| UniProt ID | SYRC_RAT | |
|---|---|---|
| UniProt AC | P40329 | |
| Protein Name | Arginine--tRNA ligase, cytoplasmic | |
| Gene Name | Rars | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 660 | |
| Subcellular Localization | Cytoplasm . Cytoplasm, cytosol . | |
| Protein Description | Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.. | |
| Protein Sequence | MDGLVAQCSARLLQQEKEIKSLTAEIDRLKNCSYLEASPSLEQLREENLKLKYRLNILRRSLQAERKRPTKNMININSRLQELFGCAIKAAYPDLENPPLVVTPSQQPKFGDYQCNSAMGISQMLKAKEQKVSPREIAENITKHLPNNEYIDRVEIAGPGFINVHLRKDFVSEQLTNLLVNGVQLPVLGENEKVIVDFSSPNIAKEMHVGHLRSTIIGESMSRLFEFAGYNVLRLNHVGDWGTQFGMLIAHLQDKFPDYLTVSPPIGDLQAFYKESKKRFDTEEEFKKRAYECVVLLQSKNPDIMKAWNLICDVSREEFNKIYDALDITLIERGESFYQDRMKDIVKEFEDKGFVQVDDGRKIVFVPGCSVPLTIVKSDGGYTYDTSDLAAIKQRLFEEKANKIIYVVDNGQATHFQTVFAAAQMIGWYDPKVTRVAHVGFGVVLGEDKKKFKTRSGETVRLMDLLEEGLRRSMDKLKEKERDKVLTEEELKAAQTSVAYGCIKYADLSHNRLNDYVFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQRAARETKIILDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATTFTEFYDSCYCVEKDRQTGKVLKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDGLVAQC -------CCHHHHHH | 9.23 | - | |
| 17 | Acetylation | ARLLQQEKEIKSLTA HHHHHHHHHHHHHHH | 61.47 | 22902405 | |
| 20 | Acetylation | LQQEKEIKSLTAEID HHHHHHHHHHHHHHH | 40.27 | 22902405 | |
| 38 | Phosphorylation | NCSYLEASPSLEQLR CCCHHHCCCCHHHHH | 12.97 | 27097102 | |
| 40 | Phosphorylation | SYLEASPSLEQLREE CHHHCCCCHHHHHHH | 41.88 | 27097102 | |
| 205 | Acetylation | FSSPNIAKEMHVGHL CCCCCHHHHCCCCHH | 52.34 | 22902405 | |
| 278 | Acetylation | AFYKESKKRFDTEEE HHHHHHHHCCCCHHH | 68.52 | 22902405 | |
| 378 | Phosphorylation | VPLTIVKSDGGYTYD CEEEEEECCCCCEEE | 30.50 | 25575281 | |
| 383 | Phosphorylation | VKSDGGYTYDTSDLA EECCCCCEEEHHHHH | 20.42 | 30181290 | |
| 393 | Acetylation | TSDLAAIKQRLFEEK HHHHHHHHHHHHHHH | 25.33 | 22902405 | |
| 393 | Ubiquitination | TSDLAAIKQRLFEEK HHHHHHHHHHHHHHH | 25.33 | - | |
| 400 | Acetylation | KQRLFEEKANKIIYV HHHHHHHHCCCEEEE | 50.49 | 22902405 | |
| 434 | Phosphorylation | GWYDPKVTRVAHVGF CCCCCCCCEEEEEEE | 26.08 | 21373199 | |
| 536 | Phosphorylation | NTAAYLLYAFTRIRS CHHHHHHHHHHHHHH | 9.32 | - | |
| 570 | Acetylation | KIILDHEKEWKLGRC CEECCCHHHHHHHHH | 66.51 | 22902405 | |
| 573 | Acetylation | LDHEKEWKLGRCILR CCCHHHHHHHHHHHH | 42.00 | 22902405 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYRC_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SYRC_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYRC_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SYRC_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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