SYT5_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT5_RAT
• UniProt AC: P47861
• Protein Name: Synaptotagmin-5
• Gene Name: Syt5
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 386
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein . Recycling endosome membrane ; Single-pass membrane protein . In mast cells, localizes to the endocytic recycling compartment.
• Protein Description: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface..
• Protein Sequence: MFPEPPTPGSPAPETPPDSSRIRQGAVPAWVLATILLGSGLLVFSSCFCLYRKRCRRRMGKKSQAQAQVHLQEVKELGRSYIDKVQPEIEELDPSPSMPGQQVLDKHQLGRLQYSLDYDFQTGQLLVGILQAEGLAALDLGGSSDPYVSVYLLPDKRRRHETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVNLGRPVQAWRELQVAPKEEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGTAVGGAGLRHWADMLANPRRPIAQWHSLRPPDRARPIPAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Ubiquitination	CRRRMGKKSQAQAQV HHHHCCCHHHHHHHH	41.91	-
75	Ubiquitination	QVHLQEVKELGRSYI HHHHHHHHHHHHHHH	46.60	-
95	Phosphorylation	EIEELDPSPSMPGQQ HHHHCCCCCCCCCCE	29.31	28551015
97	Phosphorylation	EELDPSPSMPGQQVL HHCCCCCCCCCCEEC	41.78	28551015
252	Phosphorylation	FSLRYVPTAGKLTVI EEEEECCCCCEEEEE	37.69	25403869
278	Phosphorylation	VGGLSDPYVKVHLLQ CCCCCCCCHHHEEEC	20.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYT5_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYT5_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT5_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SYT5_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.