T132D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T132D_HUMAN
• UniProt AC: Q14C87
• Protein Name: Transmembrane protein 132D
• Gene Name: TMEM132D
• Organism: Homo sapiens (Human).
• Sequence Length: 1099
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: May serve as a cell-surface marker for oligodendrocyte differentiation..
• Protein Sequence: MCPSEMGTLWHHWSPVLISLAALFSKVTEGRGILESIQRFSLLPTYLPVTYHINNADVSFFLKEANQDIMRNSSLQSRVESFLIYKSRRLPVLNASYGPFSIEQVVPQDLMLPSNPFGFTNKFSLNWKLKAHILRDKVYLSRPKVQVLFHIMGRDWDDRSAGEKLPCLRVFAFRETREVRGSCRLQGDLGLCVAELELLSSWFSPPTVVAGRRKSVDQPEGTPVELYYTVHPGGERGDCVREDARRSNGIRTGHSDIDESGPPLQRIGSIFLYQTHRKPSLRELRLDNSVAIHYIPKTVRKGDVLTFPVSISRNSTEDRFTLRAKVKKGVNIIGVRASSPSIWDVKERTDYTGKYAPAVIVCQKKAAGSENSADGASYEVMQIDVEVEEPGDLPATQLVTWQVEYPGEITSDLGVSKIYVSPKDLIGVVPLAMEAEILNTAILTGKTVAVPVKVVSVEDDGTVTELLESVECRSSDEDVIKVSDRCDYVFVNGKEMKGKVNVVVNFTYQHLSSPLEMTVWVPRLPLQIEVSDTELNQIKGWRVPIVSSRRPAGDSEEEEDDERRGRGCTLQYQHAMVRVLTQFVAEAAGPGGHLAHLLGSDWQVDITELINDFMQVEEPRIAKLQGGQILMGQELGMTTIQILSPLSDTILAEKTITVLDEKVTITDLGVQLVTGLSLSLQLSPGSNRAIFATAVAQELLQRPKQEAAISCWVQFSDGSVTPLDIYDGKDFSLMATSLDEKVVSIHQDPKFKWPIIAAETEGQGTLVKVEMVISESCQKSKRKSVLAVGTANIKVKFGQNDANPNTSDSRHTGAGVHMENNVSDRRPKKPSQEWGSQEGQYYGSSSMGLMEGRGTTTDRSILQKKKGQESLLDDNSHLQTIPSDLTSFPAQVDLPRSNGEMDGNDLMQASKGLSDLEIGMYALLGVFCLAILVFLINCVTFALKYRHKQVPFEEQEGMSHSHDWVGLSNRTELLENHINFASSQDEQITAIDRGMDFEESKYLLSTNSQKSINGQLFKPLGPIIIDGKDQKSEPPTSPTSKRKRVKFTTFTAVSSDDEYPTRNSIVMSSEDDIKWVCQDLDPGDCKELHNYMERLHENV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	ISLAALFSKVTEGRG HHHHHHHHHHHCCCC	27.37	24719451
28	Phosphorylation	AALFSKVTEGRGILE HHHHHHHHCCCCHHH	36.14	-
85	Phosphorylation	RVESFLIYKSRRLPV HHHHHHHHHHCCCCE	12.69	-
87	Phosphorylation	ESFLIYKSRRLPVLN HHHHHHHHCCCCEEC	12.98	-
128 (in isoform 1)	Ubiquitination	-	38.75	21890473
128	Ubiquitination	NKFSLNWKLKAHILR CCCCCCEEEEEEEEC	38.75	21890473
310	Phosphorylation	DVLTFPVSISRNSTE CEEEEEEEECCCCCC	18.32	-
312	Phosphorylation	LTFPVSISRNSTEDR EEEEEEECCCCCCCC	20.22	24719451
315	Phosphorylation	PVSISRNSTEDRFTL EEEECCCCCCCCEEE	31.87	-
321	Phosphorylation	NSTEDRFTLRAKVKK CCCCCCEEEEEEECC	19.07	24719451
338	Phosphorylation	NIIGVRASSPSIWDV EEEEEECCCCCCEEC	32.02	-
339	Phosphorylation	IIGVRASSPSIWDVK EEEEECCCCCCEECC	22.98	-
341	Phosphorylation	GVRASSPSIWDVKER EEECCCCCCEECCCC	37.95	25159151
505	N-linked_Glycosylation	GKVNVVVNFTYQHLS CEEEEEEEEEEHHCC	16.36	UniProtKB CARBOHYD
555	Phosphorylation	SRRPAGDSEEEEDDE CCCCCCCCCCHHCHH	46.09	28450419
732	Phosphorylation	IYDGKDFSLMATSLD EECCCCEEEEEECCC	27.63	26074081
736	Phosphorylation	KDFSLMATSLDEKVV CCEEEEEECCCCCEE	18.83	26074081
737	Phosphorylation	DFSLMATSLDEKVVS CEEEEEECCCCCEEE	25.04	26074081
744	Phosphorylation	SLDEKVVSIHQDPKF CCCCCEEEECCCCCC	19.83	26074081
783	Acetylation	SCQKSKRKSVLAVGT HHHHCCCCCEEEEEC	48.96	25953088
784	Phosphorylation	CQKSKRKSVLAVGTA HHHCCCCCEEEEECE	26.79	-
790	Phosphorylation	KSVLAVGTANIKVKF CCEEEEECEEEEEEE	15.21	-
812	Phosphorylation	NTSDSRHTGAGVHME CCCCCCCCCCCCCCC	27.84	28787133
823	Phosphorylation	VHMENNVSDRRPKKP CCCCCCCCCCCCCCC	27.76	28787133
1000	Phosphorylation	RGMDFEESKYLLSTN CCCCHHHHCEEECCC	21.28	28165663
1032	Phosphorylation	IDGKDQKSEPPTSPT ECCCCCCCCCCCCCC	50.10	-
1039	Phosphorylation	SEPPTSPTSKRKRVK CCCCCCCCCCCCEEE	46.80	-
1040	Phosphorylation	EPPTSPTSKRKRVKF CCCCCCCCCCCEEEE	33.57	-
1064	Phosphorylation	DEYPTRNSIVMSSED CCCCCCCEEEECCHH	17.17	26552605
1068	Phosphorylation	TRNSIVMSSEDDIKW CCCEEEECCHHHHHH	21.49	28188228
1069	Phosphorylation	RNSIVMSSEDDIKWV CCEEEECCHHHHHHH	27.27	26552605

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T132D_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T132D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T132D_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of T132D_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.