SYIC_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYIC_SCHPO
• UniProt AC: O13651
• Protein Name: Isoleucine--tRNA ligase, cytoplasmic
• Gene Name: irs1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1064
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MSFNVPKEEEKIVEFWREIDAFHTQLKLSQGRPTYTFFDGPPFATGRPHHGHLLASTIKDSVTRYACLKGYHVERRFGWDTHGLPVEHEIDKKLGITGSDDVMAMGIDKYNAECRKIVMTYASEWRATVERLGRWIDFDNDYKTLYPSFMESVWWVFKELHTKGKVYRGYRVMPYSTACTTPLSNFEAQQNYKEVPDPAIVVAFQSISDPEVSFLAWTTTPWTLPSNLALAVHPDLQYIKILDKDSNKKYILMESCLGILYKNPKKANFEILERFQGKALDGQKYEPLFPYFKSTFGERAFKLYSADYVEEGSGTGIVHQAPAFGEADYDAAWAAGIIDADHQPPCPVDEQGLLTSEITDFAGQYVKDADKEIIRSLKASGHLVKHSQIFHSYPFCWRSDTPLIYRAVPSWFVRVKEITNEMVENVMSTHWVPQNIRDKRFANWLKNARDWNISRNRYWGTPIPLWVSDDYEEVVCIGSIKELEELSGVSNITDIHRDSIDHITIPSKKGKGTLHRVSEVFDCWFESGSMPYASRHYPFERIEEFKHGFPADFISEGVDQTRGWFYTLTVLGTLLFDKAPYKNVIVSGLVMAEDGKKMSKRLKNYPEPNLIIEKYGSDALRLYLINSPVVRAEILKFKEDGVREVVTRVLIPWWNSYKFFEAQAALYKKVTGKDFVFDDAATLSSNVMDRWILARCQSLIGFVDEEMKQYRLYTVVPQLLGLIEEMTNWYIRFNRRRLKGEDGEIETINALNVLFEVLFTLVRIMGPFTPFITENIYQHLRNYMPIDKNEISLRSVHFLPFPTYKSELDDETVLRRVKRMQTIIELARYVREQNNISLKTPLKTLIVILTNEEYLEDAKLLERYIAEELNVREVVFTSNEEKYGVVYSVQADWPVLGKKLRKDMARVKKALPNVTSEEVKEFQKNKKMVLDGIELVEGDLQIIRSVEVKNEFLKSNTDGICIVLLDIEIDAQLQAEGLAREVINRVQRLRKKSNLQVTDDVRMTYKIKNDTIGLESAVDSNEALFSKVLRRPIEKETGADESNIIASEEQDVQGATFLLSLLRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
399	Phosphorylation	SYPFCWRSDTPLIYR CCCCCCCCCCCCHHC	22.72	25720772
401	Phosphorylation	PFCWRSDTPLIYRAV CCCCCCCCCCHHCCC	22.65	25720772
685	Phosphorylation	DDAATLSSNVMDRWI CCHHHHCCCHHHHHH	36.23	25720772
795	Phosphorylation	KNEISLRSVHFLPFP CCCCEECEEEECCCC	25.82	25720772
806	Phosphorylation	LPFPTYKSELDDETV CCCCCCCCCCCHHHH	32.74	25720772
945	Phosphorylation	GDLQIIRSVEVKNEF CCEEEEEEEEEHHHH	16.54	25720772
993	Phosphorylation	VQRLRKKSNLQVTDD HHHHHHHCCCCCCCC	45.89	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYIC_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYIC_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYIC_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of SYIC_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.