T2FA_RAT - dbPTM
T2FA_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID T2FA_RAT
UniProt AC Q6AY96
Protein Name General transcription factor IIF subunit 1
Gene Name Gtf2f1
Organism Rattus norvegicus (Rat).
Sequence Length 508
Subcellular Localization Nucleus.
Protein Description TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation (By similarity)..
Protein Sequence MAALGSSSQNVTEYVVRVPKNTAKRYNIMAFNAADKVNFATWNQARLERDLSNKKIYQEEEMPESGAGSEFNRKLREEARRKKYGIVLKEFRPEDQPWLLRVNGKSGRKFKGIKKGGVTENTAYYIFTQCADGAFEAFPVQNWYNFTPLARHRTLTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRSRKKPSELRIHDLEDDLEMSSDASDASGEEGSRASKAKKKAPVTKAGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSPDEAEGKPKVPQQEDGPKGVDEQSESSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSDDSDSSEESDIDSETSSALFMAKKKTPPKRERKPSGGSSKGTSRPGTPSAEAASTSSTLRAAASKLEQGKRTSETPAAKRLRMDTGPQSLSGKSTPSSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTKKTGLSSEQTVNVLAQILKRLNPERKMIGDKMHFSLKE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAALGSSSQ
------CCCCCCCCC		16.05-
114AcetylationGRKFKGIKKGGVTEN
CCCCCCCEECCCCCC		54.7722902405
154PhosphorylationTPLARHRTLTAEEAE
CCCCCCCCCCHHHHH		23.4928432305
156PhosphorylationLARHRTLTAEEAEEE
CCCCCCCCHHHHHHH		31.2628432305
200AcetylationEKEKRSRKKPSELRI
HHHHHHCCCCCCCCE		70.9922902405
203PhosphorylationKRSRKKPSELRIHDL
HHHCCCCCCCCEECH		59.1326022182
217PhosphorylationLEDDLEMSSDASDAS
HHHHHHHCCCCCCCC		18.7227097102
218PhosphorylationEDDLEMSSDASDASG
HHHHHHCCCCCCCCC		35.5727097102
221PhosphorylationLEMSSDASDASGEEG
HHHCCCCCCCCCCCC		38.4127097102
224PhosphorylationSSDASDASGEEGSRA
CCCCCCCCCCCCHHH		52.2927097102
229PhosphorylationDASGEEGSRASKAKK
CCCCCCCHHHHHHHH		28.1427097102
331PhosphorylationEEEKKAPTPQEKKRR
HHHHHCCCHHHHHHH		42.3329779826
342PhosphorylationKKRRKDSSDDSDSSE
HHHHCCCCCCCCCCC		56.4216641100
348PhosphorylationSSDDSDSSEESDIDS
CCCCCCCCCHHHCCH		50.8316641100
351PhosphorylationDSDSSEESDIDSETS
CCCCCCHHHCCHHHH		35.5016641100
355PhosphorylationSEESDIDSETSSALF
CCHHHCCHHHHHHHH		43.0116641100
358PhosphorylationSDIDSETSSALFMAK
HHCCHHHHHHHHHHC		15.0116641100
377PhosphorylationPKRERKPSGGSSKGT
CCCCCCCCCCCCCCC		59.8428689409
380PhosphorylationERKPSGGSSKGTSRP
CCCCCCCCCCCCCCC		32.1928689409
381PhosphorylationRKPSGGSSKGTSRPG
CCCCCCCCCCCCCCC		38.08-
384PhosphorylationSGGSSKGTSRPGTPS
CCCCCCCCCCCCCCC		25.8727097102
385PhosphorylationGGSSKGTSRPGTPSA
CCCCCCCCCCCCCCH		45.1828689409
389PhosphorylationKGTSRPGTPSAEAAS
CCCCCCCCCCHHHHC		19.4328689409
391PhosphorylationTSRPGTPSAEAASTS
CCCCCCCCHHHHCCH		38.2827097102
396PhosphorylationTPSAEAASTSSTLRA
CCCHHHHCCHHHHHH		35.5527097102
397PhosphorylationPSAEAASTSSTLRAA
CCHHHHCCHHHHHHH		23.2127097102
398PhosphorylationSAEAASTSSTLRAAA
CHHHHCCHHHHHHHH		20.8727097102
399PhosphorylationAEAASTSSTLRAAAS
HHHHCCHHHHHHHHH		31.3927097102
400PhosphorylationEAASTSSTLRAAASK
HHHCCHHHHHHHHHH		21.7427097102
407AcetylationTLRAAASKLEQGKRT
HHHHHHHHHHHCCCC		51.8525786129
427PhosphorylationAKRLRMDTGPQSLSG
HHHHHCCCCCCCCCC		41.2228432305
431PhosphorylationRMDTGPQSLSGKSTP
HCCCCCCCCCCCCCC		27.8627097102
433PhosphorylationDTGPQSLSGKSTPSS
CCCCCCCCCCCCCCC		49.8027097102
436PhosphorylationPQSLSGKSTPSSGDV
CCCCCCCCCCCCCCC		49.4227097102
437PhosphorylationQSLSGKSTPSSGDVQ
CCCCCCCCCCCCCCC		30.5827097102
439PhosphorylationLSGKSTPSSGDVQVT
CCCCCCCCCCCCCCC		47.2227097102
440PhosphorylationSGKSTPSSGDVQVTE
CCCCCCCCCCCCCCH		39.9727097102
446PhosphorylationSSGDVQVTEDAVRRY
CCCCCCCCHHHHHHH		15.8527097102
453PhosphorylationTEDAVRRYLTRKPMT
CHHHHHHHHHCCCCC		11.2328689409
460PhosphorylationYLTRKPMTTKDLLKK
HHHCCCCCHHHHHHH		38.9428689409
461PhosphorylationLTRKPMTTKDLLKKF
HHCCCCCHHHHHHHH		19.1328689409
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of T2FA_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of T2FA_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of T2FA_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of T2FA_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of T2FA_RAT

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Related Literatures of Post-Translational Modification

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