SYT2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT2_MOUSE
• UniProt AC: P46097
• Protein Name: Synaptotagmin-2 {ECO:0000305}
• Gene Name: Syt2 {ECO:0000312|MGI:MGI:99666}
• Organism: Mus musculus (Mouse).
• Sequence Length: 422
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Synaptic vesicles and chromaffin granules.
• Protein Description: Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. [PubMed: 7961887 May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse]
• Protein Sequence: MRNIFKRNQEPNVAPATTTATMPLAPVAPADNSTESTGPGESQEDMFAKLKEKFFNEINKIPLPPWALIAMAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELAGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	N-linked_Glycosylation	APVAPADNSTESTGP CCCCCCCCCCCCCCC	53.60	-
112	Ubiquitination	MKNAMNMKDMKGGQD HHHCCCHHHCCCCCC	50.06	22790023
125	Phosphorylation	QDDDDAETGLTEGEG CCCCHHHCCCCCCCC	38.93	25521595
128	Phosphorylation	DDAETGLTEGEGEGE CHHHCCCCCCCCCCC	43.20	25521595
202	Phosphorylation	ETKVHRKTLNPAFNE CCCCCCCCCCHHHCC	31.55	15350218
224	Phosphorylation	YQELAGKTLVMAIYD HHHHCCCEEEEEEEC	24.54	25177544
230	Phosphorylation	KTLVMAIYDFDRFSK CEEEEEEECCCCCCC	10.87	25177544
236	Phosphorylation	IYDFDRFSKHDIIGE EECCCCCCCCCEEEE	29.94	29899451
268	Ubiquitination	RDLQGGEKEEPEKLG HHCCCCCCCCHHHHH	71.32	22790023
279	Phosphorylation	EKLGDICTSLRYVPT HHHHHHHHHCCCCCC	31.00	22324799
280	Phosphorylation	KLGDICTSLRYVPTA HHHHHHHHCCCCCCC	13.36	22324799
283	Phosphorylation	DICTSLRYVPTAGKL HHHHHCCCCCCCCEE	18.97	25159016
286	Phosphorylation	TSLRYVPTAGKLTVC HHCCCCCCCCEEEEE	37.69	22324799
289	Ubiquitination	RYVPTAGKLTVCILE CCCCCCCEEEEEEEE	38.22	22790023
293	S-nitrosylation	TAGKLTVCILEAKNL CCCEEEEEEEECCCC	2.18	24895380
298	Ubiquitination	TVCILEAKNLKKMDV EEEEEECCCCCCCCC	54.13	22790023
302	Ubiquitination	LEAKNLKKMDVGGLS EECCCCCCCCCCCCC	43.42	-
309	Phosphorylation	KMDVGGLSDPYVKIH CCCCCCCCCCHHHHE	39.55	20415495
312	Phosphorylation	VGGLSDPYVKIHLMQ CCCCCCCHHHHEEHH	21.26	22817900
314	Ubiquitination	GLSDPYVKIHLMQNG CCCCCHHHHEEHHCC	20.68	-
322	Ubiquitination	IHLMQNGKRLKKKKT HEEHHCCCCCCCCCC	63.21	-
345	Phosphorylation	PYFNESFSFEIPFEQ CCCCCCEEEECCHHH	31.11	-
367	Ubiquitination	VTVLDYDKLGKNEAI EEECCHHHCCCCCCC	53.57	22790023
376	Ubiquitination	GKNEAIGKIFVGSNA CCCCCCEEEEEECCC	27.19	22790023
386	Phosphorylation	VGSNATGTELRHWSD EECCCCCCCHHHHHH	27.73	15350218
407	Phosphorylation	RPIAQWHSLKPEEEV CCCHHHHCCCCHHHH	34.82	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
202	T	Phosphorylation	Kinase	WNK1	P83741	PhosphoELM
202	T	Phosphorylation	Kinase	WNK1	Q9JIH7	PSP
386	T	Phosphorylation	Kinase	WNK1	P83741	PhosphoELM
386	T	Phosphorylation	Kinase	WNK1	Q9JIH7	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYT2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SYT2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.