TACHY_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TACHY_DROME
• UniProt AC: Q9VGE8
• Protein Name: Tachykinins
• Gene Name: Tk {ECO:0000312|EMBL:AAF54735.1}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 289
• Subcellular Localization: Secreted .
• Protein Description: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Stimulates gut muscle contractions. [PubMed: 10801863 Required for the response to the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males]
• Protein Sequence: MRPLSGLIALALLLLLLLTAPSSAADTETESSGSPLTPGAEEPRRVVKRAPTSSFIGMRGKKDEEHDTSEGNWLGSGPDPLDYADEEADSSYAENGRRLKKAPLAFVGLRGKKFIPINNRLSDVLQSLEEERLRDSLLQDFFDRVAGRDGSAVGKRAPTGFTGMRGKRPALLAGDDDAEADEATELQQKRAPVNSFVGMRGKKDVSHQHYKRAALSDSYDLRGKQQRFADFNSKFVAVRGKKSDLEGNGVGIGDDHEQALVHPWLYLWGEKRAPNGFLGMRGKRPALFE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Arginine amide	TSSFIGMRGKKDEEH CCCCCCCCCCCCCCC	48.87	-
59	Amidation	TSSFIGMRGKKDEEH CCCCCCCCCCCCCCC	48.87	21214272
95	Asparagine amide	ADSSYAENGRRLKKA HHHHHHHHCCCCCCC	40.89	-
95	Amidation	ADSSYAENGRRLKKA HHHHHHHHCCCCCCC	40.89	10801863
110	Arginine amide	PLAFVGLRGKKFIPI CEEEEECCCCEEEEC	49.29	-
110	Amidation	PLAFVGLRGKKFIPI CEEEEECCCCEEEEC	49.29	21214272
153	Valine amide	AGRDGSAVGKRAPTG CCCCCCCCCCCCCCC	11.27	-
153	Amidation	AGRDGSAVGKRAPTG CCCCCCCCCCCCCCC	11.27	10801863
165	Arginine amide	PTGFTGMRGKRPALL CCCCCCCCCCCCCCC	49.15	-
165	Amidation	PTGFTGMRGKRPALL CCCCCCCCCCCCCCC	49.15	21214272
200	Arginine amide	VNSFVGMRGKKDVSH CCCCCCCCCCCCCCH	48.10	-
200	Amidation	VNSFVGMRGKKDVSH CCCCCCCCCCCCCCH	48.10	21214272
239	Arginine amide	NSKFVAVRGKKSDLE CCCEEEEECCCHHCC	41.28	-
239	Amidation	NSKFVAVRGKKSDLE CCCEEEEECCCHHCC	41.28	10801863
281	Arginine amide	PNGFLGMRGKRPALF CCCCCCCCCCCCCCC	45.76	-
281	Amidation	PNGFLGMRGKRPALF CCCCCCCCCCCCCCC	45.76	21214272

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TACHY_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TACHY_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TACHY_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GYS_DROME	GlyS	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.