SYDE2_HUMAN - dbPTM
SYDE2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYDE2_HUMAN
UniProt AC Q5VT97
Protein Name Rho GTPase-activating protein SYDE2
Gene Name SYDE2
Organism Homo sapiens (Human).
Sequence Length 1194
Subcellular Localization
Protein Description GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state..
Protein Sequence MHDLPPDSGARRGGRGLADHSFPAGARAPGQPPSRGAAYRRACPRDGERGGGGRPRQQVSPPRSPQREPRGGQLRTPRMRPSCSRSLESLRVGAKPPPFQRWPSDSWIRCGAHRDWDEPPPRGGRMDGWSGDRARAAAPTGLQPPGCKDHGCSSGSPFRDPAGSSVIRSGKGDRQEGPSFLRPPAVTVKKLQKWMYKGRLLSLGMKGRARGTAPKVTGTQAASPNVGALKVRENRVLSVPPDQRITLTDLFENAYGSSMKGRELEELKDNIEFRGHKPLNSITVSKKRNWLYQSTLRPLNLEEENKKCQDRSHLSISPVSLPKHQLSQSFLKSSKEYCTYVVCNATNSSLSKNCALDFNEENDADDEGEIWYNPIPEDDDLGISSALSFGEADSAVLKLPAVNLSMLSGSDLMKAERHTEDSLCSSEHAGDIQTTRSNGMNPIHPAHSTEFVQQYKQKLGHKTQEGIMVEDSPMLKSPFAGSGILAATNSTELGIMEPSSPNPSPVKKGSSINWSLPDKIKSPRTVRKLSMKMKKLPEFSRKLSVKGTLNYINSPDNTPSLSKYNCREVHHTDILPSGNTTTAAKRNVISRYHLDTSVSSQQSYQKKNSMSSKYSCKGGYLSDGDSPELTTKASKHGSENKFGKGKEIISNSCSKNEIDIDAFRHYSFSDQPKCSQYISGLMSVHFYGAEDLKPPRIDSKDVFCAIQVDSVNKARTALLTCRTTFLDMDHTFNIEIENAQHLKLVVFSWEPTPRKNRVCCHGTVVLPTLFRVTKTHQLAVKLEPRGLIYVKVTLMEQWENSLHGLDINQEPIIFGVDIQKVVEKENIGLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYPDINVITGVLKDYLRELPSPLITKQLYEAVLDAMAKSPLKMSSNGCENDPGDSKYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVLLSQRQEPSTHNNRVFTDSEELASALDFKKHIEVLHYLLQLWPVQRLTVKKSTDNLFPEQKSSLNYLRQKKERPHMLNLSGTDSSGVLRPRQNRLDSPLSNRYAGDWSSCGENYFLNTKENLNDVDYDDVPSEDRKIGENYSKMDGPEVMIEQPIPMSKECTFQTYLTMQTVESTVDRKNNLKDLQESIDTLIGNLERELNKNKLNMSF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12MethylationPPDSGARRGGRGLAD
CCCCCCCCCCCCCCC		51.92115918061
15MethylationSGARRGGRGLADHSF
CCCCCCCCCCCCCCC		39.5197770689
35MethylationAPGQPPSRGAAYRRA
CCCCCCCCCCHHHCC		44.54115918065
60PhosphorylationGRPRQQVSPPRSPQR
CCCCCCCCCCCCCCC		25.5024670416
64PhosphorylationQQVSPPRSPQREPRG
CCCCCCCCCCCCCCC		31.0324670416
82O-linked_GlycosylationRTPRMRPSCSRSLES
CCCCCCCCCCCCHHH		17.8530379171
86PhosphorylationMRPSCSRSLESLRVG
CCCCCCCCHHHHCCC		21.8624719451
104PhosphorylationPPFQRWPSDSWIRCG
CCCCCCCCCCCEECC		37.0022617229
106PhosphorylationFQRWPSDSWIRCGAH
CCCCCCCCCEECCCC		28.8322617229
156PhosphorylationDHGCSSGSPFRDPAG
CCCCCCCCCCCCCCC		23.8628555341
169PhosphorylationAGSSVIRSGKGDRQE
CCCCEEECCCCCCCC		33.4623403867
187PhosphorylationFLRPPAVTVKKLQKW
CCCCCCCCHHHHHHH		28.81-
196PhosphorylationKKLQKWMYKGRLLSL
HHHHHHHHHCCCHHH		14.8023917254
212PhosphorylationMKGRARGTAPKVTGT
CCCCCCCCCCCCCCC		33.9427174698
217PhosphorylationRGTAPKVTGTQAASP
