SYNRG_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYNRG_RAT
• UniProt AC: Q9JKC9
• Protein Name: Synergin gamma
• Gene Name: Synrg
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1329
• Subcellular Localization: Cytoplasm . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Associates with membranes via the adapter protein complex AP-1. Colocalizes with AP1G1.
• Protein Description: May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins..
• Protein Sequence: MALRPGAGASGAAGAGTGPGGAGSFMFPVAGGMRPPQGLIPMQQQGFPMVSVMQPNMQGMMGMNYSSQMSQGPIAMQAGIPMGPMPAAGVPFLGQPPFLGMRPAAPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKNRDDALEAIKGNLDGFSRDAKMHPTPASHPKKPDCPTSSHSTKTVSPSSAFLGEDEFSGFMQGPVELPTCGPSSTAQPFQSFLPSTPLGQLHTQKAGAQPLPPGQAPVSFAVHGVHGQIPCLSAASASHSMQKAGPSLEEKLLVSCDISASGQEHIKLSSPEAGHRAVVPGSSKNSPGLMAHNGGAVDGCVSGPTTAVAEKTSDQNLSKEESGVGVFPSQDPVQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPGKLTKEELYTVLAMVAVTQRGVPAMSPDTLNQFPAAPIPTLSGFPMTLPTPVSQPTAMTSGPAGSIPLSLGQPIMGINLVGPVGGAAAPTSSGFMPAYPSNQVGKTEEDDFQDFQDASKSGSIDDSFTDFQEVPASSKTSNSQHGNSAPSLLIPLPGTKASTDKYAVFKGISAEKPSENPASFGESGDKYSAFRELEPTADSKPLGESFAEFRSTGTDDGFTDFKTADSVSPLEPPTKDSFPSAFASGAAQQTQTQVKTPLNLADLDMFSSVDCSGEKPVPFSAAFSTSKSVSSRPQPAGSAAAPASLASTKASSLADDFGEFNLFGEYSNPASVGEQDDFADFMAFGNSSIPSEPKADDKYEALREEGSPGALSTSTVEGAHNPPVSSSKYDVFKQLSLEGAGLAIEEFKENTPSTKSDGDFADFHSSKFSSTSSDKSLGEKAVAFRHAKEDSASVKSLDLPSIGGSSVGKEDSEDALSVQFDMKLADVGGDLKHVMSDSSLDLPTVSGQHPPAAGSALASEDALPETPFPAFASFKDMMPQTTEQKEYESGDFQDFTRQDMPMVDRSQENTCPSPASSVASHETPKEGADDFGEFQSEKPKISKFDFLVANSQSKMKSSEEMIKSELATFDLSVQGSHKRSLSLGDKEISRSSPSPALEQPFRDRSNTLSERAALPVIRDKYKDLTGEVEENERYAYEWQRCLGSALDVIKKANDTLNGISSSAVCTEVIQSAQGMEYLLGVVEVYRVTKRVELGIKATAVCSEKLQQLLKDIDKVWNNLIGFMSLTTLTPDENSLDFSSCMLRPGIKNAQELACGVCLLNVDSRSRKEETPAEEQPKKAFNSETDSFKLAYGGHQYHASCANFWINCVEPKPPGLLLPDLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
311	Phosphorylation	VSCDISASGQEHIKL EEEEECCCCCCCEEC	33.93	25575281
319	Phosphorylation	GQEHIKLSSPEAGHR CCCCEECCCCCCCCC	38.55	25575281
320	Phosphorylation	QEHIKLSSPEAGHRA CCCEECCCCCCCCCE	36.88	25575281
336	Phosphorylation	VPGSSKNSPGLMAHN CCCCCCCCCCCCCCC	24.87	30181290
565	Phosphorylation	DFQDASKSGSIDDSF HHHHHHHCCCCCCCC	34.97	28432305
567	Phosphorylation	QDASKSGSIDDSFTD HHHHHCCCCCCCCCC	29.90	25403869
571	Phosphorylation	KSGSIDDSFTDFQEV HCCCCCCCCCCCCCC	26.71	28432305
