SYT2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT2_RAT
• UniProt AC: P29101
• Protein Name: Synaptotagmin-2 {ECO:0000305}
• Gene Name: Syt2 {ECO:0000312|RGD:3804}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 422
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Synaptic vesicles and chromaffin granules.
• Protein Description: Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes..
• Protein Sequence: MRNIFKRNQEPIVAPATTTATMPLAPAAPADNSTESTGTGESQEDMFAKLKDKFFNEINKIPLPPWALIAMAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	N-linked_Glycosylation	APAAPADNSTESTGT CCCCCCCCCCCCCCC	53.60	-
106	Ubiquitination	KEKGKGMKNAMNMKD HHCCHHHHHCCCHHH	50.66	-
125	Phosphorylation	QDDDDAETGLTEGEG CCCCHHHCCCCCCCC	38.93	28551015
128	Phosphorylation	DDAETGLTEGEGEGE CHHHCCCCCCCCCCC	43.20	30411139
190	Acetylation	KVFLLPDKKKKYETK EEEECCCCHHCCCCC	65.63	22902405
230	Phosphorylation	KTLVMAIYDFDRFSK EEEEEEEEECCCCCC	10.87	-
286	Phosphorylation	TSLRYVPTAGKLTVC HHCCCCCCCCEEEEE	37.69	27115346
293	S-nitrosocysteine	TAGKLTVCILEAKNL CCCEEEEEEEECCCC	2.18	-
293	S-nitrosylation	TAGKLTVCILEAKNL CCCEEEEEEEECCCC	2.18	22178444
312	Phosphorylation	VGGLSDPYVKIHLMQ CCCCCCCHHHHEEHH	21.26	-
322	Acetylation	IHLMQNGKRLKKKKT HEEHHCCCCCCCCCC	63.21	-
365	Phosphorylation	VVVTVLDYDKLGKNE EEEEECCHHHCCCCC	15.71	-
409	Acetylation	IAQWHSLKPEEEVDA CHHHHCCCCHHHHHH	54.09	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
202	T	Phosphorylation	Kinase	WNK1	Q9JIH7	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYT2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SYT2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.