dbPTM

SYN2_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYN2_RAT
UniProt AC	Q63537
Protein Name	Synapsin-2
Gene Name	Syn2
Organism	Rattus norvegicus (Rat).
Sequence Length	586
Subcellular Localization	Cell junction, synapse.
Protein Description	Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity)..
Protein Sequence	MMNFLRRRLSDSSFIANLPNGYMTDLQRPEPQQPPPAPGPGTATASAATSAASPGPERRPPPAQAPAPQPAPQPAPTPSVGSSFFSSLSQAVKQTAASAGLVDAPAPSAASRKAKVLLVVDEPHTDWAKCFRGKKILGDYDIKVEQAEFSELNLVAHADGTYAVDMQVLRNGTKVVRSFRPDFVLIRQHAFGMAENEDFRHLVIGMQYAGLPSINSLESIYNFCDKPWVFAQMVAIFKTLGGEKFPLIEQTYYPNHREMLTLPTFPVVVKIGHAHSGMGKVKVENHYDFQDIASVVALTQTYATAEPFIDAKYDIRVQKIGNNYKAYMRTSISGNWKTNTGSAMLEQIAMSDRYKLWVDACSEMFGGLDICAVKAVHGKDGKDYIFEVMDCSMPLIGEHQVEDRQLITDLVISKMNQLLSRTPALSPQRPLTTQQPQSGTLKEPDSSKTPPQRPAPQGGPGQPQGMQPPGKVLPPRRLPSGPSLPPSSSSSSSSSSSSSAPQRPGGPTSTQVNASSSSNSLAEPQAPQAAPPQKPQPHPQLNKSQSLTNAFSFSESSFFRSSANEDEAKAETIRSLRKSFASLFSD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	NFLRRRLSDSSFIAN CHHHHHCCCCCHHHC	33.37	20035839
108	Phosphorylation	LVDAPAPSAASRKAK CCCCCCCCHHHCCCE	38.28	25403869
111	Phosphorylation	APAPSAASRKAKVLL CCCCCHHHCCCEEEE	33.75	25403869
129	Acetylation	EPHTDWAKCFRGKKI CCCCCHHHHHCCCCC	29.65	22902405
129	Ubiquitination	EPHTDWAKCFRGKKI CCCCCHHHHHCCCCC	29.65	-
135	Ubiquitination	AKCFRGKKILGDYDI HHHHCCCCCCCCCCE	46.09	-
140	Phosphorylation	GKKILGDYDIKVEQA CCCCCCCCCEEEEEE	20.12	22673903
244	Acetylation	FKTLGGEKFPLIEQT HHHHCCCCCCCEEEE	56.40	22902405
276	Phosphorylation	VKIGHAHSGMGKVKV EEECCCCCCCCEEEE	31.12	25403869
287	Phosphorylation	KVKVENHYDFQDIAS EEEEECCCCHHHHHH	29.99	-
338	Phosphorylation	SISGNWKTNTGSAML ECCCCCCCCCCHHHH	29.63	28551015
340	Phosphorylation	SGNWKTNTGSAMLEQ CCCCCCCCCHHHHHH	37.43	28551015
342	Phosphorylation	NWKTNTGSAMLEQIA CCCCCCCHHHHHHHH	14.41	25403869
408	Phosphorylation	VEDRQLITDLVISKM CCCHHHHHHHHHHHH	31.69	22673903
413	Phosphorylation	LITDLVISKMNQLLS HHHHHHHHHHHHHHH	20.55	22673903
420	Phosphorylation	SKMNQLLSRTPALSP HHHHHHHHCCCCCCC	42.58	28551015
422	Phosphorylation	MNQLLSRTPALSPQR HHHHHHCCCCCCCCC	14.99	30411139
426	Phosphorylation	LSRTPALSPQRPLTT HHCCCCCCCCCCCCC	22.54	30411139
432	Phosphorylation	LSPQRPLTTQQPQSG CCCCCCCCCCCCCCC	25.82	25403869
433	Phosphorylation	SPQRPLTTQQPQSGT CCCCCCCCCCCCCCC	32.65	25403869
438	Phosphorylation	LTTQQPQSGTLKEPD CCCCCCCCCCCCCCC	40.19	25403869
442	Ubiquitination	QPQSGTLKEPDSSKT CCCCCCCCCCCCCCC	68.02	-
449 (in isoform 2)	Phosphorylation	-	41.99	25403869
544	Phosphorylation	PHPQLNKSQSLTNAF CCCCCCHHHHHHHHH	24.75	27115346
546	Phosphorylation	PQLNKSQSLTNAFSF CCCCHHHHHHHHHCC	44.23	27115346
552	Phosphorylation	QSLTNAFSFSESSFF HHHHHHHCCCHHHHH	26.00	27115346
562	Phosphorylation	ESSFFRSSANEDEAK HHHHHCCCCCHHHHH	30.75	25403869
578	Acetylation	ETIRSLRKSFASLFS HHHHHHHHHHHHHHC	56.04	-
579	Phosphorylation	TIRSLRKSFASLFSD HHHHHHHHHHHHHCC	21.44	25403869
582	Phosphorylation	SLRKSFASLFSD--- HHHHHHHHHHCC---	28.12	25403869
585	Phosphorylation	KSFASLFSD------ HHHHHHHCC------	47.94	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
10	S	Phosphorylation	Kinase	PRKACA	P27791	GPS
10	S	Phosphorylation	Kinase	CAMK1	Q63450	Uniprot
10	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
10	S	Phosphorylation	10571231
Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles.
426	S	Phosphorylation	22673903
Phosphorylation at Ser-426 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYN2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SYN2_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYN2_RAT

Related Literatures of Post-Translational Modification

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