TAF6_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAF6_RAT
• UniProt AC: Q63801
• Protein Name: Transcription initiation factor TFIID subunit 6
• Gene Name: Taf6
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 678
• Subcellular Localization: Nucleus.
• Protein Description: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (By similarity)..
• Protein Sequence: MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVSYRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKPGQEEDGPLKGKGQGAAAADGKGKEKKAPPLLEGAPFRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRGEFGSLGPLLCSHVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSASSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPAGPGSVQKYIVVSLPPTGEGKGGPPSHPSPVPPSSSSPSPLGGSALCGGKQETGDSPPPAPGTPKANGSQPTGPSSPQPAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	Phosphorylation	DLSDIINTPLPRVPL CHHHHCCCCCCCCCH	18.78	-
191	Ubiquitination	GAAAADGKGKEKKAP CCCCCCCCCCCCCCC	68.32	-
248	Phosphorylation	EALQSIATDPGLYQM HHHHHHCCCHHHHHH	40.85	16641100
253	Phosphorylation	IATDPGLYQMLPRFS HCCCHHHHHHHHHHH	9.59	16641100
264	Phosphorylation	PRFSTFISEGVRVNV HHHHHHHCCCCCCEE	24.89	16641100
281	Phosphorylation	NNLALLIYLMRMVKA CHHHHHHHHHHHHHH	8.40	16641100
503	Phosphorylation	APQPGPRTPGLLKVP CCCCCCCCCCCEECC	25.49	22108457
524	Methylation	VQTLVSARAAAPPQP HHHHHHHHHCCCCCC	19.77	-
532	Phosphorylation	AAAPPQPSPPPTKFI HCCCCCCCCCCCEEE	44.80	27097102
536	Phosphorylation	PQPSPPPTKFIVMSS CCCCCCCCEEEEEEC	44.34	27097102
623	Phosphorylation	EGKGGPPSHPSPVPP CCCCCCCCCCCCCCC	51.68	27097102
626	Phosphorylation	GGPPSHPSPVPPSSS CCCCCCCCCCCCCCC	32.86	27097102
631	Phosphorylation	HPSPVPPSSSSPSPL CCCCCCCCCCCCCCC	36.46	27097102
632	Phosphorylation	PSPVPPSSSSPSPLG CCCCCCCCCCCCCCC	40.38	27097102
633	Phosphorylation	SPVPPSSSSPSPLGG CCCCCCCCCCCCCCC	51.08	27097102
634	Phosphorylation	PVPPSSSSPSPLGGS CCCCCCCCCCCCCCC	31.20	27097102
636	Phosphorylation	PPSSSSPSPLGGSAL CCCCCCCCCCCCCCC	34.40	27097102
641	Phosphorylation	SPSPLGGSALCGGKQ CCCCCCCCCCCCCCC	19.10	27097102
650	Phosphorylation	LCGGKQETGDSPPPA CCCCCCCCCCCCCCC	43.74	27097102
653	Phosphorylation	GKQETGDSPPPAPGT CCCCCCCCCCCCCCC	40.42	23712012
660	Phosphorylation	SPPPAPGTPKANGSQ CCCCCCCCCCCCCCC	22.13	21738781
669	Phosphorylation	KANGSQPTGPSSPQP CCCCCCCCCCCCCCC	54.83	23984901
672	Phosphorylation	GSQPTGPSSPQPAL- CCCCCCCCCCCCCC-	56.87	27097102
673	Phosphorylation	SQPTGPSSPQPAL-- CCCCCCCCCCCCC--	30.59	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAF6_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAF6_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAF6_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TAF6_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.