SYUB_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYUB_RAT
• UniProt AC: Q63754
• Protein Name: Beta-synuclein
• Gene Name: Sncb
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 137
• Subcellular Localization: Cytoplasm.
• Protein Description: May be involved in neuronal plasticity..
• Protein Sequence: MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTKEGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKKEEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDSPQEEYQEYEPEAKGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MDVFMKGLSMAKE --CCCCHHHHHHHHH	45.28	22902405
27	O-linked_Glycosylation	EKTKQGVTEAAEKTK HHHCCCHHHHHHHHC	27.08	20676215
32	Ubiquitination	GVTEAAEKTKEGVLY CHHHHHHHHCCCEEE	61.24	-
34	Acetylation	TEAAEKTKEGVLYVG HHHHHHHCCCEEEEC	64.64	-
39	Phosphorylation	KTKEGVLYVGSKTKE HHCCCEEEECCCCCC	10.60	28432305
42	Phosphorylation	EGVLYVGSKTKEGVV CCEEEECCCCCCCCH	27.40	28432305
43	Ubiquitination	GVLYVGSKTKEGVVQ CEEEECCCCCCCCHH	58.65	-
45	Acetylation	LYVGSKTKEGVVQGV EEECCCCCCCCHHHH	57.09	22902405
54	Phosphorylation	GVVQGVASVAEKTKE CCHHHHHHHHHHHHH	21.32	28432305
58	Ubiquitination	GVASVAEKTKEQASH HHHHHHHHHHHHHHH	55.98	-
58	Acetylation	GVASVAEKTKEQASH HHHHHHHHHHHHHHH	55.98	22902405
64	Phosphorylation	EKTKEQASHLGGAVF HHHHHHHHHHCCCCC	20.95	25403869
118	Phosphorylation	LMEPEGESYEDSPQE CCCCCCCCCCCCCHH	44.68	22673903
119	Phosphorylation	MEPEGESYEDSPQEE CCCCCCCCCCCCHHH	21.32	22673903
122	Phosphorylation	EGESYEDSPQEEYQE CCCCCCCCCHHHHHH	19.28	22673903
127	Phosphorylation	EDSPQEEYQEYEPEA CCCCHHHHHHHCCCC	13.09	22673903
130	Phosphorylation	PQEEYQEYEPEAKGP CHHHHHHHCCCCCCC	22.66	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
118	S	Phosphorylation	Kinase	GRK5	Q62833	Uniprot
118	S	Phosphorylation	Kinase	CK2	-	Uniprot
118	S	Phosphorylation	Kinase	BARK1	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYUB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYUB_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SYUB_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.