SYTL4_RAT - dbPTM
SYTL4_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYTL4_RAT
UniProt AC Q8VHQ7
Protein Name Synaptotagmin-like protein 4
Gene Name Sytl4
Organism Rattus norvegicus (Rat).
Sequence Length 672
Subcellular Localization Membrane
Peripheral membrane protein . Cytoplasmic vesicle, secretory vesicle membrane
Peripheral membrane protein . Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles.
Protein Description Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity)..
Protein Sequence MSEILDLSFLSEMERDLILSVLQRDEELRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQEGLGRLISKSNTCVGCNHLVCRECRVLESNGSWRCKVCSKEIELKKATGDWFYDQKVNRFAYRTGSDIIRMSLRRKPAVNKRETVGQSLLQQTQMGDIWPGRRIIQEQQKEQSVLFEVPKLKSGKSALEAESESLDSYTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKEIAPGNQNAVCGDEGDMIFKKNTRKVLRPSEYTKSVIDLRPEDVAQESGILGDRSKSVPGLSVDMEDEEEEEEDIDHLVKLHRQKLARGSMQSGSSMSTIGSMMSLYSEAGDFGNVSVTGKIAFSLKFEQKTQTLVIHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETFRYEISESLLAQRTLQFSVWHHGRFGRNTFLGEAEVHMDSWKLDKKLDHCLPLHGKISTESSPGLPAHKGELVVSLKYIPASKLPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKSGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISSGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLRSSMVKQKLGV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
75PhosphorylationEGLGRLISKSNTCVG
HHHHHHHCCCCCCCC		34.3228432305
77PhosphorylationLGRLISKSNTCVGCN
HHHHHCCCCCCCCCC		30.4928432305
79PhosphorylationRLISKSNTCVGCNHL
HHHCCCCCCCCCCCE		18.6928432305
99PhosphorylationRVLESNGSWRCKVCS
EEEECCCCEEEEECC		18.6528432305
131PhosphorylationVNRFAYRTGSDIIRM
CCCEEHHCCCHHHHH		28.5028432305
133PhosphorylationRFAYRTGSDIIRMSL
CEEHHCCCHHHHHHC		25.6428432305
180PhosphorylationQEQQKEQSVLFEVPK
HHHHHHCCEEEECCC		23.1428432305
193PhosphorylationPKLKSGKSALEAESE
CCCCCCCCHHHHHHH		41.4326437020
199PhosphorylationKSALEAESESLDSYT
CCHHHHHHHCHHHCC		39.2626437020
201PhosphorylationALEAESESLDSYTAD
HHHHHHHCHHHCCCC		46.9126437020
204PhosphorylationAESESLDSYTADSDS
HHHHCHHHCCCCCCC		29.6726437020
205PhosphorylationESESLDSYTADSDST
HHHCHHHCCCCCCCC		12.9628432305
206PhosphorylationSESLDSYTADSDSTS
HHCHHHCCCCCCCCC		28.1328432305
209PhosphorylationLDSYTADSDSTSRRD
HHHCCCCCCCCCCHH		30.8828432305
211PhosphorylationSYTADSDSTSRRDSL
HCCCCCCCCCCHHHC		32.0328432305
212PhosphorylationYTADSDSTSRRDSLD
CCCCCCCCCCHHHCC		31.1028432305
213PhosphorylationTADSDSTSRRDSLDK
CCCCCCCCCHHHCCC		29.3028432305
217PhosphorylationDSTSRRDSLDKSGLF
CCCCCHHHCCCCCCC		36.3326437020
221PhosphorylationRRDSLDKSGLFPEWK
CHHHCCCCCCCHHHH		40.1628432305
231PhosphorylationFPEWKKMSAPKSQVE
CHHHHHCCCCHHHHH		50.7528432305
235PhosphorylationKKMSAPKSQVEKEIA
HHCCCCHHHHHCCCC		38.1028432305
269PhosphorylationTRKVLRPSEYTKSVI
CCCCCCHHHHCCCHH		36.4828432305
274PhosphorylationRPSEYTKSVIDLRPE
CHHHHCCCHHCCCHH		19.2629779826
287PhosphorylationPEDVAQESGILGDRS
HHHHHHHHCCCCCCC		21.0328432305
294PhosphorylationSGILGDRSKSVPGLS
HCCCCCCCCCCCCCC		33.7428432305
296PhosphorylationILGDRSKSVPGLSVD
CCCCCCCCCCCCCCC		34.4928432305
301PhosphorylationSKSVPGLSVDMEDEE
CCCCCCCCCCCCCCH		23.2228432305
337PhosphorylationMQSGSSMSTIGSMMS
CCCCCCHHHHHHHHH		20.8626022182
338PhosphorylationQSGSSMSTIGSMMSL
CCCCCHHHHHHHHHH		22.2526022182
341PhosphorylationSSMSTIGSMMSLYSE
CCHHHHHHHHHHHHC		13.8826022182
344PhosphorylationSTIGSMMSLYSEAGD
HHHHHHHHHHHCCCC		18.6026022182
347PhosphorylationGSMMSLYSEAGDFGN
HHHHHHHHCCCCCCC		26.6826022182
356PhosphorylationAGDFGNVSVTGKIAF
CCCCCCEEECEEEEE		20.2626022182
434PhosphorylationETFRYEISESLLAQR
HHHCHHHCHHHHHHC		14.8128432305
436PhosphorylationFRYEISESLLAQRTL
HCHHHCHHHHHHCCC		23.1528432305
489PhosphorylationHGKISTESSPGLPAH
CCEECCCCCCCCCCC		41.7528432305
490PhosphorylationGKISTESSPGLPAHK
CEECCCCCCCCCCCC		19.4328432305
503PhosphorylationHKGELVVSLKYIPAS
CCCCEEEEEEEEEHH		16.2128432305
521PhosphorylationVGGDRKKSKGGEGGE
CCCCCCCCCCCCCCC		39.3028432305
544PhosphorylationKNLTAAKSGGTSDSF
HCCCCHHCCCCCHHH		37.4228432305
547PhosphorylationTAAKSGGTSDSFVKG
CCHHCCCCCHHHHHH		32.6528432305
548PhosphorylationAAKSGGTSDSFVKGY
CHHCCCCCHHHHHHH		34.2328432305
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYTL4_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYTL4_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYTL4_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SYTL4_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYTL4_RAT

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Related Literatures of Post-Translational Modification

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