CCCCCCCCCCCCCCC		40.4127174698
219PhosphorylationTAPKVTGTQAASPNV
CCCCCCCCCCCCCCC		12.9827174698
223PhosphorylationVTGTQAASPNVGALK
CCCCCCCCCCCCCEE		21.7425159151
230UbiquitinationSPNVGALKVRENRVL
CCCCCCEEEECCCEE		38.4229967540
246PhosphorylationVPPDQRITLTDLFEN
CCCCCCEEHHHHHHH		26.29-
260UbiquitinationNAYGSSMKGRELEEL
HHHCCCCCCHHHHHH		57.68-
268UbiquitinationGRELEELKDNIEFRG
CHHHHHHHHHEEECC		52.5929967540
277UbiquitinationNIEFRGHKPLNSITV
HEEECCCCCCCCEEE		54.7629967540
292PhosphorylationSKKRNWLYQSTLRPL
CCCCCEEEHHCCCCC		7.64-
312PhosphorylationNKKCQDRSHLSISPV
HHHCCCCCCCCCCCC		36.7523186163
315PhosphorylationCQDRSHLSISPVSLP
CCCCCCCCCCCCCCC		18.6523312004
317PhosphorylationDRSHLSISPVSLPKH
CCCCCCCCCCCCCHH		18.8425849741
320PhosphorylationHLSISPVSLPKHQLS
CCCCCCCCCCHHHHC		42.1929978859
327PhosphorylationSLPKHQLSQSFLKSS
CCCHHHHCHHHHHHC		19.7421406692
329PhosphorylationPKHQLSQSFLKSSKE
CHHHHCHHHHHHCCC		29.2121406692
332UbiquitinationQLSQSFLKSSKEYCT
HHCHHHHHHCCCCEE		51.1529967540
332MethylationQLSQSFLKSSKEYCT
HHCHHHHHHCCCCEE		51.15115980281
333PhosphorylationLSQSFLKSSKEYCTY
HCHHHHHHCCCCEEE		49.1121406692
334PhosphorylationSQSFLKSSKEYCTYV
CHHHHHHCCCCEEEE		28.1121406692
335MethylationQSFLKSSKEYCTYVV
HHHHHHCCCCEEEEE		60.85115980285
405PhosphorylationKLPAVNLSMLSGSDL
CCCCCCHHHCCCHHH		16.6921406692
408PhosphorylationAVNLSMLSGSDLMKA
CCCHHHCCCHHHHHH		27.8421406692
410PhosphorylationNLSMLSGSDLMKAER
CHHHCCCHHHHHHHH		24.9721406692
434PhosphorylationEHAGDIQTTRSNGMN
CCCCCCCCCCCCCCC		25.22-
435PhosphorylationHAGDIQTTRSNGMNP
CCCCCCCCCCCCCCC		18.74-
477PhosphorylationEDSPMLKSPFAGSGI
CCCCCCCCCCCCCCE		22.6827307780
482PhosphorylationLKSPFAGSGILAATN
CCCCCCCCCEEEECC		21.1627307780
488PhosphorylationGSGILAATNSTELGI
CCCEEEECCCCCCCC		24.8927307780
490PhosphorylationGILAATNSTELGIME
CEEEECCCCCCCCCC		20.9227307780
491PhosphorylationILAATNSTELGIMEP
EEEECCCCCCCCCCC		36.9827307780
499PhosphorylationELGIMEPSSPNPSPV
CCCCCCCCCCCCCCC		45.1627307780
500PhosphorylationLGIMEPSSPNPSPVK
CCCCCCCCCCCCCCC		39.1427307780
504PhosphorylationEPSSPNPSPVKKGSS
CCCCCCCCCCCCCCC		49.3027307780
510PhosphorylationPSPVKKGSSINWSLP
CCCCCCCCCCCCCCC		36.60-
515PhosphorylationKGSSINWSLPDKIKS
CCCCCCCCCCCCCCC		26.0723312004
522PhosphorylationSLPDKIKSPRTVRKL
CCCCCCCCHHHHHHH		24.0825849741
525O-linked_GlycosylationDKIKSPRTVRKLSMK
CCCCCHHHHHHHHHH		28.2230379171
551PhosphorylationSVKGTLNYINSPDNT
CCCCCHHCCCCCCCC		12.4627642862
554PhosphorylationGTLNYINSPDNTPSL
CCHHCCCCCCCCCCH		24.8725159151
564PhosphorylationNTPSLSKYNCREVHH
CCCCHHHCCCCCCCC		19.0027251275
572PhosphorylationNCREVHHTDILPSGN