573	Phosphorylation	GSIDDSFTDFQEVPA CCCCCCCCCCCCCCC	39.60	28551015
584	Phosphorylation	EVPASSKTSNSQHGN CCCCCCCCCCCCCCC	34.78	25575281
585	Phosphorylation	VPASSKTSNSQHGNS CCCCCCCCCCCCCCC	37.92	25575281
587	Phosphorylation	ASSKTSNSQHGNSAP CCCCCCCCCCCCCCC	24.26	25575281
592	Phosphorylation	SNSQHGNSAPSLLIP CCCCCCCCCCCEEEE	46.26	25575281
595	Phosphorylation	QHGNSAPSLLIPLPG CCCCCCCCEEEECCC	35.21	25575281
609	Acetylation	GTKASTDKYAVFKGI CCCCCCCCEEEEECC	34.89	22902405
662	Phosphorylation	AEFRSTGTDDGFTDF HHHHCCCCCCCCCCC	30.88	28432305
671	Phosphorylation	DGFTDFKTADSVSPL CCCCCCCCCCCCCCC	35.37	28689409
674	Phosphorylation	TDFKTADSVSPLEPP CCCCCCCCCCCCCCC	23.25	23984901
676	Phosphorylation	FKTADSVSPLEPPTK CCCCCCCCCCCCCCC	27.93	27097102
807	Phosphorylation	EPKADDKYEALREEG CCCCCHHHHHHHHHC	17.27	27097102
815	Phosphorylation	EALREEGSPGALSTS HHHHHHCCCCCCCCC	24.36	27097102
820	Phosphorylation	EGSPGALSTSTVEGA HCCCCCCCCCCCCCC	21.56	27097102
821	Phosphorylation	GSPGALSTSTVEGAH CCCCCCCCCCCCCCC	29.30	27097102
822	Phosphorylation	SPGALSTSTVEGAHN CCCCCCCCCCCCCCC	27.38	27097102
823	Phosphorylation	PGALSTSTVEGAHNP CCCCCCCCCCCCCCC	23.75	27097102
833	Phosphorylation	GAHNPPVSSSKYDVF CCCCCCCCHHHHCHH	34.37	30181290
834	Phosphorylation	AHNPPVSSSKYDVFK CCCCCCCHHHHCHHH	30.96	30181290
835	Phosphorylation	HNPPVSSSKYDVFKQ CCCCCCHHHHCHHHH	27.94	30181290
836	Acetylation	NPPVSSSKYDVFKQL CCCCCHHHHCHHHHH	47.63	-
844	Phosphorylation	YDVFKQLSLEGAGLA HCHHHHHCCCCCCEE	23.14	27097102
864	Phosphorylation	ENTPSTKSDGDFADF HCCCCCCCCCCHHHH	47.08	30181290
877	Phosphorylation	DFHSSKFSSTSSDKS HHCCCCCCCCCCCCC	36.12	25575281
878	Phosphorylation	FHSSKFSSTSSDKSL HCCCCCCCCCCCCCH	35.13	28432305
879	Phosphorylation	HSSKFSSTSSDKSLG CCCCCCCCCCCCCHH	30.93	28432305
880	Phosphorylation	SSKFSSTSSDKSLGE CCCCCCCCCCCCHHH	38.19	28432305
881	Phosphorylation	SKFSSTSSDKSLGEK CCCCCCCCCCCHHHH	49.50	28432305
884	Phosphorylation	SSTSSDKSLGEKAVA CCCCCCCCHHHHHHH	46.74	28432305
899	Phosphorylation	FRHAKEDSASVKSLD HHHCCCCCCCCEECC	24.43	28432305
901	Phosphorylation	HAKEDSASVKSLDLP HCCCCCCCCEECCCC	33.75	28432305
904	Phosphorylation	EDSASVKSLDLPSIG CCCCCCEECCCCCCC	25.59	29779826
909	Phosphorylation	VKSLDLPSIGGSSVG CEECCCCCCCCCCCC	40.96	30181290
913	Phosphorylation	DLPSIGGSSVGKEDS CCCCCCCCCCCCCCC	19.35	30181290
