SYP1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYP1_SCHPO
• UniProt AC: O43059
• Protein Name: Cytoskeletal protein syp1
• Gene Name: syp1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 818
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Multi-functional protein that contributes to the endocytic process, but also to events that occur at the neck during cytokinesis. Plays a role as an endocytic adapters with membrane-tubulation activity that associates with transmembrane cargo proteins and initiates the formation of endocytic sites. Contributes to the stabilization of the nascent clathrin-coated pit. Plays also a role in late endocytosis by mediating vesiculation. Involved in the regulation of cell cycle-dependent dynamics of the septin cytoskeleton by promoting septin turnover in different cell cycle stages (By similarity)..
• Protein Sequence: MESLTKTEYVDAFLSNYSPNDSMSIFRQRLEQVRLDNDMLSQWIRERMDIERQYSDQLHKLAMNMQEKNNSSFAFNYAWKQLEGETLEISRYHSQIIGQIASQVYKPLIDYYTSSPQTATLRRLAERLSTVAEEMASSSVPGLKGLKKKGRDADTKSQNDLTASRATWDSDAPLAFEKLQIVDEERLLILKQVYLTIASLETDTALKQQEFFSKSMAVYSDLPIEGEIRQFMNSTSKVMSSASANKPSKSSGFHINNGKSKEEKSHGENESGGKLKNKMSTLFRRKTIMPKKDKKPSHKSNGRPNKLTAFFNKNSKASSISSAEEHPSNIDDSSIERRHYDSNHSSQIRDHPSTNNNASSYQNFNETSDEGEDNDATIRANNVRSSFLEAPLPVQPNVQAETVTPKISSKASPFNKPNSVHSEASRNTPSSIDRENASHSNPIMMHGNDFGGNFNNMQSRSTTTSPTSAVASPAPTENEDSNAAIERVANTLRKNPTISRRTRRAGTMDRYATASSDYMESNLGSLPNLSTLSLQSGPDSTATWHPEFPNSSGLSASIVEKYSGELSEDGLLHPSCSGHIFMKYTSDFNTPPPEMGVRVASEFPMSFTHLNDHAVKYGPSENTLSLIPELLLSPIKVTDFNLHLDSINGASCIPLTVVQKWKHDESSSSMIAFVKPNPVWRNLGSSLHIEKLVIIVYLGENVLVKSCQSSPAGEFSRKTSKLKLHLSNINISSSGFKILAKFAISPSAAIRKPVIEFRIRMVDSSNNPGLTKLFLKPDMFDTTSSSGGSQLESAYEETKVPTSYGIHVRECSVFADMS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	Phosphorylation	NMQEKNNSSFAFNYA HHHHHCCCCHHHHHH	35.91	24763107
72	Phosphorylation	MQEKNNSSFAFNYAW HHHHCCCCHHHHHHH	23.79	25720772
155	Phosphorylation	KKGRDADTKSQNDLT HCCCCCCCCCHHHCC	34.02	29996109
157	Phosphorylation	GRDADTKSQNDLTAS CCCCCCCCHHHCCHH	35.99	24763107
236	Phosphorylation	RQFMNSTSKVMSSAS HHHHHCHHHHHHHHC	24.07	28889911
250	Phosphorylation	SANKPSKSSGFHINN CCCCCCCCCCCCCCC	39.78	24763107
251	Phosphorylation	ANKPSKSSGFHINNG CCCCCCCCCCCCCCC	49.57	29996109
318	Phosphorylation	FNKNSKASSISSAEE ECCCCCCCCCCCCCC	31.76	28889911
319	Phosphorylation	NKNSKASSISSAEEH CCCCCCCCCCCCCCC	31.20	25720772
321	Phosphorylation	NSKASSISSAEEHPS CCCCCCCCCCCCCCC	25.99	29996109
322	Phosphorylation	SKASSISSAEEHPSN CCCCCCCCCCCCCCC	37.72	28889911
328	Phosphorylation	SSAEEHPSNIDDSSI CCCCCCCCCCCCHHH	48.61	25720772
333	Phosphorylation	HPSNIDDSSIERRHY CCCCCCCHHHHHHCC	29.48	28889911
334	Phosphorylation	PSNIDDSSIERRHYD CCCCCCHHHHHHCCC	35.15	28889911
340	Phosphorylation	SSIERRHYDSNHSSQ HHHHHHCCCCCCCHH	21.18	29996109
342	Phosphorylation	IERRHYDSNHSSQIR HHHHCCCCCCCHHCC	29.31	29996109
345	Phosphorylation	RHYDSNHSSQIRDHP HCCCCCCCHHCCCCC	28.34	29996109
367	Phosphorylation	SYQNFNETSDEGEDN HCCCCCCCCCCCCCC	42.45	25720772
368	Phosphorylation	YQNFNETSDEGEDND CCCCCCCCCCCCCCC	27.73	25720772
385	Phosphorylation	IRANNVRSSFLEAPL HEECCCCCCHHCCCC	22.59	29996109
386	Phosphorylation	RANNVRSSFLEAPLP EECCCCCCHHCCCCC	24.24	29996109
412	Phosphorylation	PKISSKASPFNKPNS CCCCCCCCCCCCCCC	33.49	28889911
419	Phosphorylation	SPFNKPNSVHSEASR CCCCCCCCCCCHHHC	29.72	28889911
422	Phosphorylation	NKPNSVHSEASRNTP CCCCCCCCHHHCCCC	32.47	29996109
425	Phosphorylation	NSVHSEASRNTPSSI CCCCCHHHCCCCCCC	23.24	25720772
461	Phosphorylation	FNNMQSRSTTTSPTS CCCCCCCCCCCCCCC	35.04	25720772
462	Phosphorylation	NNMQSRSTTTSPTSA CCCCCCCCCCCCCCC	32.74	28889911
463	Phosphorylation	NMQSRSTTTSPTSAV CCCCCCCCCCCCCCC	26.90	28889911
464	Phosphorylation	MQSRSTTTSPTSAVA CCCCCCCCCCCCCCC	32.56	25720772
465	Phosphorylation	QSRSTTTSPTSAVAS CCCCCCCCCCCCCCC	24.88	25720772
467	Phosphorylation	RSTTTSPTSAVASPA CCCCCCCCCCCCCCC	29.14	29996109
468	Phosphorylation	STTTSPTSAVASPAP CCCCCCCCCCCCCCC	24.91	29996109
472	Phosphorylation	SPTSAVASPAPTENE CCCCCCCCCCCCCCC	18.26	28889911
783	Phosphorylation	KPDMFDTTSSSGGSQ CCCCCCCCCCCCCCH	28.58	21712547
784	Phosphorylation	PDMFDTTSSSGGSQL CCCCCCCCCCCCCHH	25.30	21712547
785	Phosphorylation	DMFDTTSSSGGSQLE CCCCCCCCCCCCHHH	30.80	21712547
786	Phosphorylation	MFDTTSSSGGSQLES CCCCCCCCCCCHHHH	47.11	21712547
789	Phosphorylation	TTSSSGGSQLESAYE CCCCCCCCHHHHHHH	34.81	24763107
793	Phosphorylation	SGGSQLESAYEETKV CCCCHHHHHHHHCCC	44.75	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYP1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYP1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYP1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YHLA_SCHPO	SPBC800.10c	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-463, AND MASSSPECTROMETRY.
PubMed: 18257517