SYUA_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYUA_BOVIN
• UniProt AC: Q3T0G8
• Protein Name: Alpha-synuclein
• Gene Name: SNCA
• Organism: Bos taurus (Bovine).
• Sequence Length: 140
• Subcellular Localization: Cytoplasm, cytosol . Membrane . Nucleus . Cell junction, synapse . Secreted .
• Protein Description: May be involved in the regulation of dopamine release and transport..
• Protein Sequence: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGRTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGEAVVTGVTAVAQKTVEGAGSIAAATGFGKKDHMGKGEEGASQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDVFMKGL -------CCCCHHHH	10.01	-
87	Phosphorylation	KTVEGAGSIAAATGF CCCCCCCHHHHHCCC	14.44	-
125	Phosphorylation	VDPDNEAYEMPSEEG CCCCCCCCCCCCCCC	13.44	-
129	Phosphorylation	NEAYEMPSEEGYQDY CCCCCCCCCCCCCCC	47.14	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
125	Y	Phosphorylation	Kinase	FYN	A0JNB0	Uniprot
129	S	Phosphorylation	Kinase	PLK2	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYUA_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYUA_BOVIN !!

Protein-Protein Interaction

Oops, there are no PPI records of SYUA_BOVIN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.