914	Phosphorylation	LPSIGGSSVGKEDSE CCCCCCCCCCCCCCC	37.86	30181290
944	Phosphorylation	GDLKHVMSDSSLDLP CCCHHHCCCCCCCCC	33.00	28432305
946	Phosphorylation	LKHVMSDSSLDLPTV CHHHCCCCCCCCCCC	26.03	28432305
947	Phosphorylation	KHVMSDSSLDLPTVS HHHCCCCCCCCCCCC	30.78	28432305
952	Phosphorylation	DSSLDLPTVSGQHPP CCCCCCCCCCCCCCC	34.30	28432305
954	Phosphorylation	SLDLPTVSGQHPPAA CCCCCCCCCCCCCCC	34.90	28432305
963	Phosphorylation	QHPPAAGSALASEDA CCCCCCCCCCCCCCC	18.51	27097102
967	Phosphorylation	AAGSALASEDALPET CCCCCCCCCCCCCCC	36.54	27097102
974	Phosphorylation	SEDALPETPFPAFAS CCCCCCCCCCCCCCC	28.43	25575281
995	Phosphorylation	QTTEQKEYESGDFQD CCCCCHHHCCCCCCC	23.56	28689409
997	Phosphorylation	TEQKEYESGDFQDFT CCCHHHCCCCCCCCC	42.64	28432305
1004	Phosphorylation	SGDFQDFTRQDMPMV CCCCCCCCCCCCCCC	35.39	28689409
1014	Phosphorylation	DMPMVDRSQENTCPS CCCCCCCCCCCCCCC	37.06	25575281
1018	Phosphorylation	VDRSQENTCPSPASS CCCCCCCCCCCCCHH	25.66	28689409
1021	Phosphorylation	SQENTCPSPASSVAS CCCCCCCCCCHHHCC	34.93	27097102
1024	Phosphorylation	NTCPSPASSVASHET CCCCCCCHHHCCCCC	28.82	27097102
1025	Phosphorylation	TCPSPASSVASHETP CCCCCCHHHCCCCCC	24.65	27097102
1028	Phosphorylation	SPASSVASHETPKEG CCCHHHCCCCCCCCC	21.50	27097102
1031	Phosphorylation	SSVASHETPKEGADD HHHCCCCCCCCCCCC	33.95	27097102
1044	Phosphorylation	DDFGEFQSEKPKISK CCCCCCCCCCCCCCH	53.56	25575281
1088	Phosphorylation	VQGSHKRSLSLGDKE CCCCCCCCCCCCCCC	27.41	25403869
1090	Phosphorylation	GSHKRSLSLGDKEIS CCCCCCCCCCCCCCC	31.39	29779826
1099	Phosphorylation	GDKEISRSSPSPALE CCCCCCCCCCCHHHC	39.55	28432305
1100	Phosphorylation	DKEISRSSPSPALEQ CCCCCCCCCCHHHCC	28.43	28432305
1102	Phosphorylation	EISRSSPSPALEQPF CCCCCCCCHHHCCCC	25.42	28432305
1113	Phosphorylation	EQPFRDRSNTLSERA CCCCCCCCCCHHHHH	38.16	-
1115	Phosphorylation	PFRDRSNTLSERAAL CCCCCCCCHHHHHHH	32.67	-
1290	Phosphorylation	QPKKAFNSETDSFKL CCCHHHCCCCCCEEE	35.11	22673903
1292	Phosphorylation	KKAFNSETDSFKLAY CHHHCCCCCCEEECC	36.44	22673903
1294	Phosphorylation	AFNSETDSFKLAYGG HHCCCCCCEEECCCC	31.53	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYNRG_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYNRG_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYNRG_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SYNRG_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.