225	Phosphorylation	DIERPTYTNLNRLIS CCCCCCHHCHHHHHH	35.39	27097102
232	Phosphorylation	TNLNRLISQIVSSIT HCHHHHHHHHHHHHH	20.60	28689409
237	Phosphorylation	LISQIVSSITASLRF HHHHHHHHHHHHCCC	17.05	23984901
271	Phosphorylation	RIHFPLATYAPVISA CCCCCCCCCCCCCCH	28.09	30240740
272	Phosphorylation	IHFPLATYAPVISAE CCCCCCCCCCCCCHH	11.87	-
277	Phosphorylation	ATYAPVISAEKAYHE CCCCCCCCHHHHHHH	30.52	23984901
282	Nitrated tyrosine	VISAEKAYHEQLTVA CCCHHHHHHHCCCHH	19.56	-
282	Nitration	VISAEKAYHEQLTVA CCCHHHHHHHCCCHH	19.56	-
311	Ubiquitination	KCDPRHGKYMACCLL CCCCCCCCEEEEHHH	26.23	-
312	Phosphorylation	CDPRHGKYMACCLLY CCCCCCCEEEEHHHC	8.44	-
319	Phosphorylation	YMACCLLYRGDVVPK EEEEHHHCCCCCCCC	10.29	-
326	Ubiquitination	YRGDVVPKDVNAAIA CCCCCCCCCCHHHHH	63.80	-
326	Acetylation	YRGDVVPKDVNAAIA CCCCCCCCCCHHHHH	63.80	22632561
334	Phosphorylation	DVNAAIATIKTKRTI CCHHHHHHCCCCCEE	19.52	27097102
336	Ubiquitination	NAAIATIKTKRTIQF HHHHHHCCCCCEEEE	43.57	-
336	Acetylation	NAAIATIKTKRTIQF HHHHHHCCCCCEEEE	43.57	3325315
337	Phosphorylation	AAIATIKTKRTIQFV HHHHHCCCCCEEEEE	23.16	23984901
338	Ubiquitination	AIATIKTKRTIQFVD HHHHCCCCCEEEEEE	42.41	-
340	Phosphorylation	ATIKTKRTIQFVDWC HHCCCCCEEEEEEEC	22.23	23984901
357	Phosphorylation	GFKVGINYQPPTVVP CEEEEEECCCCCCCC	22.07	-
361	Phosphorylation	GINYQPPTVVPGGDL EEECCCCCCCCCCHH	40.60	-
394	Acetylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	3325343
394	Ubiquitination	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	-
399	Phosphorylation	DHKFDLMYAKRAFVH CCCCCHHHEEEHHHH	19.10	-
401	Ubiquitination	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	-
401	Acetylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	3325341
408	Phosphorylation	KRAFVHWYVGEGMEE EEHHHHHHCCCCCCC	5.45	25403869
432	Phosphorylation	MAALEKDYEEVGADS HHHHHHHHHHHCCCC	25.67	28689409
439	Phosphorylation	YEEVGADSAEGDDEG HHHHCCCCCCCCCCC	27.90	29779826
449	Nitration	GDDEGEEY------- CCCCCCCC-------	21.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBA1C_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
40	K	Acetylation	Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen.	-
40	K	Methylation	Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBA1C_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TBA1C_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.