SYT11_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT11_RAT
• UniProt AC: O08835
• Protein Name: Synaptotagmin-11
• Gene Name: Syt11
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 430
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.
• Protein Description: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis..
• Protein Sequence: MAEITNIRPSFDVSPVAAGLIGASVLVVCVSVTVFVWTCCHQQAEKKHKTPPYKFIHMLKGISIYPETLSNKKKIIKVRRDKDGSHRESGRGNLLVNAESGLLSHDRDPRGPSPASCIDQLPIKRDYGEELRSPMTSLTPGESKPTSPSSPEEDVMLGSLTFSVDYNFPKKALVVTIQEAHGLPVMDGQTQGSDPYIKMTILPDKRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGKVQLTRDIIKRNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGNPYVKVNVYYGRKRIAKKKTHVKKCTLNPIFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNEVVGRLILGAHSVTTSGAEHWREVCESPRKPVAKWHSLSEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Phosphorylation	GISIYPETLSNKKKI CCCCCHHHHCCCCEE	30.86	27097102
70	Phosphorylation	SIYPETLSNKKKIIK CCCHHHHCCCCEEEE	54.76	27097102
72	Ubiquitination	YPETLSNKKKIIKVR CHHHHCCCCEEEEEE	52.66	-
85	Phosphorylation	VRRDKDGSHRESGRG EEECCCCCCCCCCCC	29.51	25403869
100	Phosphorylation	NLLVNAESGLLSHDR CEEEECCCCCCCCCC	32.12	25403869
104	Phosphorylation	NAESGLLSHDRDPRG ECCCCCCCCCCCCCC	28.52	25403869
113	Phosphorylation	DRDPRGPSPASCIDQ CCCCCCCCCCHHHHC	35.60	28432305
116	Phosphorylation	PRGPSPASCIDQLPI CCCCCCCHHHHCCCC	18.26	28432305
124	Ubiquitination	CIDQLPIKRDYGEEL HHHCCCCCCCCCHHH	36.96	-
133	Phosphorylation	DYGEELRSPMTSLTP CCCHHHCCCCCCCCC	31.48	-
416	Phosphorylation	HWREVCESPRKPVAK HHHHHHHCCCCCCCC	25.52	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYT11_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYT11_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT11_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SYT11_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.