TAAR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAAR1_HUMAN
• UniProt AC: Q96RJ0
• Protein Name: Trace amine-associated receptor 1
• Gene Name: TAAR1
• Organism: Homo sapiens (Human).
• Sequence Length: 339
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase..
• Protein Sequence: MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	N-linked_Glycosylation	PFCHNIINISCVKNN CCCCEEEEEHHHCCC	19.14	UniProtKB CARBOHYD
12	Phosphorylation	CHNIINISCVKNNWS CCEEEEEHHHCCCCC	14.36	26270265
17	N-linked_Glycosylation	NISCVKNNWSNDVRA EEHHHCCCCCHHHHH	37.52	UniProtKB CARBOHYD
67	Phosphorylation	WLIHSMATVDFLLGC HHHHHHHHHHHHHHH	16.38	-
134	Methylation	DPLRYKAKMNILVIC CHHHHHHHHCHHHHH	28.47	-
147	Phosphorylation	ICVMIFISWSVPAVF HHHHHHHCCCHHHHH	11.53	22210691
149	Phosphorylation	VMIFISWSVPAVFAF HHHHHCCCHHHHHHH	16.07	22210691
322	Acetylation	LKMMLFGKIFQKDSS HHHHHHHHHHHCCCH	32.77	7695541

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAAR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAAR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAAR1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TAAR1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.