TAF2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAF2_SCHPO
• UniProt AC: P87121
• Protein Name: Transcription initiation factor TFIID subunit 2
• Gene Name: taf2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1172
• Subcellular Localization: Cytoplasm . Nucleus . Localizes at the barrier septum.
• Protein Description: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by taf1), facilitation of DNA opening and initiation of transcription (By similarity)..
• Protein Sequence: MSQLVDVPARGHQKVAIDIDFASQTIIGRTDITVNPIDSNLQKIVLDCYQAEIHSVYVNGDLTKFSYSDALKKLRIDEPNSTVNQHHQLNLQYEALMNDLGGINIFLSKPPGDELRPLIVSIDFSVHQPIFGITFVGIDPVDHRYPHVFTNNSIIPYSTCSWLPCVDGIWERSTWEFEITLPKTLSSLMHREKTQPSDLNNGANGVDGHDDNYENNRFDHQFNLSNEPDLLEDHDIEVICCGDLLDQVTHPKDMRKKTVYFSVTTPVAPNYIAFAAGPFKHINLTDFREPEDDDAMGSSAIDITGYYLPKYAEEVENTCVFLYKAMDFFVREYGSYPFNSFKLCFVDETNFPIISTPSLVISSNSILYPKDSLDQIYDSTKTLTWALASQWIGVYLIPKAWSDLWLIYGLSYYICGLFLKKLMGNNDYRFRLKKQVYRLLELDIGKPPISQRNINIPIDPNTLDFIALKSPLVIHILERRLTKTGGSLGMSRVIPKLLLQVMSGDMLNGCLSTSHFLKTCEKASHMRLDVFAQQWIYGYGYPIFRVVQRFNRKKMIIEMGIDQVQTKEAPRAPMSDKNFLSDAIRHLNNESIPTGLPVFSGPMTIRIHEADGTPYEHVVELKDSFTKLDIQYNTKYKRISRNRSTKNVKRDGDHNGDDSDYVIRSLGDVLQSDEDIERWHLYDYTKEEEDTMATEAFEWIRVDADFEWICDLRVRQPEHMYVSQLQQDRDVVAQLETIRHFTSESFTVSQQVSTVLLRTLLDNRYYYGIRQEAARALARCAIPELDWVGYYHLRMAYLEKFCFKDSTIPKSNDFSNITEYYVKCAMLESFPNIRDRKGVTPSSVKKLLLDLLCYNDNANNEFSDAYFICLLIDSLVEGLIPRGETVQYAFSDPEHMEFVNQVINEIDRYMRIDACMPSFKNIITCKSLKAKLRLAQTFHLEFGPKELLPYTQEGNYVLVRCIAFNLMLQAGALKYTPLIKYIFYILTNDLSPVVRRSLLYSVQDGLGALARGGTKSDVASEDLIVEEDITKAVEKRIDITSRASISGAIEALRNDLGQNHDFATEIWNAINNPKSDLLTKRNLLMICRVLYKAKSSLLVTLKIPSLIPRLRAIHLGKGKIVIKKAPLKQITSKTKEKSTSPTPPSITINPIKPKGPTLKIKLTNLRSTPPSH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
665	Phosphorylation	DSDYVIRSLGDVLQS CCHHHHHHHHHHHCC	26.11	25720772
672	Phosphorylation	SLGDVLQSDEDIERW HHHHHHCCCCCHHHH	38.51	28889911
1138	Phosphorylation	TSKTKEKSTSPTPPS CCCCCCCCCCCCCCC	34.90	24763107
1139	Phosphorylation	SKTKEKSTSPTPPSI CCCCCCCCCCCCCCE	50.20	25720772
1140	Phosphorylation	KTKEKSTSPTPPSIT CCCCCCCCCCCCCEE	33.59	25720772
1142	Phosphorylation	KEKSTSPTPPSITIN CCCCCCCCCCCEEEC	47.82	29996109
1145	Phosphorylation	STSPTPPSITINPIK CCCCCCCCEEECCCC	33.30	25720772
1147	Phosphorylation	SPTPPSITINPIKPK CCCCCCEEECCCCCC	21.02	25720772
1163	Phosphorylation	PTLKIKLTNLRSTPP CEEEEEEECCCCCCC	27.49	24763107
1167	Phosphorylation	IKLTNLRSTPPSH-- EEEECCCCCCCCC--	48.72	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAF2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAF2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAF2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COQ5_SCHPO	coq5	genetic	22681890

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.