SYNPO_RAT - dbPTM
SYNPO_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYNPO_RAT
UniProt AC Q9Z327
Protein Name Synaptopodin
Gene Name Synpo
Organism Rattus norvegicus (Rat).
Sequence Length 931
Subcellular Localization Cytoplasm, cytoskeleton . Cell junction, tight junction . Perikaryon. Cell projection, dendritic spine . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell junction, synapse . Localized at the tight junction of cells. In
Protein Description Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity..
Protein Sequence MLGTHFPPPPLGPSEGRAAPCTFQIPDGSYRCLALEAEESSSEDGLQGEVRLVDLEEEGTSKSRVNHGTPPLSRAPAIIQPSSCCREARGGFQHSDKPSREWDVVQARKVMTASVSSSPVPRVAQKPALGRSTSFTEKDLKEAKERSQRIAAQLTTPPSSNSRGVQLFNRRRQRVNEFTLESRGQRSPKLSQEALQTGHPSSPIGHAPGLSVNPTSPSKPGSPKHSSSQSPSRGVPGHIMEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNRETQQSSPNPPETEEVPSPAADINQNPSSPNATLTTAASNSHHNQPTADVNQNPPATITPVQQNSSETQCSPNGTLDSKPNTPSADDGQRPVPAEEVRSSILLIDKVSAPPSAASPFSREATPLSSSGPPAADLMSSSLLIGMQPSTLVASAEQEVSGHAAVTTPTKVYSEVHLTLAKPASVVNRTARPFGMQSPGTTSQIEQSPMMGRRHFGEKAWAPPASSMADRSPQPQRHIMARSPMVERRLVGQRSPVVERRPLGNFTPPPTYAETLSTAPVASQVRSPPSYSTLYPSSDPKPPHLKGQVVPANKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGMEDEPFALGAEASNFQQEPIARDRSGPAAAEETVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSGHAELARCPSPTMSLPSSWKYTTNAPGGFRVASLSPARTPPASLYHGYLPENGVLRPEPTKQQPHQMRPSLYALSPVKEPAKISSRATSSRASSRTVSPRAASPAKPSSLDLVPNLPRAGLPPSPALPRPSRSSPGLYNAPVQDSLQPTAVSPTYSSDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQVWKPSFCFK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
69PhosphorylationKSRVNHGTPPLSRAP
CCCCCCCCCCCCCCC		17.7429779826
73PhosphorylationNHGTPPLSRAPAIIQ
CCCCCCCCCCCCEEC		31.9725575281
116PhosphorylationKVMTASVSSSPVPRV
EEEEEECCCCCCCCH		23.7028689409
117PhosphorylationVMTASVSSSPVPRVA
EEEEECCCCCCCCHH		36.1828689409
118PhosphorylationMTASVSSSPVPRVAQ
EEEECCCCCCCCHHC		23.5528689409
132PhosphorylationQKPALGRSTSFTEKD
CCCCCCCCCCCCHHH		26.9722673903
133PhosphorylationKPALGRSTSFTEKDL
CCCCCCCCCCCHHHH		26.8822673903
134PhosphorylationPALGRSTSFTEKDLK
CCCCCCCCCCHHHHH		31.2721630457
136PhosphorylationLGRSTSFTEKDLKEA
CCCCCCCCHHHHHHH		41.7222673903
191PhosphorylationGQRSPKLSQEALQTG
CCCCCCCCHHHHHHC		31.9121630457
197PhosphorylationLSQEALQTGHPSSPI
CCHHHHHHCCCCCCC		38.0022673903
201PhosphorylationALQTGHPSSPIGHAP
HHHHCCCCCCCCCCC		42.9722673903
202PhosphorylationLQTGHPSSPIGHAPG
HHHCCCCCCCCCCCC		25.6121630457
211PhosphorylationIGHAPGLSVNPTSPS
CCCCCCCCCCCCCCC		26.2621630457
215PhosphorylationPGLSVNPTSPSKPGS
CCCCCCCCCCCCCCC		48.3322668510
216PhosphorylationGLSVNPTSPSKPGSP
CCCCCCCCCCCCCCC		28.5622673903
218PhosphorylationSVNPTSPSKPGSPKH
CCCCCCCCCCCCCCC		51.7721630457
222PhosphorylationTSPSKPGSPKHSSSQ
CCCCCCCCCCCCCCC		39.0221630457
258PhosphorylationRHLEKVASEEEEVPL
HHHHHHCCCCCCCCE		48.8323712012
