TAU_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAU_BOVIN
• UniProt AC: P29172
• Protein Name: Microtubule-associated protein tau
• Gene Name: MAPT
• Organism: Bos taurus (Bovine).
• Sequence Length: 448
• Subcellular Localization: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Cytoplasm . Cell projection, dendrite . Mostly found in the axons of neurons, in the cytosol and in association with pla
• Protein Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization..
• Protein Sequence: MAEPRQEFDVMEDHAQGDYTLQDQEGDMDPGLKESPLQTPADDGSEEPGSETSDAKSTPTAEDATAPLVDEGAPGEQAAAQAPAEIPEGTAAEEAGIGDTSNLEDQAAGHVTQARMVSKGKDGTGPDDKKTKGADGKPGTKIATPRGAAPPGQKGQANATRIPAKTTPTPKTSPATMQVQKKPPPAGAKSERGESGKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSAAKSRLQAAPGPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEPRQEFD ------CCCCCCCCC	35.19	-
19	Phosphorylation	EDHAQGDYTLQDQEG CHHCCCCCCCCCCCC	19.04	-
35	Phosphorylation	MDPGLKESPLQTPAD CCCCCCCCCCCCCCC	29.35	-
50	Phosphorylation	DGSEEPGSETSDAKS CCCCCCCCCCCCCCC	48.71	-
58	Phosphorylation	ETSDAKSTPTAEDAT CCCCCCCCCCHHHCC	24.77	-
60	Phosphorylation	SDAKSTPTAEDATAP CCCCCCCCHHHCCCC	42.65	-
100	Phosphorylation	EEAGIGDTSNLEDQA HHCCCCCCCCHHHHH	17.82	-
144	Phosphorylation	KPGTKIATPRGAAPP CCCCEECCCCCCCCC	19.59	-
146	Methylation	GTKIATPRGAAPPGQ CCEECCCCCCCCCCC	42.92	-
154	"N6,N6-dimethyllysine"	GAAPPGQKGQANATR CCCCCCCCCCCCCCC	59.93	-
154	Acetylation	GAAPPGQKGQANATR CCCCCCCCCCCCCCC	59.93	-
154	Methylation	GAAPPGQKGQANATR CCCCCCCCCCCCCCC	59.93	-
160	Phosphorylation	QKGQANATRIPAKTT CCCCCCCCCCCCCCC	29.01	-
166	Phosphorylation	ATRIPAKTTPTPKTS CCCCCCCCCCCCCCC	39.86	-
167	Phosphorylation	TRIPAKTTPTPKTSP CCCCCCCCCCCCCCC	25.18	-
172	Phosphorylation	KTTPTPKTSPATMQV CCCCCCCCCCCEEEE	40.94	-
198	Phosphorylation	ERGESGKSGDRSGYS CCCCCCCCCCCCCCC	49.83	-
202	Phosphorylation	SGKSGDRSGYSSPGS CCCCCCCCCCCCCCC	46.99	-
204	Phosphorylation	KSGDRSGYSSPGSPG CCCCCCCCCCCCCCC	13.76	-
205	Phosphorylation	SGDRSGYSSPGSPGT CCCCCCCCCCCCCCC	33.31	-
206	Phosphorylation	GDRSGYSSPGSPGTP CCCCCCCCCCCCCCC	25.46	29541418
209	Phosphorylation	SGYSSPGSPGTPGSR CCCCCCCCCCCCCCC	24.44	29541418
212	Phosphorylation	SSPGSPGTPGSRSRT CCCCCCCCCCCCCCC	28.06	-
219	Phosphorylation	TPGSRSRTPSLPTPP CCCCCCCCCCCCCCC	20.62	-
221	Phosphorylation	GSRSRTPSLPTPPTR CCCCCCCCCCCCCCC	46.50	-
224	Phosphorylation	SRTPSLPTPPTREPK CCCCCCCCCCCCCCC	47.39	-
232	Acetylation	PPTREPKKVAVVRTP CCCCCCCEEEEEECC	46.25	-
238	Phosphorylation	KKVAVVRTPPKSPSA CEEEEEECCCCCHHH	32.12	-
242	Phosphorylation	VVRTPPKSPSAAKSR EEECCCCCHHHHHHH	29.84	-
244	Phosphorylation	RTPPKSPSAAKSRLQ ECCCCCHHHHHHHHH	48.20	-
266	Methylation	DLKNVKSKIGSTENL CHHHHHHHCCCCCCC	45.42	-
266	Acetylation	DLKNVKSKIGSTENL CHHHHHHHCCCCCCC	45.42	-
269	Phosphorylation	NVKSKIGSTENLKHQ HHHHHCCCCCCCCCC	35.70	-
