| UniProt ID | SYT15_HUMAN | |
|---|---|---|
| UniProt AC | Q9BQS2 | |
| Protein Name | Synaptotagmin-15 | |
| Gene Name | SYT15 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 421 | |
| Subcellular Localization |
Isoform 1: Cell membrane Single-pass type III membrane protein. Isoform 2: Cell membrane Single-pass type III membrane protein. Isoform 4: Cell membrane Single-pass type III membrane protein. |
|
| Protein Description | May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.. | |
| Protein Sequence | MAEQLALVIGGTIGGLLLLLLIGASCCLWRRFCATLTYEELPGTPAMATTAASSGQRDRPCQPHARTQLSRPPAVPFVVPPTLQGRDWVPLHSGEWADAPWDPCPASELLPHTSSGGLGDACMVGAINPELYKFPEDKSETDFPDGCLGRLWFSVEYEQEAERLLVGLIKAQHLQAPSETCSPLVKLYLLPDERRFLQSKTKRKTSNPQFDEHFIFQVSSKTITQRVLKFSVYHVDRQRKHQLLGQVLFPLKNETLVGDCRRVIWRDLEAESLEPPSEFGDLQFCLSYNDYLSRLTVVVLRAKGLRLQEDRGIVSVFVKVSLMNHNKFVKCKKTSAVLGSINPVYNETFSFKADATELDTASLSLTVVQNMEGDKSQQLGRVVVGPYMYTRGRELEHWDEMLSKPKELVKRWHALCRTTEP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 178 | Phosphorylation | AQHLQAPSETCSPLV HHHCCCCCCCCCCCH | 48.86 | 29083192 | |
| 180 | Phosphorylation | HLQAPSETCSPLVKL HCCCCCCCCCCCHHH | 23.71 | 29083192 | |
| 182 | Phosphorylation | QAPSETCSPLVKLYL CCCCCCCCCCHHHHC | 28.78 | 24719451 | |
| 188 | Phosphorylation | CSPLVKLYLLPDERR CCCCHHHHCCCHHHH | 10.65 | - | |
| 345 | Phosphorylation | LGSINPVYNETFSFK EECCCCCCCCCEEEE | 14.45 | 22210691 | |
| 350 | Phosphorylation | PVYNETFSFKADATE CCCCCCEEEECCCCC | 33.00 | 24719451 | |
| 364 | Phosphorylation | ELDTASLSLTVVQNM CCCCCEEEEEEEECC | 21.35 | 18187866 | |
| 403 | Phosphorylation | EHWDEMLSKPKELVK HHHHHHHHCHHHHHH | 45.67 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYT15_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SYT15_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYT15_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SYT15_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364, AND MASSSPECTROMETRY. | |