385PhosphorylationVPAEEVRSSILLIDK
CCHHHHHHHEEEEEC		27.2330181290
386PhosphorylationPAEEVRSSILLIDKV
CHHHHHHHEEEEECC		13.4930181290
392UbiquitinationSSILLIDKVSAPPSA
HHEEEEECCCCCCCC		30.97-
398PhosphorylationDKVSAPPSAASPFSR
ECCCCCCCCCCCCCC		35.0925575281
401PhosphorylationSAPPSAASPFSREAT
CCCCCCCCCCCCCCC		26.6228689409
404PhosphorylationPSAASPFSREATPLS
CCCCCCCCCCCCCCC		32.3725575281
452PhosphorylationHAAVTTPTKVYSEVH
CCEECCCCEEEEEEE		30.9322668510
464UbiquitinationEVHLTLAKPASVVNR
EEEEEECCCHHHCCC		44.20-
472PhosphorylationPASVVNRTARPFGMQ
CHHHCCCCCCCCCCC		23.0928689409
480PhosphorylationARPFGMQSPGTTSQI
CCCCCCCCCCCCCHH		19.1928689409
483PhosphorylationFGMQSPGTTSQIEQS
CCCCCCCCCCHHHCC		27.0224945867
484PhosphorylationGMQSPGTTSQIEQSP
CCCCCCCCCHHHCCC		25.2524945867
485PhosphorylationMQSPGTTSQIEQSPM
CCCCCCCCHHHCCCC		29.0628689409
490PhosphorylationTTSQIEQSPMMGRRH
CCCHHHCCCCCCCCC		11.2824945867
501UbiquitinationGRRHFGEKAWAPPAS
CCCCCCCCCCCCCCH		50.00-
508PhosphorylationKAWAPPASSMADRSP
CCCCCCCHHHCCCCC		26.8127775022
509PhosphorylationAWAPPASSMADRSPQ
CCCCCCHHHCCCCCC		21.7927775022
514PhosphorylationASSMADRSPQPQRHI
CHHHCCCCCCCCHHH		28.5629779826
525PhosphorylationQRHIMARSPMVERRL
CHHHHHCCHHHHHHC		14.0721630457
537PhosphorylationRRLVGQRSPVVERRP
HHCCCCCCCCCCCCC		17.7329779826
549PhosphorylationRRPLGNFTPPPTYAE
CCCCCCCCCCCCHHH		38.6025403869
553PhosphorylationGNFTPPPTYAETLST
CCCCCCCCHHHHHCC		40.9325403869
554PhosphorylationNFTPPPTYAETLSTA
CCCCCCCHHHHHCCC		14.2825403869
557PhosphorylationPPPTYAETLSTAPVA
CCCCHHHHHCCCCCH		20.1725403869
559PhosphorylationPTYAETLSTAPVASQ
CCHHHHHCCCCCHHH		29.9125575281
560PhosphorylationTYAETLSTAPVASQV
CHHHHHCCCCCHHHC		37.7925575281
565PhosphorylationLSTAPVASQVRSPPS
HCCCCCHHHCCCCCC		29.4628689409
565 (in isoform 2)Phosphorylation-29.46-
569PhosphorylationPVASQVRSPPSYSTL
CCHHHCCCCCCCCCC		42.1625403869
572PhosphorylationSQVRSPPSYSTLYPS
HHCCCCCCCCCCCCC		34.7925575281
583UbiquitinationLYPSSDPKPPHLKGQ
CCCCCCCCCCCCCCC		75.95-
596UbiquitinationGQVVPANKTGILEES
CCEECCCCCCHHHHH		50.68-
611AcetylationMARRGSRKSMFTFVE
HHHHCCCCCCEEECC		48.2222902405
612PhosphorylationARRGSRKSMFTFVEK
HHHCCCCCCEEECCC		20.3025403869
619AcetylationSMFTFVEKPKVTPNP
CCEEECCCCCCCCCC		44.8522902405
638UbiquitinationLVQTADEKRRQRDQG
HHHHHHHHHHHHHCC		54.12-
687PhosphorylationETVPEWASCLKSPRI
HCCHHHHHHHCCCCC		22.5122668510
691PhosphorylationEWASCLKSPRIQAKP
HHHHHHCCCCCCCCC		13.3821630457
697UbiquitinationKSPRIQAKPKPKPNQ
CCCCCCCCCCCCCCC		36.88-
726UbiquitinationRRQSRMEKYVIESSG
HHHHHHHHHHHHCCC		35.16-
742PhosphorylationAELARCPSPTMSLPS
HHHCCCCCCCCCCCC		36.3127097102
744PhosphorylationLARCPSPTMSLPSSW
HCCCCCCCCCCCCCC		24.5927097102
746PhosphorylationRCPSPTMSLPSSWKY
CCCCCCCCCCCCCEE		39.3427097102
749PhosphorylationSPTMSLPSSWKYTTN
CCCCCCCCCCEEECC		54.8723984901
750PhosphorylationPTMSLPSSWKYTTNA
