dbPTM

SYN1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYN1_RAT
UniProt AC	P09951
Protein Name	Synapsin-1
Gene Name	Syn1
Organism	Rattus norvegicus (Rat).
Sequence Length	704
Subcellular Localization	Cell junction, synapse. Golgi apparatus.
Protein Description	Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release..
Protein Sequence	MNYLRRRLSDSNFMANLPNGYMTDLQRPQPPPPPPSAASPGATPGSAAASAERASTAAPVASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSGGAGRGGAAARVLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSVNSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIASVVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMTQALPRQRDASPGRGSHSQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTAAPQQSASQATPMTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQASISGPAPPKVSGASPGGQQRQGPPQKPPGPAGPIRQASQAGPGPRTGPPTTQQPRPSGPGPAGRPTKPQLAQKPSQDVPPPIIAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVKAETIRSLRKSFASLFSD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	NYLRRRLSDSNFMAN CHHHHHCCCCCHHHC	36.86	22045728
11	Phosphorylation	LRRRLSDSNFMANLP HHHHCCCCCHHHCCC	28.70	27097102
36	Phosphorylation	QPPPPPPSAASPGAT CCCCCCCCCCCCCCC	42.09	27097102
39	Phosphorylation	PPPPSAASPGATPGS CCCCCCCCCCCCCCH	24.47	27097102
43	Phosphorylation	SAASPGATPGSAAAS CCCCCCCCCCHHHHH	33.81	27097102
55	Phosphorylation	AASAERASTAAPVAS HHHHHHHHHCCCCCC	25.46	27097102
55	O-linked_Glycosylation	AASAERASTAAPVAS HHHHHHHHHCCCCCC	25.46	20657584
56	O-linked_Glycosylation	ASAERASTAAPVASP HHHHHHHHCCCCCCC	26.34	20657584
56	Phosphorylation	ASAERASTAAPVASP HHHHHHHHCCCCCCC	26.34	27097102
62	Phosphorylation	STAAPVASPAAPSPG HHCCCCCCCCCCCCC	18.46	14557263
67	Phosphorylation	VASPAAPSPGSSGGG CCCCCCCCCCCCCCC	36.85	14557263
70	Phosphorylation	PAAPSPGSSGGGGFF CCCCCCCCCCCCCHH	29.24	27097102
71	Phosphorylation	AAPSPGSSGGGGFFS CCCCCCCCCCCCHHH	47.58	30411139
78	Phosphorylation	SGGGGFFSSLSNAVK CCCCCHHHHHHHHHH	28.27	28551015
79	Phosphorylation	GGGGFFSSLSNAVKQ CCCCHHHHHHHHHHH	30.57	28551015
81	Phosphorylation	GGFFSSLSNAVKQTT CCHHHHHHHHHHHHH	25.37	28551015
87	O-linked_Glycosylation	LSNAVKQTTAAAAAT HHHHHHHHHHHHHHH	16.82	20657584
96	O-linked_Glycosylation	AAAAATFSEQVGGGS HHHHHHHHHHCCCCC	23.82	20657584
103	O-linked_Glycosylation	SEQVGGGSGGAGRGG HHHCCCCCCCCCCCC	37.01	20657584
129	Phosphorylation	PHTDWAKYFKGKKIH CCCHHHHHHCCCEEE	11.63	-
177	Phosphorylation	NGVKVVRSLKPDFVL CCEEEHHHCCCCEEE	29.18	25403869
179	Acetylation	VKVVRSLKPDFVLIR EEEHHHCCCCEEEEE	43.73	22902405
238	Ubiquitination	QMVRLHKKLGTEEFP HHHHHHHHHCCCCCC	41.21	-
238	Acetylation	QMVRLHKKLGTEEFP HHHHHHHHHCCCCCC	41.21	22902405
261	O-linked_Glycosylation	NHKEMLSSTTYPVVV CHHHHHHCCCCEEEE	22.32	20657584
299	Ubiquitination	ASVVALTKTYATAEP HHHHHHCCCCCCCCC	40.15	-
301	Phosphorylation	VVALTKTYATAEPFI HHHHCCCCCCCCCCC	11.96	20530578
311	Ubiquitination	AEPFIDAKYDVRVQK CCCCCCCCCCEEEEE	37.93	-
311	Acetylation	AEPFIDAKYDVRVQK CCCCCCCCCCEEEEE	37.93	22902405
312	Phosphorylation	EPFIDAKYDVRVQKI CCCCCCCCCEEEEEC	22.76	-
332	Phosphorylation	AYMRTSVSGNWKTNT EEEEECCCCCCCCCC	26.61	22673903
337	Phosphorylation	SVSGNWKTNTGSAML CCCCCCCCCCCHHHH	29.63	28551015