CCCCCCCCCCCCCCC		15.1727251275
577PhosphorylationHHTDILPSGNTTTAA
CCCCCCCCCCCHHHH		41.0327251275
580PhosphorylationDILPSGNTTTAAKRN
CCCCCCCCHHHHHHC		29.1127251275
581PhosphorylationILPSGNTTTAAKRNV
CCCCCCCHHHHHHCC		20.5927251275
582PhosphorylationLPSGNTTTAAKRNVI
CCCCCCHHHHHHCCE		23.6827251275
597PhosphorylationSRYHLDTSVSSQQSY
EEEECCCCCCCCHHH		21.48-
599PhosphorylationYHLDTSVSSQQSYQK
EECCCCCCCCHHHHH		23.38-
604PhosphorylationSVSSQQSYQKKNSMS
CCCCCHHHHHHCCCC		21.7329759185
620PhosphorylationKYSCKGGYLSDGDSP
CCEECCCCCCCCCCH		16.2330266825
622PhosphorylationSCKGGYLSDGDSPEL
EECCCCCCCCCCHHH		30.9419664994
626PhosphorylationGYLSDGDSPELTTKA
CCCCCCCCHHHCHHH		26.2930266825
630PhosphorylationDGDSPELTTKASKHG
CCCCHHHCHHHHHCC		25.2923927012
631PhosphorylationGDSPELTTKASKHGS
CCCHHHCHHHHHCCC		36.9223927012
655UbiquitinationIISNSCSKNEIDIDA
HCCCCCCCCCCCCHH		64.0329967540
906PhosphorylationELPSPLITKQLYEAV
HCCCCHHHHHHHHHH		22.03-
910PhosphorylationPLITKQLYEAVLDAM
CHHHHHHHHHHHHHH		10.19-
966PhosphorylationDHLKLVASYHEVNKM
HHHHHHHHHHHHHHC		21.3926074081
967PhosphorylationHLKLVASYHEVNKMT
HHHHHHHHHHHHHCH		7.7126074081
974PhosphorylationYHEVNKMTCQNLAVC
HHHHHHCHHHCHHHH		16.73-
988PhosphorylationCFGPVLLSQRQEPST
HHHHHHHHCCCCCCC		21.1124719451
994PhosphorylationLSQRQEPSTHNNRVF
HHCCCCCCCCCCCCC		41.3621406692
995PhosphorylationSQRQEPSTHNNRVFT
HCCCCCCCCCCCCCC		39.0621406692
1037PhosphorylationQRLTVKKSTDNLFPE
CEEEECCCCCCCCHH		34.9627251275
1038PhosphorylationRLTVKKSTDNLFPEQ
EEEECCCCCCCCHHH		37.4727251275
1082PhosphorylationPRQNRLDSPLSNRYA
CCCCCCCCCCCCCCC		32.1225849741
1085PhosphorylationNRLDSPLSNRYAGDW
CCCCCCCCCCCCCCC		23.7325056879
1112PhosphorylationENLNDVDYDDVPSED
CCCCCCCCCCCCHHH		17.5627642862
1117PhosphorylationVDYDDVPSEDRKIGE
CCCCCCCHHHHCCCC		52.5629083192
1126PhosphorylationDRKIGENYSKMDGPE
HHCCCCCCCCCCCCE		12.83-
1127PhosphorylationRKIGENYSKMDGPEV
HCCCCCCCCCCCCEE		32.84-
1147PhosphorylationIPMSKECTFQTYLTM
CCCCCCCEEEEEEEH		21.6230576142
1160PhosphorylationTMQTVESTVDRKNNL
EHHHHHHHCCCCCCH		16.9630576142
1193PhosphorylationNKNKLNMSF------
HHHCCCCCC------		27.0822617229
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYDE2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYDE2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYDE2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SYDE2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYDE2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-622, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-622, AND MASSSPECTROMETRY.

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