CCCCCCCCCEEECCC		26.1623984901
759 (in isoform 2)Phosphorylation-45.52-
765PhosphorylationPGGFRVASLSPARTP
CCCEEEEECCCCCCC		26.9025403869
767PhosphorylationGFRVASLSPARTPPA
CEEEEECCCCCCCCH		17.6425403869
771PhosphorylationASLSPARTPPASLYH
EECCCCCCCCHHHCC		35.4121630457
775PhosphorylationPARTPPASLYHGYLP
CCCCCCHHHCCCCCC		34.9221630457
777PhosphorylationRTPPASLYHGYLPEN
CCCCHHHCCCCCCCC		7.2421630457
777 (in isoform 2)Phosphorylation-7.24-
780PhosphorylationPASLYHGYLPENGVL
CHHHCCCCCCCCCCC		13.0322673903
791 (in isoform 2)Phosphorylation-47.80-
795 (in isoform 2)Phosphorylation-38.71-
804PhosphorylationHQMRPSLYALSPVKE
CCCCCHHEECCCCCC		15.16-
807PhosphorylationRPSLYALSPVKEPAK
CCHHEECCCCCCCCC		21.3425403869
830PhosphorylationRASSRTVSPRAASPA
CCCCCCCCCCCCCCC		14.1922668510
835PhosphorylationTVSPRAASPAKPSSL
CCCCCCCCCCCCCHH		25.1423712012
838UbiquitinationPRAASPAKPSSLDLV
CCCCCCCCCCHHCCC		49.14-
840PhosphorylationAASPAKPSSLDLVPN
CCCCCCCCHHCCCCC		42.7127097102
841PhosphorylationASPAKPSSLDLVPNL
CCCCCCCHHCCCCCC		34.1427097102
850MethylationDLVPNLPRAGLPPSP
CCCCCCCCCCCCCCC		44.44-
856PhosphorylationPRAGLPPSPALPRPS
CCCCCCCCCCCCCCC		22.3629779826
859 (in isoform 2)Phosphorylation-4.14-
861 (in isoform 2)Phosphorylation-42.55-
863PhosphorylationSPALPRPSRSSPGLY
CCCCCCCCCCCCCCC		46.1828689409
865PhosphorylationALPRPSRSSPGLYNA
CCCCCCCCCCCCCCC		45.2624945867
866PhosphorylationLPRPSRSSPGLYNAP
CCCCCCCCCCCCCCC		23.1324945867
870PhosphorylationSRSSPGLYNAPVQDS
CCCCCCCCCCCCCCC		18.3924945867
877PhosphorylationYNAPVQDSLQPTAVS
CCCCCCCCCCCCCCC		16.2924945867
881PhosphorylationVQDSLQPTAVSPTYS
CCCCCCCCCCCCCCC		27.0824945867
884PhosphorylationSLQPTAVSPTYSSDI
CCCCCCCCCCCCCCC		14.7324945867
886PhosphorylationQPTAVSPTYSSDISP
CCCCCCCCCCCCCCC		28.6424945867
887PhosphorylationPTAVSPTYSSDISPV
CCCCCCCCCCCCCCC		15.0124945867
888PhosphorylationTAVSPTYSSDISPVS
CCCCCCCCCCCCCCC		24.8222673903
889PhosphorylationAVSPTYSSDISPVSP
CCCCCCCCCCCCCCH		28.6624945867
892PhosphorylationPTYSSDISPVSPSRA
CCCCCCCCCCCHHHC		25.0024945867
895PhosphorylationSSDISPVSPSRAWSP
CCCCCCCCHHHCCCC		22.1228689409
897PhosphorylationDISPVSPSRAWSPRA
CCCCCCHHHCCCCCH		27.4221630457
906 (in isoform 2)Phosphorylation-56.46-
911PhosphorylationAKQAPRPSFSTRNAG
HHCCCCCCCCCCCCC		32.8628689409
914PhosphorylationAPRPSFSTRNAGIEA
CCCCCCCCCCCCCCE		26.4028689409
973 (in isoform 2)Phosphorylation--
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYNPO_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYNPO_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYNPO_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SYNPO_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYNPO_RAT

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Related Literatures of Post-Translational Modification

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