339	Phosphorylation	SGNWKTNTGSAMLEQ CCCCCCCCCHHHHHH	37.43	28551015
341	Phosphorylation	NWKTNTGSAMLEQIA CCCCCCCHHHHHHHH	14.41	25403869
390	Phosphorylation	HIIEVVGSSMPLIGD CEEEEECCCCCCCCC	16.32	25403869
391	Phosphorylation	IIEVVGSSMPLIGDH EEEEECCCCCCCCCC	20.63	25403869
425	Phosphorylation	LPRQRDASPGRGSHS CCCCCCCCCCCCCCC	31.98	30411139
428	Methylation	QRDASPGRGSHSQTP CCCCCCCCCCCCCCC	46.99	-
430	Phosphorylation	DASPGRGSHSQTPSP CCCCCCCCCCCCCCC	20.71	30411139
430	O-linked_Glycosylation	DASPGRGSHSQTPSP CCCCCCCCCCCCCCC	20.71	20657584
432	Phosphorylation	SPGRGSHSQTPSPGA CCCCCCCCCCCCCCC	37.13	30411139
434	Phosphorylation	GRGSHSQTPSPGALP CCCCCCCCCCCCCCC	28.84	30411139
436	Phosphorylation	GSHSQTPSPGALPLG CCCCCCCCCCCCCCC	39.08	30411139
446	Phosphorylation	ALPLGRQTSQQPAGP CCCCCCCCCCCCCCC	27.43	27097102
447	Phosphorylation	LPLGRQTSQQPAGPP CCCCCCCCCCCCCCC	20.62	27097102
474	Methylation	QPGPGPQRQGPPLQQ CCCCCCCCCCCCHHC	46.70	-
500	Phosphorylation	GLGPPAGSPLPQRLP CCCCCCCCCCCCCCC	25.93	28432305
508	Phosphorylation	PLPQRLPSPTAAPQQ CCCCCCCCCCCCCCC	39.20	30411139
510	Phosphorylation	PQRLPSPTAAPQQSA CCCCCCCCCCCCCCC	39.53	27097102
516	Phosphorylation	PTAAPQQSASQATPM CCCCCCCCCHHCCCC	25.33	28432305
516	O-linked_Glycosylation	PTAAPQQSASQATPM CCCCCCCCCHHCCCC	25.33	20657584
524	O-linked_Glycosylation	ASQATPMTQGQGRQS CHHCCCCCCCCCCCC	30.65	20657584
532	Methylation	QGQGRQSRPVAGGPG CCCCCCCCCCCCCCC	22.75	-
545	Methylation	PGAPPAARPPASPSP CCCCCCCCCCCCCCC	39.58	-
549	Phosphorylation	PAARPPASPSPQRQA CCCCCCCCCCCCCCC	31.52	14557263
551	Phosphorylation	ARPPASPSPQRQAGP CCCCCCCCCCCCCCC	31.04	25403869
554	Methylation	PASPSPQRQAGPPQA CCCCCCCCCCCCCCC	31.53	-
562	Phosphorylation	QAGPPQATRQASISG CCCCCCCCCCCCCCC	20.33	-
562	O-linked_Glycosylation	QAGPPQATRQASISG CCCCCCCCCCCCCCC	20.33	20657584
566	Phosphorylation	PQATRQASISGPAPP CCCCCCCCCCCCCCC	14.67	25403869
568	Phosphorylation	ATRQASISGPAPPKV CCCCCCCCCCCCCCC	35.91	27097102
576	O-linked_Glycosylation	GPAPPKVSGASPGGQ CCCCCCCCCCCCCCC	34.47	20657584
579	Phosphorylation	PPKVSGASPGGQQRQ CCCCCCCCCCCCCCC	27.83	30411139
591	Ubiquitination	QRQGPPQKPPGPAGP CCCCCCCCCCCCCCC	59.98	-
603	Phosphorylation	AGPIRQASQAGPGPR CCCCCCHHHCCCCCC	16.54	20035839
620	Methylation	PPTTQQPRPSGPGPA CCCCCCCCCCCCCCC	33.41	-
631	Phosphorylation	PGPAGRPTKPQLAQK CCCCCCCCCCCCCCC	54.73	27097102
631 (in isoform 2)	Phosphorylation	-	54.73	27097102
640	Phosphorylation	PQLAQKPSQDVPPPI CCCCCCCCCCCCCCE	46.15	27097102
640 (in isoform 2)	Phosphorylation	-	46.15	27097102
662	Phosphorylation	PHPQLNKSQSLTNAF CCCCCCHHHCCHHCC	24.75	27097102
662 (in isoform 2)	Phosphorylation	-	24.75	27115346
664	Phosphorylation	PQLNKSQSLTNAFNL CCCCHHHCCHHCCCC	44.23	30411139
666	Phosphorylation	LNKSQSLTNAFNLPE CCHHHCCHHCCCCCC	29.73	28551015
678	Methylation	LPEPAPPRPSLSQDE CCCCCCCCCCCCHHH	32.17	-
678	Asymmetric dimethylarginine	LPEPAPPRPSLSQDE CCCCCCCCCCCCHHH	32.17	-
680	Phosphorylation	EPAPPRPSLSQDEVK CCCCCCCCCCHHHHH	41.76	30411139
682	Phosphorylation	APPRPSLSQDEVKAE CCCCCCCCHHHHHHH	39.67	30240740
696	Acetylation	ETIRSLRKSFASLFS HHHHHHHHHHHHHHC	56.04	22902405
697	Phosphorylation	TIRSLRKSFASLFSD HHHHHHHHHHHHHCC	21.44	25403869
