T176B_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T176B_RAT
• UniProt AC: Q925D4
• Protein Name: Transmembrane protein 176B
• Gene Name: Tmem176b
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 263
• Subcellular Localization: Nucleus membrane ; Multi-pass membrane protein .
• Protein Description: Required for the development of cerebellar granule cells (By similarity). May play a role in the process of maturation of dendritic cells..
• Protein Sequence: MAQATVTVDGVKVTSTRPQSAQISIHIHHKSALEQLLGAMGSLKKFLSYPQARIHYGQLSLGVTQILLGLVSCVLGVCLYFGPWTELCASGCAFWSGSVAILAGVGIVIHEMGQGKLSGHISRLLLLACSATAAAATVMGVKSLIWQTSASYYFEISSTCDSLQPSIVDRFRSVRFTDDSDWRTERCREYLRMMMNLFLAFCILFTVICILKIVVSVASLGLSLRSMCGRNSQVLNDEETEKKLLGGDSAPASPTKEKIPVTP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
243	Ubiquitination	NDEETEKKLLGGDSA CCHHHHHHHHCCCCC	42.59	-
249	Phosphorylation	KKLLGGDSAPASPTK HHHHCCCCCCCCCCC	39.15	27097102
253	Phosphorylation	GGDSAPASPTKEKIP CCCCCCCCCCCCCCC	31.85	27097102
255	Phosphorylation	DSAPASPTKEKIPVT CCCCCCCCCCCCCCC	49.71	27097102
256	Ubiquitination	SAPASPTKEKIPVTP CCCCCCCCCCCCCCC	61.47	-
262	Phosphorylation	TKEKIPVTP------ CCCCCCCCC------	20.23	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T176B_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T176B_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T176B_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of T176B_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.