SYKC_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYKC_ARATH
• UniProt AC: Q9ZPI1
• Protein Name: Lysine--tRNA ligase, cytoplasmic {ECO:0000305}
• Gene Name: At3g11710
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 626
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (By similarity). Promotes aminoacylation of non-cognate tRNAs and translational recoding of lysine at nonsense codons. [PubMed: 17425721]
• Protein Sequence: MEGAADQTTKALSELAMDSSTTLNAAESSAGDGAGPRSKNALKKEQKMKQKEEEKRRKDEEKAEKAKQAPKASSQKAVAADDEEMDATQYYENRLKYLAAEKAKGENPYPHKFAVSMSIPKYIETYGSLNNGDHVENAEESLAGRIMSKRSSSSKLFFYDLHGDDFKVQVMADASKSGLDEAEFLKLHSNAKRGDIVGVIGFPGKTKRGELSIFPRSFILLSHCLHMMPRKADNVNAKKPEIWVPGQTRNPEAYVLKDQESRYRQRHLDMILNVEVRQIFRTRAKIISYVRRFLDNKNFLEVETPMMNMIAGGAAARPFVTHHNDLDMRLYMRIAPELYLKQLIVGGLERVYEIGKQFRNEGIDLTHNPEFTTCEFYMAFADYNDLMEMTEVMLSGMVKELTGGYKIKYNANGYDKDPIEIDFTPPFRRIEMIGELEKVAKLNIPKDLASEEANKYLIDACARFDVKCPPPQTTARLLDKLVGEFLEPTCVNPTFIINQPEIMSPLAKWHRSKSGLTERFELFINKHELCNAYTELNDPVVQRQRFADQLKDRQSGDDEAMALDETFCNALEYGLAPTGGWGLGIDRLSMLLTDSLNIKEVLFFPAMRPPQEESAAAQAPLTEEKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGAADQT -------CCCHHHHH		22223895
1	Sulfoxidation	-------MEGAADQT -------CCCHHHHH		25693801
10	Acetylation	GAADQTTKALSELAM CHHHHHHHHHHHHHC		21311031
85	Sulfoxidation	VAADDEEMDATQYYE HHCCCCCCCHHHHHH		23289948
171	Sulfoxidation	DDFKVQVMADASKSG CCEEEEEECCHHHCC		25693801
514	Phosphorylation	AKWHRSKSGLTERFE HHHHHCCCCCCHHHH		25561503
534	Phosphorylation	HELCNAYTELNDPVV HHHHHHHHHCCCHHH		19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYKC_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYKC_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYKC_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of SYKC_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.