TAB2_MOUSE - dbPTM
TAB2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TAB2_MOUSE
UniProt AC Q99K90
Protein Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Gene Name Tab2
Organism Mus musculus (Mouse).
Sequence Length 693
Subcellular Localization Nucleus . Cytoplasm, cytosol . Cytoplasmic when activated. Following IL1 stimulation, localized in the to cytosol.
Protein Description Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187' (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development (By similarity)..
Protein Sequence MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDESGISGLRNHMTSLNLDLQSQNVYHHGREGSRVNGSRTLTHSVSDGQLHGGQSNNELFQQEPQTAPAQVPQGFNVFGMPSTSGASNSTPHLGFHLGSKGTSNLSQQTPRFNPIMVTLAPNIQTGRSTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPSGTARQTQQHSGWVSQFNPMNPQQAYQPSQPGPWTTYPASNPLPHTSTQQPNQQGHQTSHVYMPISSPTTPQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNSSSKLRSSGPRTASTSSLVNSQTLNRNQPTVYIAASPPNTDEMISRSQPKVYISANATAGDEQGMRNQPTLFISTNSGPSAASRNMSGQVSMGPAFIHHHPPKSRVLGGNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPALAHVDRISEARKLSMGSDDAAYTQALLVHQKARMERLQRELEMQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSTIKAPKTQDAEDEEGAQWNCTACTFLNHPALIRCEQCEMPRHF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
173MethylationNLSQQTPRFNPIMVT
CHHHCCCCCCCEEEE		47.5724129315
173Asymmetric dimethylarginineNLSQQTPRFNPIMVT
CHHHCCCCCCCEEEE		47.57-
348PhosphorylationLRSSGPRTASTSSLV
CCCCCCCCCCCHHHH		28.2623970565
350PhosphorylationSSGPRTASTSSLVNS
CCCCCCCCCHHHHCH		28.3626643407
351PhosphorylationSGPRTASTSSLVNSQ
CCCCCCCCHHHHCHH		21.6328066266
352PhosphorylationGPRTASTSSLVNSQT
CCCCCCCHHHHCHHC		21.1226643407
359PhosphorylationSSLVNSQTLNRNQPT
HHHHCHHCCCCCCCE		26.3129514104
372PhosphorylationPTVYIAASPPNTDEM
CEEEEEECCCCHHHC		31.6925266776
376PhosphorylationIAASPPNTDEMISRS
EEECCCCHHHCHHCC		38.8326643407
381PhosphorylationPNTDEMISRSQPKVY
CCHHHCHHCCCCEEE		25.2726643407
447PhosphorylationSRVLGGNSATSPRVV
HHCCCCCCCCCCEEE		35.8829472430
449PhosphorylationVLGGNSATSPRVVVT
CCCCCCCCCCEEEEE		38.8020469934
450PhosphorylationLGGNSATSPRVVVTQ
CCCCCCCCCEEEEEC		15.4926824392
456O-linked_GlycosylationTSPRVVVTQPNTKYT
CCCEEEEECCCCEEE		27.0530059200
456PhosphorylationTSPRVVVTQPNTKYT
CCCEEEEECCCCEEE		27.05-
467PhosphorylationTKYTFKITVSPNKPP
CEEEEEEEECCCCCC		18.6025367039
469PhosphorylationYTFKITVSPNKPPAV
EEEEEEECCCCCCCC		17.6925367039
477PhosphorylationPNKPPAVSPGVVSPT
CCCCCCCCCCCCCCC		20.3125367039
482PhosphorylationAVSPGVVSPTFELTN
CCCCCCCCCCEEHHH		18.8025367039
484PhosphorylationSPGVVSPTFELTNLL
CCCCCCCCEEHHHHH		23.4125367039
488PhosphorylationVSPTFELTNLLNHPD
CCCCEEHHHHHCCCC		19.3425367039
497PhosphorylationLLNHPDHYVETENIQ
HHCCCCCEEECCCHH		13.8325367039
500PhosphorylationHPDHYVETENIQHLT
CCCCEEECCCHHHCC		25.0425367039
524PhosphorylationISEARKLSMGSDDAA
HHHHHHHCCCCCCHH		24.9225521595
527PhosphorylationARKLSMGSDDAAYTQ
HHHHCCCCCCHHHHH		24.5526824392
532PhosphorylationMGSDDAAYTQALLVH
CCCCCHHHHHHHHHH		10.9128833060
533PhosphorylationGSDDAAYTQALLVHQ
CCCCHHHHHHHHHHH		11.5728833060
563PhosphorylationKKLDKLKSEVNEMEN
HHHHHHHHHHHHHHH		58.1623737553
573PhosphorylationNEMENNLTRRRLKRS
HHHHHHHHHHHHHHC		25.0123737553
580PhosphorylationTRRRLKRSNSISQIP
HHHHHHHCCCHHHCC		33.0825266776
582PhosphorylationRRLKRSNSISQIPSL
HHHHHCCCHHHCCCH		25.5123527152
584PhosphorylationLKRSNSISQIPSLEE
HHHCCCHHHCCCHHH		23.1326643407
588PhosphorylationNSISQIPSLEEMQQL
CCHHHCCCHHHHHHH		50.4725777480
597PhosphorylationEEMQQLRSCNRQLQI
HHHHHHHHCCCCCEE		25.0830635358
611UbiquitinationIDIDCLTKEIDLFQA
EEHHHHHCCCCHHHH		39.46-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TAB2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TAB2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TAB2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBC_MOUSEUbcphysical
19136968
M3K7_MOUSEMap3k7physical
19843958
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TAB2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-450, AND MASSSPECTROMETRY.

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