dbPTM

SYDC_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYDC_RAT
UniProt AC	P15178
Protein Name	Aspartate--tRNA ligase, cytoplasmic
Gene Name	Dars
Organism	Rattus norvegicus (Rat).
Sequence Length	501
Subcellular Localization	Cytoplasm.
Protein Description	Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA..
Protein Sequence	MPSANASRKGQEKPREIVDAAEDYAKERYGVSSMIQSQEKPDRVLVRVKDLTVQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIIDVEGIVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAIRPEVEGEEDGRATVNQDTRLDNRIIDLRTSTSQAIFHLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKSNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMDDEEDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Phosphorylation	LVRVKDLTVQKADEV EEEEEECEEEECCEE	30.90	-
74	Acetylation	HTSRAKGKQCFLVLR ECHHCCCCEEEEEEE	43.09	-
103	Acetylation	HASKQMVKFAANINK HHHHHHHHHHHCCCH	24.76	22902405
249	Phosphorylation	SNAYLAQSPQLYKQM CCCEECCCHHHHHHH	14.70	27097102
253	Phosphorylation	LAQSPQLYKQMCICA ECCCHHHHHHHHHHC	8.23	23984901
374	Acetylation	DLSTPNEKLLGRLVK CCCCCCHHHHHHHHH	56.50	-
451	Acetylation	HHGIDLEKIKAYIDS HCCCCHHHHHHHHHH	57.72	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SYDC_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SYDC_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYDC_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SYDC_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYDC_RAT

Related Literatures of Post-Translational Modification