288	Acetylation	KVQIINKKLDLSNVQ CEEEECCEECHHHHH	42.62	-
292	Phosphorylation	INKKLDLSNVQSKCG ECCEECHHHHHHHCC	34.32	-
296	Phosphorylation	LDLSNVQSKCGSKDN ECHHHHHHHCCCCCC	26.15	-
297	Acetylation	DLSNVQSKCGSKDNI CHHHHHHHCCCCCCC	26.06	-
300	Phosphorylation	NVQSKCGSKDNIKHV HHHHHCCCCCCCEEC	46.43	-
305	Acetylation	CGSKDNIKHVPGGGS CCCCCCCEECCCCCC	44.82	-
312	Phosphorylation	KHVPGGGSVQIVYKP EECCCCCCEEEEEEC	17.70	-
318	"N6,N6-dimethyllysine"	GSVQIVYKPVDLSKV CCEEEEEECCCHHHH	27.89	-
318	Acetylation	GSVQIVYKPVDLSKV CCEEEEEECCCHHHH	27.89	-
318	Methylation	GSVQIVYKPVDLSKV CCEEEEEECCCHHHH	27.89	-
324	Acetylation	YKPVDLSKVTSKCGS EECCCHHHHHHCCCC	57.75	-
328	Acetylation	DLSKVTSKCGSLGNI CHHHHHHCCCCCCCC	33.00	-
331	Phosphorylation	KVTSKCGSLGNIHHK HHHHCCCCCCCCCCC	42.44	-
338	Acetylation	SLGNIHHKPGGGQVE CCCCCCCCCCCCCEE	31.06	-
350	Acetylation	QVEVKSEKLDFKDRV CEEEEEEECCHHHHH	61.52	-
354	Acetylation	KSEKLDFKDRVQSKI EEEECCHHHHHHHHH	44.27	-
356	Methylation	EKLDFKDRVQSKIGS EECCHHHHHHHHHCC	29.03	-
359	Phosphorylation	DFKDRVQSKIGSLDN CHHHHHHHHHCCCCC	24.31	-
363	Phosphorylation	RVQSKIGSLDNITHV HHHHHHCCCCCCEEC	35.70	-
376	Acetylation	HVPGGGNKKIETHKL ECCCCCCCCCEEEEC	59.40	-
392	Acetylation	FRENAKAKTDHGAEI EHHHCCCCCCCCCEE	54.50	-
401	Phosphorylation	DHGAEIVYKSPVVSG CCCCEEEEECCCCCC	16.06	29541418
403	Phosphorylation	GAEIVYKSPVVSGDT CCEEEEECCCCCCCC	12.77	29541418
407	Phosphorylation	VYKSPVVSGDTSPRH EEECCCCCCCCCCCH	31.05	29541418
410	Phosphorylation	SPVVSGDTSPRHLSN CCCCCCCCCCCHHCC	44.12	29541418
411	Phosphorylation	PVVSGDTSPRHLSNV CCCCCCCCCCHHCCC	25.36	29541418
416	Phosphorylation	DTSPRHLSNVSSTGS CCCCCHHCCCCCCCC	29.12	28710545
419	Phosphorylation	PRHLSNVSSTGSIDM CCHHCCCCCCCCCCC	26.83	29541418
420	Phosphorylation	RHLSNVSSTGSIDMV CHHCCCCCCCCCCCC	32.29	29541418
421	Phosphorylation	HLSNVSSTGSIDMVD HHCCCCCCCCCCCCC	27.69	29541418
423	Phosphorylation	SNVSSTGSIDMVDSP CCCCCCCCCCCCCCH	18.59	29541418
429	Phosphorylation	GSIDMVDSPQLATLA CCCCCCCCHHHHHHH	11.79	-
434	Phosphorylation	VDSPQLATLADEVSA CCCHHHHHHHHHHHH	30.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
202	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	PSP
209	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	PSP
212	T	Phosphorylation	Kinase	TTBK1	Q5TCY1	PSP
242	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	PSP
403	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	PSP
411	S	Phosphorylation	Kinase	TTBK1	Q5TCY1	PSP
423	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
423	S	Phosphorylation	Kinase	CAMK-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAU_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAU_BOVIN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBA4A_HUMAN	TUBA4A	physical	19681044

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.