700	Phosphorylation	SLRKSFASLFSD--- HHHHHHHHHHCC---	28.12	25403869
703	Phosphorylation	KSFASLFSD------ HHHHHHHCC------	47.94	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
9	S	Phosphorylation	Kinase	PRKACA	P27791	GPS
9	S	Phosphorylation	Kinase	CAMK1A	Q63450	PSP
9	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
9	S	Phosphorylation	Kinase	CAM-KI_GROUP	-	PhosphoELM
9	S	Phosphorylation	Kinase	PKA	-	Uniprot
9	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
9	S	Phosphorylation	Kinase	CAMK1-FAMILY	-	GPS
9	S	Phosphorylation	Kinase	PAK1	P35465	PSP
62	S	Phosphorylation	Kinase	MAPK3	P21708	GPS
62	S	Phosphorylation	Kinase	ERK1	P27361	PSP
62	S	Phosphorylation	Kinase	ERK2	P28482	PSP
62	S	Phosphorylation	Kinase	MAPK1	P63086	GPS
67	S	Phosphorylation	Kinase	ERK1	P27361	PSP
67	S	Phosphorylation	Kinase	MAPK3	P21708	GPS
67	S	Phosphorylation	Kinase	MAPK1	P63086	GPS
67	S	Phosphorylation	Kinase	ERK2	P28482	PSP
301	Y	Phosphorylation	Kinase	SRC	Q9WUD9	PSP
337	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
337	T	Phosphorylation	Kinase	LRRK2	Q5S006	PSP
339	T	Phosphorylation	Kinase	LRRK2	Q5S006	PSP
339	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
549	S	Phosphorylation	Kinase	ERK1	P27361	PSP
549	S	Phosphorylation	Kinase	MAPK3	P21708	GPS
549	S	Phosphorylation	Kinase	MAPK1	P63086	GPS
551	S	Phosphorylation	Kinase	CDK5	Q03114	PSP
551	S	Phosphorylation	Kinase	PDPK1	O55173	Uniprot
566	S	Phosphorylation	Kinase	CAM-KII_GROUP	-	PhosphoELM
566	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
566	S	Phosphorylation	Kinase	CAMK2	-	Uniprot
566	S	Phosphorylation	Kinase	CAMK2B	P08413	GPS
566	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
603	S	Phosphorylation	Kinase	CAMK2B	P08413	GPS
603	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
603	S	Phosphorylation	Kinase	CAMK2	-	Uniprot
603	S	Phosphorylation	Kinase	CAM-KII_GROUP	-	PhosphoELM
603	S	Phosphorylation	Kinase	CAMK2D	P15791	GPS
603	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
603	S	Phosphorylation	Kinase	PAK1	P35465	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
9	S	Phosphorylation		10571231
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYN1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SYN1_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYN1_RAT

Related Literatures of Post-Translational Modification

O-linked Glycosylation
Reference	PubMed
"Mapping sites of O-GlcNAc modification using affinity tags for serineand threonine post-translational modifications."; Wells L., Vosseller K., Cole R.N., Cronshaw J.M., Matunis M.J.,Hart G.W.; Mol. Cell. Proteomics 1:791-804(2002). Cited for: GLYCOSYLATION AT SER-55; THR-87; SER-96; SER-103; SER-261; SER-430 ANDSER-516.	12438562 [Abstract]
"Glycosylation sites flank phosphorylation sites on synapsin I: O-linked N-acetylglucosamine residues are localized within domainsmediating synapsin I interactions."; Cole R.N., Hart G.W.; J. Neurochem. 73:418-428(1999). Cited for: GLYCOSYLATION AT SER-55; THR-56; THR-87; SER-516; THR-524; THR-562 ANDSER-576.	10386995 [Abstract]

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